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G Bertram

Publications and source records attributed to G Bertram.

At least 37 records · Page 2Linked to original sources
PubMed1989

Carcinoma of the nasopharynx--comparison of the UICC and Ho clinical staging systems.

From 1974 to 1985 definitive radiation therapy was performed in 76 patients with nasopharyngeal carcinoma (NPC). Of the 76 patients 59 presented UICC stage IV and 13 UICC stage III. The distribution of the stages was more homogeneous for the Ho system: Ho I, n = 4; II, n = 21; III, n = 16; IV, n = 32; V, n = 3. Radiotherapy followed the guidelines of the M.D. Anderson Hospital in Houston. A median dose of 68 Gy was given to the primary and of 66 Gy to the neck nodes, independent of the histologic subtype. The 5-year actuarial survival rate was 41% and the disease specific relapse-free survival (r.f.s.) 45%. Analysis according to the UICC classification and Ho's classification showed obvious deficiencies in both staging systems, but did not result in major prognostic differences. The freedom from local relapses correlated (P less than 0.05) with the T categories of the UICC at presentation (75% in T1 vs 45% in T4) and the freedom from distant metastases was significantly influenced by the cervical status (fixed cervical lymph nodes (UICC N3) vs, e.g., UICC N2: 51% vs 90%; P less than 0.05). In case of supraclavicular lymph nodes (Ho IV; Kyoto C) the freedom of distant metastases was lower than in case of upper cervical lymph nodes (58% and 79%, respectively; P = 0.3).

Adolescent↗
PubMed1989

[Radiotherapy technics and results in nasopharyngeal carcinoma at the Cologne University Clinics from 1974 to 1985].

At the university clinics of Cologne 76 patients were treated for nasopharyngeal carcinoma with curative intent from 1974 to 1985. The radiotherapy followed the guidelines of the M.D. Anderson Hospital, Houston and the Royal Marsden Hospital, London using a multiple field technique. A median dose of 68 Gy megavoltage radiotherapy was given to the primary and of 66 Gy to the neck nodes independent of the histologic subtype. The determinate relapse-free survival was 45% after five years and the local relapse-free survival 61%. The multiple field technique allowed to reduce the dose to the parotid. Only 25% of the patients suffered from a dry mouth after one year and only 10% after four years.

Adolescent↗
PubMed1988

Microheterogeneity of paraproteins. I. Diagnostic value of isoelectric focusing followed by immunoblotting.

Isoelectric focusing (IEF) in thin-layer polyacrylamide gels followed by immunoblotting on nitrocellulose membranes is presently the most sensitive method in the routine detection of IgG paraproteins. With this technique, immunoglobulin class and light chain composition can be as reliably identified as in immunoelectrophoresis. The problem of firm adherence between IEF polyacrylamide gels and nitrocellulose membranes can be overcome by brief incubation in sodium dodecyl sulfate. After isoelectric focusing, IgG paraproteins display a characteristic pattern of limited electrophoretic heterogeneity. This pattern is easily recognized even in the few cases with a constant tendency to aggregate under IEF conditions and in the surprisingly high percentage of paraproteins with very alkaline isoelectric points in which it is altered due to a cathodal collection effect. It is independent of the total amount of IgG in serum and remains stable intraindividually over extended observation periods. On the other hand, there is a very high degree of interindividual variability while common paraprotein characteristics still remain recognizable.

Acrylic Resins↗
PubMed1986

[Stapes anomaly, Gorlin-Goltz and hand-foot-uterus syndrome as partial aspects of a generalized ectodermal-mesodermal abnormality syndrome with variable expression].

A case of a Gorlin-Goltz-syndrome with anomalies of the stapes and incus of one ear is described for the first time. In the reported case, the hand-foot-uterus-syndrome could be recognised simultaneously. In the literature, about 250 cases of the syndrome are known, first published by Gorlin and Goltz in 1960. Malformations of the middle ear, however, have not yet been described in the Gorlin-Goltz-syndrome. As in the reported case both of the syndromes, the Gorlin-Goltz-syndrome and the hand-foot-uterus-syndrome, could be diagnosed, it must be discussed whether there are two independent syndromes or only one syndrome of polyvalent malformations characterised by variable expressivity.

Adult↗
PubMed1985

[Malignant lymphomas of the orbit, facial bones and the parapharyngeal space].

