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Biomedical subjects

G Benita

Publications and source records attributed to G Benita.

4 recordsLinked to original sources
PubMed1985

[Changes in free and total thyroid hormones and reverse T3 in adult male rats during fasting].

The serum levels of thyroid hormones (T3, F.T3, RT3, T4 and F.T4), cholesterol and triglycerides were measured in a population of adult male rats subjected to experimental fasting. Comparison of bindings with results published in the literature reveals certain disagreements attributable to individual variations in the animals resulting from physical or physiological factors. This study demonstrates that deiodination of thyroxine in T3-Reverse has an economic role on a metabolic level. Evaluation of the T3/RT3 ratio appears to provide an indication of the homogeneity of the peripheral metabolism in an experimental population.

Animals↗
PubMed1981

Radioimmunoassay of serum thyroglobulin. Technique and clinical results.

A radioimmunoassay technique using a double antibody procedure for human serum thyroglobulin (HTg) is described. Only antigen labeling with iodine-125 is performed extemporaneously, the other reagents being purchased commercially. Quality criteria were: sensitivity (2 microgram/l), interassay reproducibility (coefficient of variance, C.V. = 11%) and specificity are comparable with those of previously published techniques. Normal limits for serum HTg concentrations were established on the basis of 65 assays (33.0 +/- 21.20 microgram/l). In 69 subjects exhibiting goiters and cold nodules, the values observed were considerably higher and more dispersed (81 +/- 57 microgram/l); the same observation was made for the the cases of Basedow's disease studied. Patients who had undergone thyroid ablation for thyroid cancer exhibited a low or nondemonstrable HTg concentration, except for seven subjects showing osseous and/or pulmonary functionally active metastases of a differentiated cancer whose HTg levels were significantly higher (300-400 microgram/l). These results concur with several previous reports in emphasizing the interest of assaying serum HTg during the surveillance of differentiated cancers of the thyroid.

Humans↗