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Biomedical subjects

G Bertoncini

Publications and source records attributed to G Bertoncini.

15 recordsLinked to original sources
PubMed2000

Ambulatory blood pressure monitoring in passive smoking and atropine--response in healthy volunteers.

AIM: The purpose of this study is to assess the effects of intravenous atropine on blood pressure (BP), systolic BP (SBP) and diastolic BP (DBP), after exposure of healthy volunteers to environmental cigarette smoking. METHODOLOGY: Seventeen non-smoking healthy volunteers (11 men and six women), aged from 20 years to 50 years (mean age: 31.3 +/- 8.7), were studied. These subjects received atropine under two conditions: first, in a 60 cubic metres of indoor space unpolluted by cigarette smoke; and second, in the same environment but polluted by 35 ppm carbon monoxide concentration reached by cigarette combustion. BP of each subject was recorded every 15 minutes for two hours by using an Ambulatory Blood Pressure Recorder BR 102. RESULTS: Mean baseline BPs in a smoke-free environment and in a smoking environment were respectively 120 +/- 18 mmHg and 120 +/- 25 mmHg for systolic values, and 81 +/- 6 mmHg and 84 +/- 9 mmHg for diastolic values (P > 0.05). After administration of atropine, mean BPs were respectively 126 (+/- 24)/80(+/- 7) mmHg in a smoke-free environment, and 131 (+/- 14)/ 90(+/- 2) mmHg after exposure to passive smoking (P > 0.05, no statistical significance). CONCLUSION: Our observations showed that BP varied but without statistically significant changes after acute exposure to passive smoking. However, it is known that any increase in BP leads to higher cardiovascular risks.

Adult↗
PubMed1993

Low dose lidocaine combined with magnesium sulfate in warning ventricular arrhythmias.

This study was designed to assess if low dose lidocaine (L) (0.8 mg/min at a constant rate infusion following a 100 mg bolus) combined with magnesium sulfate (M) (2.5 mg/min) controlled warning ventricular arrhythmias (a total of 119,806 ectopic beats and 146 runs of sustained ventricular tachycardia) in 7 (17%) out of 41 patients undergoing ambulatory monitoring. L alone was administered during the first 48 hours, then L+M for 48 hours, followed by L alone for a further 48 hours. Every 12 hours L serum levels were measured. Serum levels of L alone ranged from 0.33 to 2.06 mg/l (mean: 1.28 +/- 0.7 mg/l) during the first 48 hours and from 0.30 to 2.96 mg/l (mean: 1.24 +/- 1.02 during the last 48 hours). When the subjects received L+M, L serum levels were 0.69 to 3.28 mg/l (mean: 1.60 +/- 0.9 with p less than 0.05, statistically significant). Ambulatory monitoring also displayed a 70% reduction in warning ventricular arrhythmias during L+M treatment. L+M are more effective in the control of warning ventricular arrhythmias and we can also administer a lower dose of lidocaine when given in combination.

Aged↗
PubMed1993

Histopathologic coronary patterns in people with acute myocardial infarction and PTCA.

We studied coronary artery specimens histologically in 96 patients who died from acute myocardial infarction(AMI), to assess those who could benefit from in-hospital percutaneous transluminal coronary angioplasty (PTCA). For the left anterior descending artery, old stenoses within 1 cm from its origin in 80 cases (83.3%), coronary narrowing over 90% and occlusive thrombi in 40 observations (41.6%) were seen. Left main artery showed proximal stenoses with an occlusive thrombus in 4 cases (41.6%). Left circumflex artery had stenoses within 1 cm from its origin in 32 cases (33.3%), with an occlusive thrombus 6 times (6.25%) and coronary narrowing 75%. Right coronary artery showed stenoses in the proximal and midportion respectively in 20 (20.8%) and 36 cases (37.5%), with 26 occlusive thrombi (27%) and coronary narrowing 85%. Four cases (4.16%) had minimal coronary changes. The patients who had one, two and three vessel disease were 32 (33.3%), 32 (33.3%) and 28 times (29.16%) respectively. Only one-third of patients could benefit from PTCA.

Adult↗
PubMed1992

Postinfarction cardiac rupture in the nineties: do we know determinating factors?

Postinfarction cardiac rupture (PCR) up to the present accounts for approximately 20 percent of autopsy infarcted cases, ranking only behind arrhythmias and cardiac failure in the frequency of AMI complications. We re-examined our observations of a previous anatomo-clinical study of 96 patients who underwent autopsy after death from AMI. Sixteen patients had rupture of the free wall of the left ventricle at the site of infarction. All the patients with rupture showed the following statistically significant characteristics (p less than 0.01) if compared to those without rupture: cardiac hypertrophy (heart weight 390 to 1020 gm; mean: 627.5 +/- 201 gm; left ventricular wall thickness 18 mm to 29 mm; mean: 25.17 +/- 3.6 mm), sudden death (6 cases) without premonitory symptoms or with symptoms of less than an hour's duration or reappearance of chest pain not improved by opiates before late death, that occurred 240 to 660 minutes from chest pain, recorded electrocardiograms showing sinus rhythm with unchanged ST-segment (12 cases), atrioventricular block (2 cases) and junctional rhythm (2 cases). Hypertension pre-existing to the infarction was seen in 6 cases with rupture versus 9 cases without rupture (p less than 0.01). Blood pressure, heart weight and wall thickness of the left ventricle are the most increased parameters in the patients with PCR. Preventive measures against these factors can reduce PCR.

Aged↗
PubMed1984

[Circulating immune complexes in patients with lymphoproliferative and myeloproliferative diseases].

Circulating immune complexes have been studied with a competitive immune-enzymatic method on 9 controls, on 34 patients with lymphoproliferative disease (41.6 +/- 26.8) and in those with myeloproliferative disease (62.1 +/- 30) have been found significantly higher than in controls (20.3 +/- 14.1). The percentage of incidence of circulating immune complexes with values greater than 35 (normal value greater than 35) is found to be 58.8% in lymphoproliferative disease and 77.7% in myeloproliferative disease. Higher values of circulating immune complexes have been observed in patients with a depressed count of circulating monocytes, of lymphocytes with a dot-like alpha-naphthyl-acetate-esterase reaction and of nitroblue tetrazolium positive granulocytes, suggesting that circulating immune complexes can modulate cellular immune response as blocking factors.

Adolescent↗