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G Bayraktar-Alpmen

Publications and source records attributed to G Bayraktar-Alpmen.

4 recordsLinked to original sources
PubMed1984

Effect of relative humidity on drug release from phenytoin sodium tablets and capsules. Part 1: Commercial preparations.

In this study the release rate of the active substance from different lots of commercial tablets and capsules of phenytoin sodium kept in different relative humidities (56, 75, 95%) was studied. It was observed that in both tablets and capsules, the effect of relative humidity and ageing was evident on the in vitro dissolution rate when compared with the in vitro dissolution profiles obtained before storage. The release rate differed from one lot to another after storage, the lots with higher release rates before storage in general showing a decrease and the ones with lower dissolution rates showing a higher release rate after storage.

Capsules↗
PubMed1984

Effect of relative humidity and ageing on drug release. Part 2: Experimental phenytoin sodium capsules.

In this study the effect of ageing and relative humidity on the release rate of phenytoin sodium was investigated for an experimental capsule formulation. Phenytoin sodium capsules containing lactose as the excipient were kept in 75 and 95% relative humidities, for 8 weeks, and the variances in the in vitro dissolution profiles of the active substance were observed. In vitro dissolution results were also evaluated kinetically. In general, it was observed that there was a decrease in the in vitro dissolution rate after storage at 95% relative humidity.

Capsules↗
PubMed1983

Studies on flufenamic acid capsules and tablets.

In this study, the in vitro dissolution rate of flufenamic acid was investigated in two different dosage forms, tablets and capsules, and the influence of the commonly used additives (lactose, corn starch, magnesium stearate, sodium lauryl sulphate). Using lactose, starch, Avicel PH 101, and methyl cellulose as additives, direct compression and wet granulation techniques were tried for preparing flufenamic acid tablets. The rotating basket method of U.S.P. XIX was used for determination of release rate. The findings were compared to the dissolution rate results of the commercial flufenamic acid capsules.

Capsules↗