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Biomedical subjects

G Beer

Publications and source records attributed to G Beer.

At least 37 records · Page 2Linked to original sources
PubMed1987

Long-term results of surgical repair of coarctation of the aorta--evaluation by exercise test.

Thirty-six patients have been operated on for coarctation of the aorta. The age at operation ranged from 4 to 45 years with a mean of 14 years. Preoperative systolic blood pressure (BP) was above the normal mean + 2 SD in 34 (94%) of the patients. The surgical techniques used for correction of coarctation were: resection and end-to-end anastomosis (50%), resection and graft interposition (25%), patch graft angioplasty (22%) and subclavian artery to descending aorta bypass graft (3%). There was no hospital mortality. Systolic BP measured on hospital discharge available in 30 patients showed an average decrease of 26 mm Hg. The mean follow-up period in 16 of 30 patients (53%) was 7.2 years. All of these patients had a further decrease in systolic BP, and in 14 of 16 (87%) BP was within the mean + 2 SD. Twelve patients were examined in the vascular diagnostic laboratory to determine adequacy of the repair by hemodynamic measures. After average of 7.8 years following operation, all of them had ankle systolic BP higher than brachial systolic pressure; ankle BP did not drop after treadmill walking exercise and the directional Doppler velocity curves from the legs were normal. This study suggested that BP continued to decrease after hospital discharge. We were unable to demonstrate correlation between age at operation and decrease in BP. The adequacy of surgical repair can be assessed by mild effort stress test combined with ankle/arm ratio measurement and directional Doppler velocity curves.

Adolescent↗
PubMed1982

Influence of physical activity on the thermic effect of food in young men.

Oxygen consumption and heart rate of young fasting men were examined at rest and during 2 h following food intake (400 or 1,200 kcal mixed or 1,200 kcal high-protein diet). In a series of experiments, this procedure was carried out after complete recovery from moderate exercise (10 min at 50% maximal aerobic power) performed immediately after the meal. The calorigenic effect of food was exhibited by all subjects. The magnitude of the postprandial rise in oxygen consumption was related to the caloric content of food, being similar after mixed and protein-rich diets. Moderate exercise after meals augmented dietary thermogenesis.

Adolescent↗
PubMed1981

Role of the vascular laboratory in the diagnosis of aortic arch occlusive disease: Screening of 2000 patients.

A significant difference in bilateral systolic brachial artery pressures and the presence of systolic bruit over a subclavian artery suggests occlusive disease in the innominate or subclavian arteries. Two thousand patients with these signs underwent ultrasonography of the carotid, subclavian, and brachial arteries in our laboratory. Doppler recordings of a vertebral artery, with hyperemia testing of the ipsilateral arm, identified those with a subclavian steal syndrome. In each case, angiography confirmed the laboratory diagnosis. The effectiveness of corrective surgery was evaluated noninvasively. Illustrative cases are presented and discussed.

Journal Article↗
PubMed1981

[On the etiology of water excretion inhibition in Addison's disease].

Micropuncture experiments, performed on adrenalectomized rats disclosed an impairment of the hypertonic sodium chloride transport of the thick ascending limb of Henle's loop (the diluting segment). This transport inhibition was documented by a delayed time course of NaCl-concentration decrease within the diluting segment. Assuming a pump leak model of the hypertonic NaCl-transport, we calculated a 50% inhibition of the NaCl-transport velocity compared with controls. Dexamethasone treatment for 3 days led to a normalization of the impaired transport velocity. Both, the reduced GFR as well as the impaired free water clearance are functionally linked to the diminished transport capacity of the diluting segment by the tubuloglomerular feedback mechanism and the ADH mechanism respectively. A new hypothesis on the pathogenesis of the water excretion inhibition in adrenal insufficiency is discussed.

Addison Disease↗
PubMed1980

Intravenous regional guanethidine treatment in peripheral vascular disease.

Twenty-eight patients with spastic and obstructive vascular disease were treated with intravenous regional guanethidine (IRG). The drug was injected into the affected hand or foot in doses of 10 or 20 mg, respectively. Temperature and strain-gauge plethysmography curves of the extremity were recorded before treatment, and three to four times during the subsequent 10 days. The effects of IRG, as observed by clinical laboratory examinations, were good in 8 of 12 patients. But in patients suffering from Bürger's disease or from major vessel obstructive disease, the results were not as good. However, in most patients IRG proved beneficial in relieving pain, an effect which sometimes outlasted objective improvements. IRG treatment is a simple and safe method for prolonged chemical sympathectomy.

Adult↗
PubMed1980

Detection of accidental leg ischemia during aortoiliac reconstruction.

After surgery of the aorta and iliac arteries, perioperative information concerning the circulatory status of the legs is vital. In a consecutive series of 71 patients, segmental air plethysmography was used to monitor simultaneously pulse volumes in both legs. Accidental ischemia was detected in four patients, and immediate corrective measures were undertaken. Compared with other methods, plethysmography proved reliable and easy to use.

Journal Article↗