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Biomedical subjects

G Barclay

Publications and source records attributed to G Barclay.

14 recordsLinked to original sources

Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial.

OBJECTIVE: To study the efficacy and tolerability of borage oil, which contains a high concentration of gamma linolenic acid, in children and adults with atopic eczema. DESIGN: Single centre, randomised, double blind, placebo controlled, parallel group trial. SETTING: Acute district general hospital in Nuneaton, England. PARTICIPANTS: 151 patients, of whom 11 failed to return for assessment, leaving an evaluable population of 140 (including 69 children). INTERVENTION: Adults received four capsules of borage oil twice daily (920 mg gamma linolenic acid), and children received two capsules twice daily, for 12 weeks. MAIN OUTCOME MEASURES: Change in total sign score at 12 weeks measured with the six area, six sign, atopic dermatitis (SASSAD) score (primary endpoint); symptom scores, assessed on visual analogue scales; topical corticosteroid requirement, assessed on a five point scale; global assessment of response by participants; adverse events and tolerability. RESULTS: The mean SASSAD score fell from 30 to 27 in the borage oil group and from 28 to 23 in the placebo group. The difference between the mean improvements in the two groups was 1.4 (95% confidence interval -2.2 to 5.0) points in favour of placebo (P = 0.45). No significant differences occurred between treatment groups in the other assessments. Subset analysis of adults and children did not indicate any difference in response. The treatments were well tolerated. CONCLUSION: Gamma linolenic acid is not beneficial in atopic dermatitis.

Adult↗

Hairy polyp of the oropharynx in a newborn: a case report.

An unusual case of an oropharyngeal mass in a neonate causing intermittent airway obstruction during the first 24 hours following delivery is presented. This mass was confirmed to be a hairy polyp. We discuss the incidence, histology and peri-operative management of this unusual lesion.

Airway Obstruction↗

Azathioprine in severe adult atopic dermatitis: a double-blind, placebo-controlled, crossover trial.

BACKGROUND: There is a limited range of treatments for severe atopic dermatitis (AD). Azathioprine has often been used but there has been no randomized controlled trial of this drug to confirm its efficacy in AD. OBJECTIVES: To establish or refute the efficacy of azathioprine in severe AD. To investigate the safety and tolerability of azathioprine in this patient population. METHODS: We performed a double-blind, randomized, placebo-controlled, crossover trial of azathioprine in adult patients with severe AD. Each treatment period was of 3 months' duration. Treatments were azathioprine 2.5 mg kg(-1) day(-1) and matched placebo. Disease activity was monitored using the SASSAD sign score. In addition, severity of pruritus, sleep disturbance and disruption of work/daytime activity were monitored using visual analogue scales. Adverse events were recorded and haematological and biochemical monitoring was performed. RESULTS: Thirty-seven subjects were enrolled, mean age 38 years (range 17-73). Sixteen were withdrawn, 12 during azathioprine treatment and four during placebo treatment. The SASSAD score fell by 26% during treatment with azathioprine vs. 3% on placebo (P < 0.01). Pruritus, sleep disturbance and disruption of work/daytime activity all improved significantly on active treatment but not on placebo. The difference in mean improvement between azathioprine and placebo was significant for disruption of work/daytime activity (P < 0.02) but not for pruritus or sleep disturbance. Gastrointestinal disturbances were reported by 14 patients during azathioprine treatment and four were withdrawn as a result of severe nausea and vomiting. Leukopenia was observed in two patients and deranged liver enzymes in eight during treatment with azathioprine. CONCLUSIONS: Azathioprine is an effective and useful drug in severe AD although it is not always well-tolerated. Monitoring of the full blood count and liver enzymes is advisable during treatment.

Adolescent↗

Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy.

