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Biomedical subjects

G Beilman

Publications and source records attributed to G Beilman.

5 recordsLinked to original sources

Medical directors as partners in creating healthy work environments.

Relationships between nurses and physicians in the intensive care unit can range from collegial and supportive to dysfunctional and abusive. When there is trust, open communication, respect, and a sense of camaraderie, the work is still challenging but gets done: priorities are met and people feel good about what they are doing. When these key elements are missing, satisfaction on the part of staff and patients decreases and turnover and costs increase. More importantly, research findings suggest that improving collaboration and teamwork are more than "feel-good" exercises: patient outcomes of care can be jeopardized when nurses, physicians, and other members of the critical care team are not communicating or collaborating. The nurse manager and medical director of the unit, as leaders of this team, are responsible for ensuring not only that quality care is delivered to patients, but also that the environment is supportive to caregivers. Purposefully establishing a collaborative partnership and then modeling these behaviors to the rest of the team, and holding them accountable, are key steps in creating an environment that is healing to patients, families, and caregivers.

Critical Care↗

Selective digestive tract decontamination and vancomycin-resistant enterococcus isolation in the surgical intensive care unit.

Vancomycin-resistant Enterococcus (VRE) has emerged as a significant nosocomial pathogen in the surgical intensive care unit (SICU). We wished to test the hypothesis that the use of selective digestive tract decontamination (SDD) in the SICU affects the frequency of VRE isolation. A retrospective review of hospital records and the SICU database was performed using patients admitted to the SICU service for three or more days from January 1, 1996 to December 31, 1999 at our large tertiary-care teaching hospital. During this time use of SDD in selected patient populations decreased due to physician preference. Information gathered included length of SICU stay, presence of VRE infection or colonization, and use and duration of SDD protocol, vancomycin, and ceftazidime. There were 110 newly diagnosed VRE cases in the SICU during this time period. During the same time period 54 patients received SDD. Eight patients who received SDD had positive VRE cultures and seven had the initial positive culture after receiving SDD. Overall, 9.1% of eligible SICU patients received SDD, 18.5% of patients in the SICU for over 3 days had VRE, 7.3% of VRE patients received SDD, and 13.0% of the SICU patients who received SDD subsequently developed VRE. SDD use was not associated with VRE in univariate analysis. Logistic regression analysis showed higher odds ratios for SDD use in combination with vancomycin than for vancomycin use alone (OR=4.3 vs. 10.9). Odds ratios were over three times higher for SDD plus vancomycin plus ceftazidime use when compared to vancomycin plus ceftazidime use alone (OR=70.5 vs. 19.8). We conclude that administration of SDD alone did not correlate with increased VRE isolation, but that SDD use in conjunction with vancomycin and ceftazidime was associated with VRE isolation.

Antibiotic Prophylaxis↗

Pathogenesis of oleic acid-induced lung injury in the rat: distribution of oleic acid during injury and early endothelial cell changes.

Oleic acid-induced lung injury, a well-described laboratory model for acute pulmonary injury in the rat and other species, causes morphologic and cellular changes similar to human adult respiratory distress syndrome (ARDS). Experiments were performed to test the hypothesis that the initial event of oleic acid lung injury is damage of the pulmonary vascular endothelium by oleic acid, with subsequent pulmonary damage and inflammation. Oleic acid levels were followed in the lung and other tissues by measuring accumulation of 14C-oleic acid; the direct effects of oleic acid and other fatty acids on rat endothelial cells, alveolar type II cells, and hepatocytes in culture were determined. Lung tissue from treated rats was also examined by light and electron microscopy for evidence of endothelial cell damage. At 30 min after injury, oleic acid reached high concentrations in lung tissue as demonstrated by presence of radiolabel (3.24 x 10(-6) moles per gram of tissue), with counts in the lung nearly an order of magnitude greater than in any other organ measured. Oleic acid was present in the lung mostly as free fatty acid (85%), and was also present in the alveolar fluid supernatants, rather than being cell-associated (1.7 x 10(-7) moles vs. 1.1 x 10(-8) moles at 30 min). Oleic acid was toxic to endothelial cells after one minute of exposure at concentrations of 5 x 10(-4) M and above. Electron microscopy showed endothelial cell changes as early as 10 min after induction of injury in vivo, including the presence of endothelial cell blebbing.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