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Biomedical subjects

G Bartsch

Publications and source records attributed to G Bartsch.

At least 37 records · Page 2Linked to original sources
PubMed1977

Stereology, a new quantitative morphological approach to study prostatic function and disease.

Although a considerable amount of quantitative biochemical data of the prostatic gland is available the current morphological information is restricted up to now to descriptive findings. Stereology is the application of mathematical axioms and allows one to quantitate three-dimensional structures from the measurement of two-dimensional cross sections thereof. The stereological techniques provide values for volumes, surfaces and number of tissue and glandular cellular components found within the prostatic gland. Four examples are presented to illustrate how quantitative morphology can be applied to study prostatic function and disease. A stereological model, which provides information on the structure of the prostatic gland is shown for the rat prostate (ventral lobe). The model consists of morphologically defined space and membrane components of the prostatic gland and the glandular cell. The alteration, induced in the glandular cells of the ventral lobe of the rat prostate by administration of a synthetic progestine (ethinyl-norgestrienone) were studied by stereological methods. An attempt was made to quantify the morphological aspects of both, the epithelial and stromal components of the normal human prostate (3rd decade of life) and of benign prostatic hyperplasia. In comparing the stereological data of the glandular prostatic cell in the normal human prostate with that in benign prostatic hyperplasia, a diminished secretory activity of the glandular cell in benign prostatic hyperplasia is indicated. A high volume density of the fibromuscular tissue, as well as an activation of the smooth muscle cell in the fibromuscular tissue is observed in benign prostatic hyperplasia.

Adult↗
PubMed1977

[Electron microscope studies on spread of Fusarium sulphureum Schlecht. in potato tuber tissue (author's transl)].

An electron microscope study has shown that the spread of Fusarium sulphureum through potato tuber tissue occurs not only intracellular but also intercellular. The spread of hyphae effected both mechanical and enzymatical. The study of cells neighbouring hyphae shows degeneration of protoplasm. Intercellular spaces of infected tissue are filled with a dark substance. It seems that these substances are fragments of cell walls which are macerated by Fusarium enzymes.

Fusarium↗
PubMed1977

[Possibilities of the quantitative structural analysis of prostate biopsies].

Stereological methods allow the determination of volumes, surfaces or number of tissue and/or cell compartments. The quantitative data on human biopsy specimens of the prostate suggest a diminution of the secretory activity of the glandular cells, while the smooth muscle cells are activated: the relative volumes of the Golgi areas and the rough endoplasmic reticulum are increased. Stereology will be a valuable tool for objective search on hormonal dependence of the glandular as well as the smooth muscular cells. Therein, the role of the smooth muscle cells in benigh prostatic hyperplasia should be focused.

Biopsy↗
PubMed1977

Ultrastructural stereology: a new approach to the study of prostatic function.

Stereology is a method used to obtain quantitative information of structural changes at the light and electron microscopic level. The basic principles of stereology are outlined below. This paper shows how stereologic techniques can be used to obtain structural data from histologic and electron micrographs of intact tissue and cells. A morphometric model, which provides information on the structure of the prostatic gland has been developed for the rat prostate. The model consists of morphologically defined space and membrane compartments of the prostatic gland and the glandular cells. The alterations, induced in the glandular cells of the ventral lobe of rat prostate by the administration of a synthetic progestin (ethinyl-norgestrienone), were studied by electron microscopy. The results presented are relative to a cubic centimeter of prostatic tissue, a cubic centimeter of acinar parenchyma, and glandular cell cytoplasm. An attempt to relate stereologic and biochemical data is shown.

Animals↗
PubMed1976

[Effect of long-term treatment with synthetic oestrogens on plasma lipids and arterial vessels in male rabbits (author's transl)].

The effects of long-term treatment with synthetic oestrogens (Retalon retard, Sanabo Ltd., Wien, 5 mg/kg i.m. at weekly intervals) were investigated in 12 male rabbits and compared with the data obtained in 9 saline-treated control animals. After 6 months of treatment the oestrogen group showed significantly higher plasma phospholipid (p less than 0.005) and cholesterol (p less than 0.01) concentrations than the control group. However, histological examination of various important arterial vessels (the aorta and the coronary, cerebral, limb and renal arteries) revealed no pathological changes indicative of premature atherosclerosis in either the oestrogen group or in the control group. It is concluded that long-term treatment with synthetic oestrogens does not result in a higher incidence of atherosclerosis in rabbits.

Animals↗
PubMed1976

Steroidal compounds (injectable and implants) affecting spermatogenesis in men.

The effect of androgen and different progestins on spermatogenesis was studied in young men with subfertility, prostatovesiculitis and haematospermia, and in older men with benign hypertrophy of the prostate. The compounds (testosterone, testosterone oenanthate, ethinyl oestradiol, megestrol acetate, ethinyl norgestrienone and Depo-Provera) were administered intramuscularly, orally or as subcutaneous silastic implants.

Adult↗
PubMed1976

[Comparison of lipid concentrations in lung homogenates of newborns with and without hyaline membrane disease (author's transl)].

Quantitative and qualitative studies on lipids of the lungs were performed in babies who died during the perinatal period. The lungs were divided into organs with and without hyaline membranes respectively. Total lipids, phospholipids, neutral lipids, lecithins and sphingomyelins were determined. The fatty acid composition of total phospholipids and of lecithins is reported. A multivariate analysis of variance was used for the verification of significant differences in lipid content and in fatty acid composition with regard to the histological diagnosis. Taking at least two parameters (total phospholipids and C: 14-fatty acid or lecithin and C: 14-fatty acid into account, the two groups (lungs with and without hyaline membranes) were significantly different at the 5% level. The results are compared as well with the lipid content and composition of fatty acids of normal neonatal lung tissue as with observations regarding the lipids in amniotic fluid. The data obtained are discussed with regard to the development of lung maturity.

Amniotic Fluid↗
PubMed1976

[Comparison of serum lipid concentrations in umbilical artery, umbilical vein and maternal vein blood (author's transl)].

Maternal serum lipids and lipids in umbilical artery and umbilical vein blood were examined immediately after delivery in order to relate maternal and fetal lipid metabolism. Total lipids, phospholipids, triglycerides, total cholesterol, cholesterol esters and free cholesterol were determined. The comparison of arterial and venous umbilical lipid levels showed a significantly higher concentration of phospholipids in the umbilical vein, indicating an enhanced flux of phospholipids from the placenta to the fetus. A positive correlation is established for the amounts of total lipids (p less than 0,05), triglycerides (p less than 0,01), phospholipids (p less than 0,05) and free cholesterol (p less than 0,005) between maternal and umbilical vein blood. It is suggested that free cholesterol passes the placental barrier unchanged. The other correlations are discussed as the expression of a factor influencing simultaneously the maternal and fetal lipid metabolism.

Cholesterol↗