The evaluation of 21 patients with non-Hodgkin-Lymphoma and primary extranodal manifestations involving the orbits, the paranasal sinuses, and the parapharyngeal spaces shows no typical features in malignant lymphoma. The analysis of the morphological features in computed tomography allows no classification of the tumor type. The most important differential diagnoses within the region of the facial skeleton are discussed.

Adolescent↗
PubMed1984

[Diagnosis and therapy of syphilitic changes of the skin and mucous membrane in the head and neck].

Since the mid seventies the German Federal Board of Statistics has recorded a decrease in the incidence of the classical venereal diseases gonorrhoea and syphilis. This decrease is based only on a decline in the morbidity of gonorrhoea. Statistics on syphilis show an increase, from about 6000 to 8900 new cases each year, that is an increase of 48% between 1974 and 1978. Some cities such as Cologne, with a total of 401 new cases each year, show an increase, while numbers in rural regions remain unchanged or show a slight decline. Between 1978 and 1980 at the ENT and Dermatologic OPC of Cologne University many ulcers of uncertain aetiology in the head and neck region have been diagnosed as primary or secondary syphilis or as unusual presentations of this disease. In our Department a primary lesion of the head and neck was the presenting symptom in about 6% of all newly diagnosed cases. The differential diagnosis of early syphilitis lesions in the head and neck, the present position of serological diagnosis, and the current treatment of syphilis are illustrated by selected typical lesions.

Adult↗
PubMed1983

Epstein-Barr virus-related lymphocyte stimulation inhibitor: a possible prognostic tool for undifferentiated nasopharyngeal carcinoma.

It is demonstrated in this study that a serum factor, a lymphocyte stimulation inhibitor (LSI), which inhibits Epstein-Barr virus (EBV)-induced lymphocyte stimulation, is a potentially useful tool in the diagnosis and monitoring of nasopharyngeal carcinoma (NPC). In a study of 25 patients with undifferentiated NPC, 20 healthy controls, and 20 patients with other head and neck tumors, LSI was found only in the NPC patients with active disease. In a more complete study of 8 patients longitudinally followed up for at least 20 months, a comparison of LSI with antibodies to a variety of EBV antigens including viral capsid antigen, early antigen, and nuclear antigen indicated that LSI levels provided a reliable and sensitive indicator of disease activity that should be added to clinical markers currently in use as monitors of disease activity in NPC.

Adult↗
PubMed1982

Sera from patients with undifferentiated nasopharyngeal carcinoma contain a factor which abrogates specific Epstein-Barr virus antigen-induced lymphocyte response.

A unique association of Epstein-Barr virus (EBV) with the undifferentiated nasopharyngeal carcinoma (NPC) is a well acknowledged phenomenon. We report here the detection of a factor present in the sera of NPC patients which inhibits the blastogenic response of lymphocytes from EBV seropositive individuals to EB virions or soluble antigens. This lymphocyte-stimulation inhibitor (LSI) was found to be associated with the IgA fraction of the serum immunoglobulins. No inhibitory activity was detected in the sera and their immunoglobulin fractions from healthy (both EBV-seropositive and seronegative) individuals and patients with other carcinomas of the head and neck region. Interestingly, the IgA-LSI was absent in the sera of NPC patients who were successfully treated and remained in remission, while it was readily detectable in the sera of NPC patients in relapse, LSI-positive IgA fractions did not inhibit mitogenic response of lymphocytes to phytohemagglutinin. Taken together, the data presented suggest that LSI is a specific inhibitor of the response of sensitized lymphocytes to EBV antigens and that it may indeed represent a marker of great clinical significance regarding undifferentiated nasopharyngeal carcinoma, particularly for its prognosis.

Antigens, Viral↗
PubMed1982

[The assessment of the function of the nervus intermedius by means of functional salivary gland-scintigraphy].

Using functional scintigraphy of the salivary glands, the function of the nervus intermedius can be assessed by estimating excretory quotients for both submandibular glands. This method is preferred to the standard salivation test method of Magielski and Blatt, despite a minimal exposure of the patient to radiation from the injected Natriumpertechnetat. The technical course of this investigation, along with the indications for its use, will be presented.

Facial Nerve↗
PubMed1982

[Nasopharyngeal carcinoma (NPC): comparison of clinical staging-systems].