Cyclosporin (CyA) has been shown to be highly effective and well tolerated in the short-term treatment of severe childhood atopic dermatitis; however, there is limited experience in its longer-term use. The aim of this study was to compare multiple short courses of CyA with continuous therapy for 1 year, with respect to efficacy, safety, tolerability and quality of life. Children aged 2-16 years, with a diagnosis of severe atopic dermatitis refractory to topical steroid therapy, were randomly assigned to receive short course therapy (multiple courses of 12 weeks) or continuous therapy. The starting dose and maximum dose for all patients was 5 mg/kg per day. Disease activity was monitored using the Six Area Six Sign Atopic Dermatitis score and the 'Rule of Nines' area score. Pruritus, sleep disturbance and irritability were measured using visual analogue scales, and topical therapy was monitored. Safety measurements included monitoring of serum creatinine, blood pressure and adverse events. Forty patients were included in the efficacy analysis, 21 of whom were randomized to the short course group (of whom six were withdrawn) and 19 to the continuous group (of whom five were withdrawn). Significant improvements were seen in all efficacy parameters at every time-point. There were no significant differences between groups, although the improvement was more consistent in the continuous arm. In the short course arm, 7 out of 21 patients could be managed by at least two short courses. The remaining 14 patients includes 12 who could not be controlled by at least two short courses, one patient who failed to return after week 12 and another patient who was withdrawn at week 4 due to an adverse event. Quality of life improved for both the children and their families. Tolerability was considered good or very good in at least 80% of the patients at week 12 and at the end of the study. No clinically significant change was seen in mean serum creatinine and no change was seen in mean blood pressure in either group. CyA is effective in controlling severe atopic dermatitis in children over a 1-year period and is well tolerated. More consistent control is achieved with continuous treatment; however, short course therapy was adequate for some patients, indicating that treatment should be tailored to the individual patient's needs. Short course treatment may produce prolonged remission in some cases and reduce the cumulative exposure to the drug.

Adolescent↗

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Journal Article↗

Tobacco control: a brief review of its history and prospects for the future.

Smoking prevalence among American adults is at its lowest point in the last 30 years, and there is unprecedented popular support for tobacco control measures. The financial resources to carry on the battle for tobacco control are still heavily stacked in favor of the industry, which by current estimates is worth $45 billion, including $6 billion spent each year on advertising and promotion alone. Nonetheless, industry executives must realize that, even if they can win individual battles, they are losing the war. This article has discussed key events in the history of tobacco control, as well as some of the most innovative strategies currently being used for tobacco control. Although it is important that tobacco control efforts be disseminated widely and through novel channels, the challenge facing public health advocates in the next several decades will be to anticipate the industry's response to key initiatives, as well as to launch organized and strategic counterattacks against efforts to dissuade acceptance of such initiatives. The history of tobacco control demonstrates that public health advocacy resources should be strategically focused in precisely the areas in which the industry feels most vulnerable (e.g., nicotine addiction, regulation of nicotine, environmental tobacco smoke), rather than in areas in which the industry maintains a vocal presence for the purposes of public relations (e.g., youth access). Through its lobbying efforts and financial clout, the tobacco industry has played a key role in the development of public health policy. Although it is no secret that the tobacco industry regularly makes campaign contributions to both Republicans and Democrats, the impact of these donations on public policy making have only recently begun to be quantified and documented. Moore et al found that the more tobacco money a politician received, the less likely he or she was to support tobacco control legislation. Similar distortional effects of tobacco money have been demonstrated at the state level. The political expenditure of 12 tobacco firms increased 10-fold in California after the implementation of Proposition 99 in California--from $790,050 in the 1985-1986 election, to $7,615,091 in the 1991-1992 election. In an analysis of the behavior of the California legislature between 1991 and 1992, a statistically significant relationship was found between members' receipt of tobacco money and their likelihood of opposing tobacco control measures. Tobacco control advocates as well as health professionals in general have an important role to play in holding their legislators accountable for developing public health policy that reflects the concerns of their constituencies, not of the tobacco lobby. Public health advocates should pay particular attention to the recent regulations placed on cigarettes as a key tobacco control strategy for the next several decades. For the first time in the history of the United States, a President has introduced legislation that will allow a governmental agency to regulate tobacco. The FDA has faced relentless attacks by the tobacco industry, and it will continue to be a target. Public health advocates and health care providers have a critical role to play in the FDA's efforts to bring this issue to fruition. If the public health community fails to support this initiative and create an active and forceful opposition to the industry's efforts to derail it, it is likely that the impact on tobacco control efforts will be resounding and far-reaching.

