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Biomedical subjects

G Besson

Publications and source records attributed to G Besson.

At least 37 records · Page 2Linked to original sources

[Pituitary adenoma secreting somatotropic hormone. Gigantism and peripheral neuropathy. A case].

Gigantism, an extremely rare condition, develops before puberty or in subjects in whom puberty is not yet completed. Hypersecretion of somatotropic hormone results in a tremendous surge in growth (our patient was 2.36 m tall). Among other clinical symptoms disabling peripheral neuropathy predominates and changes in nerve conduction velocity are not merely due to the increase in height. The increase in growth hormone concentrations combined with hypogonadotrophic hypogonadism with normal prolactinaemia is associated with peculiar cutaneous symptoms and with low levels of sex hormone-binding protein.

Adenoma

[Intramandibular segment of Meckel's cartilage in the rabbit embryo. Its cytological expression and osteogenetic fate].

Meckel's cartilage undergoes typical endochondral ossification within a model of the mandible, the ossification of which is then intramembranous. The concurrent development of two different osteogenetic processes in the 28 day-old rabbit embryo results in the formation of a single bony framework. These observations are based upon the assumption that Meckel's cartilage is not merely a supportive, primitive shaft without a definite ontogenetic future role, but rather an active participant in mandibular osteogenesis.

Animals

[VIP removes the inhibition of prolactin secretion induced by dopamine in patients with prolactinoma].

PRL responsitivity after Vaso-active intestinal Peptide (VIP) infusion was studied during a Dopamine (DA) infusion, in normal women and women with a prolactinoma. VIP alone (6.2 micrograms/min., 12 min.) increases PRL in normal females, but does not remove DA-induced PRL-decrease (1 microgram X kg X X min.-1). It has no effect in women with prolactinoma. In these women, PRL increases when VIP is administered at the 200th minute of DA infusion (1 microgram X kg/min.). A PRL release by VIP in women with a prolactinoma, could imply the restitution of a DA inhibitory control. The same dose of VIP does not modify PRL, when administered during a 4 microgram X kg/min. infusion of DA, in women with a prolactinoma.

Dopamine

Extra-dural hematoma of the posterior fossa (author's transl).

10 cases of posterior fossa extra-dural hematoma are reported and 100 other published cases reviewed. It appears that the sole clinical evaluation frequently leads to wrong or delayed diagnosis. In only one out of five cases the cerebellar signs and the palsy of one or several cranial nerves (VII, IX, X, XI, XII) are prominent. In contrast, all other cases do not present specific signs. Furthermore, the presence of a concomitant supratentorial traumatic lesion may contribute to prevent the finding of evidences for cerebellar extra-dural hematoma. The possibility for such hematoma must always been kept in mind when an occipital fracture is shown by radiography. Venous phases in carotid arteriography permit to ascertain the extradural hematoma if there is a displacement of the torcular Herophili or of the transverse sinus. Data from carotid arteriography may be normal and the lesion may be ascertained by vertebral arteriography which will demonstrate: anterior displacement of the basilar artery against the clivus--anterior displacement of posterior inferior cerebellar and posterior meningeal arteries--crescentic displacement of brain substance from the inner table--displacement of the venous sinuses.

Adult

[Selective ventriculography according to the Corrales technique. Its value in the diagnosis of tumors of the 3d ventricle and posterior fossa].

The authors relate their experience of selective ventriculography. The methode previously described by CORRALES needs a small gold chain with fine links which can reach by gravity the cavity of the fourth ventricle through the third ventricle and the aqueduct of Sylvius. This small chain is used as a leader for a flexible catheter which permits selective clouding of median ventricular cavities. This technique was used in 18 patients. In one case only, the small chain went down without any difficulty into the cisterna magna. The ventricular system was normal. In the 17 other cases, the progression of the small chain was stopped at some point of the ventricular cavities. In each of those cases, the stopping of the small chain appeared to be linked with the presence of a growth directly obstructing or compressing the ventricular cavities and gave a first clue as to its location. Introduction of the catheter into the aqueduct of Sylvius was the only true difficulty; in 3 cases, anatomical (large massa intermedia) or pathological obstacle (right angle bending of the aqueduct of Sylvius) made it impossible. In those 3 cases a satisfactory selective clouding of the fourth ventricle was nevertheless obtained by injecting the dimer either into the posterior part of the 3rd ventricle or into the upper part of the aqueduct of Sylvius. In all cases the trouble some superpositions due to clouding of lateral ventricles were thus avoided and a tomographic investigation, specially useful for the diagnosis of expanding lesions of the third ventricle and posterior fossa was allowed.

Brain Neoplasms

"Head yourself".

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Community Participation

[Carotid-cavernous fistulas by tearing or rupture of the meningo-hypophysial trunk or of one of its branches. Anatomo-radiologic study of 4 cases. Pathogenic hypotheses].

Thr authors report observations relative to four cases of traumatic carotid-cavernous fistulas for which angiographic pictures were similar. Autopsy examination permitted in two cases to establish that the tentorial branch of the meningo-hypophyseal trunk was involved in the genesis of both fistulas. One case was from a rupture, the other from tearing of that branch. Further examination of these two cases showed an absence of sphenoid bone fracture which suggested that any arterial perforation or shearing process could be excluded. Thus the pathogenic hypothesis of PARKINSON is further sustained. The authors suggest that the observed arterial lesions may be due to tensions occuring at the proximal part of branches of the meningo-hypophyseal trunk. Such tensions may be carried out through tractions on the posterior meningeal walls of the cavernous sinus when trauma occur on the posterior temporal area and the petrous bone. Such traction forces were shown to be real in one case where a fracture of the dorsum sellae and a bilateral caroti-cavernous fistula were caused by a bilateral temporo-petrous trauma.

Adolescent