A group of 54 patients with nasopharyngeal carcinoma (NPC) has been classified according to the TNM-staging-systems of the UICC (International Union Against Cancer), DAG (German Work Group "Clinical Oncology"), J.H.C. Ho/Hong Kong and the 2nd International Symposium on NPC, Kyoto 1977. For several parameters the patients have been classified for AJC (American Joint Committee for Cancer Staging and End-Results-Reporting), too. Tumor extension to the base of the skull or pterygopalatine fossa can only be assessed by radiological techniques. Therefore 36 of the 54 patients have been examined for osseous lesions of these regions with both conventional and computerized tomography. New computed tomographs with high resolution power give better information about tumor involvement than conventional tomography. The value of X-ray methods for correct staging of NPC are demonstrated. A review of the results showed that the staging system of Ho is the most reliable of the staging systems. The other staging systems ie. UICC and DAG need considerable improvement before they can be recommended.

Female↗
PubMed1982

[Lymphoepithelial carcinoma of the oropharynx: incidence and differential di].

From 1960--1980, 452 malignant tumors of the oro- and nasopharynx were observed in the Cologne university ENT-clinic. 313 tumors of the oropharynx and 119 of the nasopharynx could be reclassified using the current classifications of upper respiratory tract tumors (WHO and Cologne modification) and of malignant lymphomas (German Kiel and Rappaport classifications). The analysis showed a different distribution of histological diagnoses in the naso- and oropharynx. Whereas the squamous cell carcinoma dominates with 57% in the oropharynx it is seldom seen (only 13%) in the nasopharynx. The non-keratinizing the undifferentiated carcinomas showed an inverse distribution in both regions. Malignant lymphomas and other types of malignant tumors occur equally frequent in the naso- and in the oropharynx. Only patients with non-keratinizing and undifferentiated carcinomas of the nasopharynx showed elevated antibody titers against Epstein-Barr virus. 7 patients with tumors of the same histological type but localization in the oropharynx had no elevated antibody titers against EBV.

Adult↗
PubMed1982

[Computed tomography of the nasopharynx and fossa pterygopalatina ].

CT is--especially since the introduction of thin slice technique--the method of choice for the diagnosis of nasopharyngeal tumors. This method provides better results than the conventional film tomography in determining intracranial tumor extension, osseous destruction of the base of the skull, and involvement of the orbit. Tumor infiltration into the pterygoid fossa is also well seen by the third generation of CT. In particular CT scans are superior to conventional tomography in delineating tumor extension to the parapharyngeal and retromaxillary space as well as in recognition of cervical lymph node involvement.

Carcinoma, Squamous Cell↗
PubMed1981

Histological types of nasopharyngeal carcinoma as compared to EBV serology.

One hundred and thirteen cases of nasopharyngeal carcinoma (NPC) were classified histologically according to the WHO-, French and Cologne systems. The various histological tumor types were then correlated with data on Epstein-Barr virus (EBV) serology (EA, VCA, EBNA, CF, IgA-VCA). The results showed non-keratinizing carcinomas with lymphoid infiltration, and undifferentiated carcinomas to be associated with significantly elevated anti-EBV titers. These two tumor types can be easily grouped together according to the French classification scheme as "undifferentiated carcinoma of the nasopharyngeal type (UCNT)". Such a procedure, which may have therapeutic implication, simplifies the rapid diagnostic screening of NPC patients and also may enhance the reproducibility of histological tumor typing.

Antibodies, Viral↗
PubMed1981

[Prolactin producing adenomas of the pituitary gland with primary localization in the sinus sphenoidalis (author's transl)].

The radio-immuno-assay of the pituitary hormone prolactin represents the basis for a functional differentiation of the so-called chromophobic adenomas. Two thirds of these tumors produce this hormone. For a long period of growth these adenomas are localized in the middle of the sella turcica. Their first direction of growth is towards the sinus sphenoidalis. At the ENT-clinic of the Cologne University two prolactin producing adenomas have been detected as the cause of suspected changes of the sinus sphenoidalis. The need for an endocrinological diagnosis in cases of unknown processes of the sinus sphenoidalis, the indication for surgery, and the medicamental treatment of these tumors with 2-Br-alpha-Ergocriptine (Parlodel) is discussed.

Adenoma, Chromophobe↗