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Biomedical subjects

G Bender

Publications and source records attributed to G Bender.

27 records · Page 2Linked to original sources
PubMed1975

Cardiopulmonary effects of fentanyl-droperidol, nitrous oxide, and atropine sulfate in dogs.

The cardiopulmonary effects of droperidol-fentanyl, nitrous oxide, and atropine were evaluated in 12 adult male Beagle dogs. All dogs were surgically instrumented with a cardiac output thermistor and arterial and venous catheters and were prepared with a chronic tracheostomy. Each dog was used as its own control, and data obtained when dogs were nonanesthetized and nonmedicated were compared with data recorded after the test drugs were administered. The dogs were randomly allotted to 3 groups of 4 dogs each. Group I dogs were given droperidol-fentanyl alone intravenously (IV); group II dogs were given droperidol-fentanyl IV with 67% nitrous oxide; and group III dogs were given atropine sulfate intramuscularly followed by droperidol-fentanyl IV with 67% nitrous oxide. Minute volume was decreased in the 3 groups of dogs for 3 to 5 minutes after droperidol-fentanyl was injected. This resulted in respiratory and metabolic acidosis in all dogs, as indicated by increased arterial carbon dioxide tension, decreased pH, and increased base deficit. In addition, droperidol-fentanyl given alone caused a decrease in systolic pressure and a slight decrease in heart rate. Group 1 dogs were sensitive to auditory stimulation. Cardiovascular changes were not seen when nitrous oxide was added; however, analgesia and muscle relaxation were improved. Premedication with atropine sulfate resulted in increased cardiac output, heart rate, and diastolic pressure, and subsequent administration of droperidol-fentanyl with nitrous oxide caused a transient increase in mean arterial and systolic pressure. This last anesthetic regimen, along with assisted or controlled respiration, seems to provide an excellent anesthetic state with minimal cardiopulmonary depression.

Analgesia↗
PubMed1975

Effect of dobutamine in postperfusion cardiac failure in the dog.

The effect of dobutamine on cardiac function of dogs was investigated. Sixteen dogs were submitted to cardiopulmonary bypass. The aorta of each dog was cross-clamped for 1 hour; attempt was not made to perfuse the heart. After 1 hour, 8 of the 16 dogs were randomly selected and treated with dobutamine (5 mug/kg/min). The other 8 dogs were designated the control group and were given placebo. Postperfusion failure and death were used as end point criteria. Dogs given dobutamine responded remarkably well, with significantly decreased postperfusion low output syndrome. Evidence of cardiac function 5 minutes after the removal of the bypass was the criterion used to determine survival of the surgical cross-clamp procedure; however, this did not necessarily indicate survival of the dog. Of the 8 dogs given dobutamine, 6 (75%) survived the surgical cross-clamp, whereas of the 8 dogs not given dobutamine, 3 (37.5%) survived the surgical procedure. Seemingly, the effect of dobutamine is not mainly chronotropic, but is rather a direct aid to myocardial strength.

Animals↗
PubMedDate not supplied

A case of fetal parvovirus B19 myocarditis, terminal cardiac heart failure, and perinatal heart transplantation.

We report a case of fetal cardiomegaly secondary to myocarditis as a result of intrauterine parvovirus B19 infection. The fetus was delivered through caesarean section because of increasing deterioration of cardiac function at 33 + 3 weeks with reverse flow in the ductus venosus. Four weeks later, a cardiac transplantation was carried out because of therapy-resistant dilative cardiomyopathy. This case shows that fetal parvovirus B19 infection may occur without anemia and myocarditis and does not always result in spontaneous reformation of a dilated heart and normal recovery. It may become the determining prognostic factor for the child.

Adult↗
PubMedDate not supplied

[Investigations into methionine metabolism in normal and disturbed gestation on the basis of animal experiments].

One hundred and fifty Han Wistar rats, divided into three groups, non-pregnant controls, pregnant animals and pregnant animals with disturbed gestation, were each given an injection of 10 muCi 75-Se-methionine, administered into a tail vein--in the case of the two pregnant groups on the 20th day of gestation. The disturbance of gestation in the third group had been caused by ligating the uterine vessels on the 17th day of gestation. This resulted in a reduction in the number of live fetuses and a significant growth retardation in surviving fetuses which had lain close to the site of the ligature. Ten animals of each group were killed 30, 60, 180, 360 and 1440 minutes after the methionine injection and the activity in the blood, liver and fetoplacental unit was measured. From the measured activity (divided by the specimen weight and multiplied by the total weight of the animal divided by the activity of the injected dose) the relative organ activity was calculated; its duration may be regarded as a measurement of the nature and extent of methionine metabolism. It was found that the increase in amino-acid metabolism (especially in the liver) which takes place in pregnancy is less pronounced in cases of disturbed gestation. In the fetoplacental unit a high level of transmethylation activity was found. When gestation is disturbed, transmethylation is also increased, while in contrast a reduced rate of protein synthesis was observed. The division of the unit into fetus and placenta shows that the high transmethylation activity only takes place in the fetus, corresponding to the enzyme pattern in the fetus and placenta. The redistribution of fetal methionine utilization in favor of transmethylation where gestation is disturbed is systemically controlled. Simultaneously there is a localized, circulation-dependent, absolute reduction in diaplacental transport.

Animals↗