Biomedical subjects

G Beese

Publications and source records attributed to G Beese.

4 recordsLinked to original sources

PubMed2001

[Reconstruction modes following gastrectomy. Results of experimental and clinical controlled trials].

Reconstruction modes following gastrectomy. Results of experimental and clinical controlled trials. In animal experiments four reconstruction methods following gastrectomy were compared: Roux-en Y reconstruction with (n = 33) and without pouch (n = 50) and isoperistaltic jejunum interposition with (n = 26) and without pouch (n = 55). The results were mostly influenced by the extent of esophagitis, documenting the reflux reduction by a pouch. Weight gain was slightly higher following jejunum interposition.Roux-en Y pouch reconstruction with jejunum interposition with pouch was compared in a randomized controlled trial. The additional operative effort of jejunum interposition did not achieve benefits in outcome. Therefore, Roux-en Y reconstruction should be advocated as standard reconstruction. The second randomized controlled trial compared Roux-en Y reconstruction with and without pouch. After more than three years, there was an advantage in life quality for patients with pouch indicating that patients with a favorable prognosis following gastrectomy should be reconstructed with a pouch.

Anastomosis, Roux-en-Y↗

PubMed1994

[Experimental studies of the value of the pouch after gastrectomy].

AIM OF THE STUDY: Clinical relevant follow up parameters were used to examine the influence of an additional pouch for reconstruction after gastrectomy in Roux-en-Y technique and jejunal interposition in rats. METHOD: 3 months old rats were gastrectomized and reconstructed as follows: Roux-en-Y (RY n = 50), jejunal interposition (JI n = 55) and each of these combined with a jejunal J-pouch (RYP n = 33; JIP n = 26). Up to 9 months postoperatively body weight, hemoglobin, iron, total protein and amylase as well as the pouch volume and esophageal mucosa were followed up. RESULTS: All gastrectomized animals show deficiencies compared to non operated controls (n = 6). The severity depends on the type of reconstruction. The RY group overall has the lowest values; hemoglobin (9 month) 4.2 g/dl, body weight (6 mon) 77% total protein (9 mon) 47 g/l. JI causes less defect: Hb (9 mon) 8.3 g/dl, BW (6 mon) 109%, TP (9 mon) 61 g/l. Animals with additional pouch have better values than those with the similar type of reconstruction but without pouch; RYP: Hb (9 mon) 12.7 g/dl, BW (6 mon) 95%, TP (9 mon) 55 g/l; JIP: Hb (9 mon) 15.1 g/dl, BW (6 mon) 107%, TP (9 mon) 64 g/l. Hemoglobin and total protein do not significantly differ between the combination of interposition and pouch and the control group (p > or = 0.05). The volume of the pouch increases 1:3 during 6 months. Animals with pouch do not show severe reflux esophagitis as do those without pouch. CONCLUSION: With global follow-up parameters the postgastrectomy deficiency can be evaluated in this experimental model. Interposition combined with the pouch is superior to the other methods as demonstrated by less deficiencies. Furthermore the pouch serves as a functional food reservoir and as reflux barrier.

Anastomosis, Roux-en-Y↗

PubMed1994

[Postoperative behavior of gastrectomized rats in an open field after Roux-Y-reconstruction with and without pouch].

In a series of experimental studies on rat behavior following reconstructive surgery after gastrectomy the effects of Roux-Y-Pouch-technique (RY-P) as compared to Roux-Y (RY) alone were observed. 12 rats with RY-P and 13 rats with RY were tested on days 100-105 post surgery using the Open-Field-test paradigm. Feeding behavior and weight were additionally controlled. Data analysis of repeated measurement design (ANOVA) revealed significant group x time-interaction between type of reconstruction and exploratory behaviors (p < .01). Moreover, RY-P rats consumed more food (p < .001), had higher weight gain (p < .01), and tended to more normal defecation. Overall, results favour the more physiological type of reconstruction.

Anastomosis, Roux-en-Y↗

PubMedDate not supplied

Energy crisis.

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Energy Metabolism↗