Biomedical subjects
Publications and source records attributed to G Bergeret.
We report a 56 year-old woman with a severe axonal neuropathy due to a chronic intoxication by a cough soothing (Codobromyl). Symptoms of codeine and alcohol intoxication were present. The problems of self medication are considered.
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Two cases of strokes in the vertebrobasilar territory were observed in patients with Horton's disease during the first week of treatment when the inflammatory process seemed clinically and biologically under control. The mechanisms of arterial ischaemia are discussed: specific localisation of giant cell arteritis, associated atherosclerosis, failure of therapy or a possible inducing role of steroid therapy as the chronology of these cases would suggest.
TwO cases of megaloblastic anaemia, of which one was very severe, occurring in women who had been taking oestrogen-progestogen oral contraception over a long period of time, are reported. The authors take the opportunity, after having reviewed the literature, of pointing out the role of oestro-progestogen products in bringing about vitamin deficiencies. They discuss how and where oestrogen-progestogen products work on folic metabolism and emphasize that there is an associated factor which starts off the deficiencies.
Rheumatic manifestations due to Yersinia pseudotuberculosis are apparently rare. We report four personal observations, including one of a patient with Reiter disease and significant titres of antibodies to Yersinia pseudotuberculosis. In all four patients a non-specific syndrome, with fever and digestive symptoms, preceded the onset of joint disease. Both peripheral and axial joints were affected. One patient had HLA B27; the brother of another patient had spondyloarthropathy with HLA B27. Stool cultures were negative but they were all done at least three months after the acute episode. These rheumatic manifestations have many features in common with those described in Yersinia enterocolitica infections. Studies of larger series could improve our knowledge of the part played by the patients' constitution and widen the scope of reactive arthritis.
A case of spontaneous peritonitis in a cirrhotic patient is reported. Because of marked peritoneal and hemodynamic signs, exploratory laparotomy was decided on. Such cases of spontaneous peritonitis, which mimick surgical affections, are very uncommon. Onset is usually insidious with increasing hepatic fluid as the only sign. Bacteriologic examination of the peritoneal fluid is often negative. Diagnosis should be considered if cytology shows more than 75 polynuclear leukocytes per mm. When bacteriology is negative, association of an aminoside with penicillin G and metronidazole seems to be the most satisfactory combination.
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Simultaneous occurrence of "myasthenia gravis" and monoclonal "asymptomatic" gammapathy has been observed in a 83 years old patient. Antistriated muscle antibodies could be detected at a level of 1/1,000 but no antiacetylcholine receptors antibodies. The antibody activity is located both in the monoclonal IgG kappa and in the polyclonal IgG. This case illustrates the frequent occurrence of several auto-immune disorders in a same patient.
A 75-year-old woman developed a haemorrhagic syndrome due to an acquired deficit in factor X whic resulted in death from gastrointestinal bleeding. This deficit was associated with primary amyloidosis. The relationship between the two conditions, the particular features of the haemostatic picutre and the ineffectiveness of replacement therapy are discussed.
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Explore the source record for details and available documents.
The isolation of Cryptococcus neoformans from peritoneal fluid is a rare event. The authors present the case of a patient with a post-hepatitis cirrhosis and from whom C. neoformans was isolated from the ascitic fluid. The pathogenicity, the origin, the portal of entry of the yeast are discussed.
The authors report the observation of an entamoeba polecki infestation in a French woman in professional contact with pigs. Symptoms do not appear to be attributable to the amoeba-infestation but to an associated salmonellosis. The morphology and the pathogenicity of Entamoeba polecki are discussed.