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Biomedical subjects

G Binetti

Publications and source records attributed to G Binetti.

At least 91 records · Page 5Linked to original sources
PubMed1987

Hemodynamic effects of felodipine in congestive heart failure.

The hemodynamic effects of increasing dosages of felodipine, a new calcium antagonist with selective vasodilator properties, were studied in 13 patients with chronic cardiac failure. A Swan-Ganz thermodilution catheter was positioned in the pulmonary artery and hemodynamic parameters were monitored from 9 am to 6 pm for five days. On the first and the fifth day patients received placebo (P) and on the second, third, and fourth day patients received felodipine 5, 10, and 20 mg, respectively. Symptom-limited exercise tests with a bicycle ergometer were performed on both days of P and on the fourth day. A marked reduction of systemic vascular resistance (SVR) and a significant increase of cardiac index without increments of heart rate (HR) were observed after felodipine at rest. A dose response effect could be demonstrated. During exercise a significant increment of cardiac index and decrease of pulmonary wedge pressure was observed after felodipine. Felodipine showed a potent vasodilator action on systemic circulation with significant changes on both stroke volume and filling pressures at rest and during exercise without side effects.

Exercise↗
PubMed1985

Genetic heterogeneity of hypertrophic cardiomyopathy.

We studied the pattern of inheritance of hypertrophic cardiomyopathy among 111 first-degree relatives of 30 patients with the disease. Results of segregation analysis suggest a genetic heterogeneity for hypertrophic cardiomyopathy in that both autosomal dominant and autosomal recessive mode of inheritance can occur.

Cardiomyopathy, Hypertrophic↗
PubMed1985

[Clinical and hemodynamic results after aneurysmectomy and coronary revascularization].

To assess the effects of left ventricular aneurysmectomy (l.v.a.) on left ventricular function (l.v.f.), a prospective clinical and hemodynamic study has been performed in nineteen patients (pts) operated on from 1979 to 1983. There where no operative deaths and only one late death during follow-up. A significant improvement in NYHA class was observed in 68% of the pts, 16% worsened, and the clinical status in the remaining 16% was unchanged. Hemodynamic data showed an increase in e.f. (33 +/- 12% to 43 +/- 10%; p less than 0.001), a reduction of the percentage of the abnormally contracting left ventricular segments (66 +/- 23% to 57 +/- 23%; p less than 0.05) and no significant changes of left ventricular end diastolic pressure. Revascularization index (nr. of bypassed vessels/nr. of stenotic vessels) and graft patency rate were low (0.57 and 0.72 respectively). No significant relation was noted between clinical and hemodynamic findings in the postoperative study. We conclude that l.v.a. is associated with an improvement of l.v.f. (mainly in e.f. and segmental wall contractility) and of clinical status of the pts but without a direct relation between these two parameters.

Adult↗
PubMed1984

Echocardiographic evaluation of the response to afterload stress test in young asymptomatic patients with chronic severe aortic regurgitation: sensitivity of the left ventricular end-systolic pressure-volume relationship.

The detection of myocardial depression is an important goal in the management of patients with chronic severe aortic regurgitation but may be quite difficult at an early stage by the conventional basal measures of contractility. The response to afterload stress determined by angiotensin challenge and the end-systolic pressure-volume relationship was evaluated echocardiographically in 16 asymptomatic or mildly symptomatic patients with chronic severe aortic regurgitation, ages 15 to 56 years (mean 32 +/- 12). Nine normal subjects, ages 25 to 41 years (mean 31 +/- 5), served as a control group. In the group with aortic regurgitation, end-systolic dimensions were greater than 55 mm in five of 16 patients and fractional shortening was 25% or less in two of 16. In the control group angiotensin caused a decrease of stroke volume index in six out of nine patients (15% at the most) and a mild increase in three. In the group with aortic regurgitation stroke volume index decreased by 15% or more of the basal value in nine of 16 patients and increased or decreased by less than 15% in seven of 16. Ejection fraction decreased in both groups, from 61 +/- 6% to 52 +/- 7% in the control group and from 56 +/- 6% to 45 +/- 5% in the group with aortic regurgitation. Ventricular function curves were derived by relating end-diastolic volume index to stroke work index; seven of 16 patients had abnormal responses reflecting an afterload mismatch.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1983

Prenalterol in primary dilated cardiomyopathy: hemodynamic and angiographic evaluation.

The hemodynamic effects of an acute infusion of prenalterol (PN), a new inotropic beta-adrenoceptor agonist, have been evaluated by cardiac catheterization in 10 patients with primary dilated (congestive) cardiomyopathy. A single dose of 20 micrograms/kg was administered over 5 min after basal hemodynamic and angiographic measurements. The administration of prenalterol caused a significant increase in mean cardiac index, from 2.3 to 3.3 l/min/m2 (P less than 0.01) and mean stroke volume, from 47 to 62 ml (P less than 0.01) without a change in heart rate. Mean left ventricular end-diastolic pressure was reduced from 19 to 13 mm Hg (P less than 0.05) and left ventricular dp/dt rose from 902 to 1089 mm Hg/s (P less than 0.01). Stroke work index increased from 27 to 40 g m/m2 (P less than 0.01) and ejection fraction from 31 to 36% (P less than 0.05). Mean blood pressure did not change and the systemic vascular resistance decreased from 24 to 17 RU (P less than 0.01). The favorable effect of prenalterol on left ventricular relaxation was shown by an increase of peak negative left ventricular dp/dt from 946 to 1159 mm Hg/s and by a decrease of the time constant of left ventricular pressure fall from 49 to 39 s. These results demonstrated a positive inotropic effect of prenalterol on patients with diffuse and severely reduced contractility.

Cardiac Output↗
PubMed1981

[Rupture of interventricular septum and ventricular aneurysm secondary to acute myocardial infarction in a case with normal coronary arteries (author's transl)].

A patient with ventricular septal defect and ventricular aneurysm after an acute myocardial infarction with normal coronary arteries is reported. Heart failure at 3 weeks after acute myocardial infarction was the indication for surgical treatment. The patient was successfully operated upon with resection of the aneurysm and closure of the ventricular septal defect. Coronary angiography performed before and after cardiac surgery demonstrated a normal coronary tree with transient systolic subocclusion of the left anterior descending coronary artery. The implication of a muscular bridge on the complications of myocardial infarction are discussed.

Heart Aneurysm↗