Adult↗

Functional control of gastrin releasing peptide (GRP) mRNA in rat stomach.

The gastric factors controlling abundance of mRNA encoding the important neuropeptide, gastrin releasing peptide (GRP) in rat stomach, were examined by Northern and slot blot analysis. Withdrawal of food increased antral GRP mRNA, as did treatment of fed rats with the acid inhibitory drug, omeprazole. There was no change in GRP mRNA abundance in gastric corpus. The data indicate functionally distinct populations of GRP neurons in different regions of the stomach, and control of antral neuropeptide biosynthesis by the gastric luminal contents.

Animals↗

Effects of graded amounts of intragastric calcium on acid secretion, gastrin release, and gastric emptying in normal and duodenal ulcer subjects.

We studied effects of graded concentrations of intragastric calcium on acid secretion, residual gastric volume, and serum gastrin and calcium levels. Intragastric titration was performed with solutions of isotonic mannitol or mannitol plus 2.5, 6, 16, 39, and 97 mM CaCl(2) in 10 normal and eight duodenal ulcer subjects. Acid secretion was significantly increased above control values by the two highest CaCl2 concentrations in normal subjects and by the three highest CaCl2 concentrations in ulcer subjects. Highest observed acid output to any concentration of CaCl2 was 55% of peak acid output to pentagastrin in normal subjects and 75% in ulcer subjects. Intragastric calcium also released gastrin; correlation between acid secretion and circulating gastrin was weak (r = 0.43, P less than 0.05). Serum calcium was slightly increased but did not correlate with acid secretion. Residual intragastric volume after both control and CaCl2 solutions was much less in ulcer than in normal subjects; calcium did not alter residual volumes.

Adult↗

Phospholipid dependence of calcium ion effects on electrophoretic mobilities of liposomes.

Electrophoretic light scattering (ELS) and depolarization of fluorescence have been used to determine the effect of membrane fluidity on the binding of Ca2+ to liposomes. ELS was used to measure the electrophoretic mobilities of the liposomes. Fluorescence depolarization was used to determine membrane fluidity. Zero to 30 mol% phosphatidylserine (PS) was incorporated into liposomes containing, as bulk phospholipids, one of the following: dimyristoyl-phosphatidylcholine (DMPC), dipalmitoylphosphatidylcholine (DPPC), egg phosphatidylcholine (PC), or hydrogenated egg phosphatidylcholine (H egg PC). The binding of Ca2+ to the liposomes appears to be influenced by membrane fluidity. Liposomes containing bulk phospholipids whose phase transition temperature is higher than the experimental temperature exhibit enhanced binding of CA2+.

Calcium↗

Endoscopic therapy of pancreatitis in the pediatric population.

Six children with chronic relapsing pancreatitis or acute post-traumatic pancreatic pseudocyst underwent therapeutic pancreatography at the time of ERCP. Procedures included pancreaticobiliary sphincterotomy, pancreatic duct stone removal, and endoprosthesis placement. Four of five patients with chronic pancreatitis had significant symptomatic improvement, whereas the patient with pseudocyst had rapid resolution of symptoms and cyst. Complications were limited to mild pancreatitis in a subset of patients. With the capability of obviating or delaying the need for palliative pancreatic surgery, therapeutic pancreatography deserves additional evaluation in the pediatric patient.

Adolescent↗