[Production and metabolic clearance rates of cortisol in primary hypothyroidism (author's transl)].
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Biomedical subjects
Publications and source records attributed to G Benoit.
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Plasmatic concentrations of thyroxine (T4-D-) and triiodothyronine (T3 RI) were evaluated in 32 Graves' diseases on treatment by carbimazol. Among 131 measures, T4 and T3 were dissociated in 56%, with T3 more elevated than T4 in 89%. Compensated hypothyroidism was frequently seen (35%).
We are reporting our 20 years experience in the cytological diagnostic study of prostatic cancer. We studied at the same time, urinary cytology and prostatic histology in 217 patients. There were 50% false positive results with urinary cytology. Franzen aspiration enabled us to diagnose 81% of all prostatic cancers. These two methods are possible on an out-patient basis and enable us to determine high risk patients and to diagnose prostatic cancer earlier.
The authors have studied 36 cases of duodenal diverticula detected during 500 biliary operations. Initial pre-operative diagnosis was based on upper gastrointestinal barium series alone. Fiberopticduodenoscopy was unable to detect the diverticula. Patients were studied by cholangiocinesimetry. This technic demonstrated that oddian activity was satisfactory, with normal sphincter pressures and thus eliminated any suspicion of odditis. In this series, diverticula of the duodenal window lead to no more complications than do cholelithiasis, acute cholecystis or acute pancreatitis. The repercussion of the diverticula seems then to be limited to isolated dilatation of the common bile duct. In treating, the authors conclude that, in case of common bile duct dilatation, external drainage or biliodigestive anastomosis is recommended. Sphincterotomy is not indicated. All direct surgery on the diverticula, responsible for heavy morbidity and mortality rates, is to be avoided.
In the last 10 years we observed 75 cases of obstructive anuria: 60% during the course of pelvic cancer; 27% took place on a remaining kidney; 26% were due to kidney stones, usually uric acid stones; 3 cases were secondary to remaining kidney hydronephrosis. Diagnosis was facilitated by high dose, late film IVP and by descending uteropyelograms, one of the most reliable diagnostic techniques in trigonal obstruction. Hemodialysis was used in 10% of the cases. Early surgical treatment was often made possible by the use of spinal anesthesia.
24 of all patients observed between 1974 and 1976 suffering from thyrotoxicosis were found to have increased blood thyroxine (T4) levels without increased triiodothyronine ones. T4 hyperthyroidisms represented 3.5% of all hyperthyroidisms observed; they were in relation with Grave's disease (18 patients) or toxic nodular (6 patients); clinical pictures were quite usual; old age, severe illnesses, amiodarone and corticoids treatments, iodine excess, were sometimes being incriminated, but often no particular cause could be found. Preferential T4 secretion or impaired peripheral T4 conversion are two possible mechanisms of T4 hyperthyroidism.
The place of chemotherapy inthe treatment of urological cancers remains imprecise. According to numerous publications, all urological cancers should benefit from chemotherapy. This review's goal is to point out the benefits that may be obtained with this type of treatment. Reduction of tumor volume, improvement of quality of survival, length of survival and toxic side effects are taken into account. Two different situations are considered: cases in which chemotherapy has proved to be efficient and should be prescribed, and, in most cases, situations in which chemotherapy is designed to help finding active drug and define efficient therapeutic protocols. This can only be indicated when prospective randomised studies are done in specialised centers with the collaboration of urologists and radiotherapists.
The authors report a case of perinephric phlegmon simulating a tumor. Ultrasound and CT scan were unable to provide grounds for correct diagnosis. It was only after incision of the mass and drainage of the purulent matter that a correct diagnosis could be made.
This article provides a macroscopic and microscopic anatomical study of the structure of Denonvilliers' fascia, and suggests that it is embryologically connected with the anlage of the Wolffian duct, prostate and trigone.
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