PubMed Health⌕ Search

Biomedical subjects

G Blair

Publications and source records attributed to G Blair.

At least 19 recordsLinked to original sources
PubMed2001

The pathogenicity of Clostridium difficile.

It is now well established that the major virulence factors of C. difficile are the two toxins A and B. However, the organism possesses an array of other putative virulence factors that may be important for localisation within the colon, and in evasion of the immune system. It has been observed that certain types of C. difficile are more commonly found causing disease than others, and this seems to be independent of toxin production. Is this simply a reflection of their abundance in the hospital environment, or is it due to their virulence determinants? This review covers our current knowledge of the modes of action of toxins A and B at the cellular and molecular level. Many unanswered questions are posed that require answers before we can fully understand the pathogenic mechanisms of the organism and be in a position to manage better the spectrum of diseases it causes.

Bacterial Proteins↗
PubMed1997

Nurse education: a time for new solutions?

Notes the worsening situation with regard to nursing shortages. Considers responses such as the commission of increased places on Project 2000 courses and the introduction of NVQ III staff. Points to this success, particularly with regard to the latter of these solutions, but notes a lack of career progression for such entrants. Suggests that there is a strong case for development of a better career path for NVQ III staff, and looks to education and training consortia in this respect.

Career Mobility↗
PubMed1995

Delivering comprehensive services to homeless mentally ill offenders.

A consortium of social services agencies developed a comprehensive community mental health services program for homeless mentally ill offenders in Portland, Oregon. Residential services were provided in a single-room-occupancy hotel. Forty-seven clients were accepted for the program, 38 actually entered the program, and 14 graduated--that is, attained sobriety and were placed in community housing. Problems complicating program implementation included differing philosophical approaches of key agencies, staff turnover, and financial shortfalls. Many potential clients were not accepted into the program because of recent violence or potential violence; some clients were expelled or reincarcerated because of violent behavior.

Adult↗
PubMed1994

Long-term continuous ambulatory peritoneal dialysis in diabetics.

Of 147 diabetic patients with end-stage renal disease who were treated in our CAPD program between 1978 and 1991, 6 men and 1 woman (5 had type II and 2 type I diabetes) with a mean age of 54 (range 21-70) years have been on CAPD for more than five years (mean: 76 mos, range: 65-109 mos) and on peritoneal dialysis (IPD+CAPD) for an average of 85 (range: 67-118) mos. They had a variety of comorbid conditions at the start of CAPD: Retinopathy (5/7), blindness (3/7), hypertension (5/7), peripheral neuropathy (7/7), peripheral vascular disease (3/7), congestive heart failure (3/7), myocardial infarction (1/7), ischemic heart disease (2/7). Two were smokers and five over the age of 65. Peritonitis rate was 1 episode/11.4 pt mos, exit-site infection 1/76.4 pt mos and average hospitalization rate 32.8 days/patient/year. Hypertension was well-controlled with discontinuation of all medications; after initiation of CAPD two of them remained without medications throughout the study but in the rest, medications had to be restarted. As assessed by HbA1c, blood glucose control improved with IP administration of insulin. Residual renal function progressively decreased. None of them developed severe hyperparathyroidism. Peripheral neuropathy remained stable in four and deteriorated in two. Total protein, albumin, cholesterol and triglycerides decreased during the last two years indicating a degree of malnutrition. Our experience with these seven patients suggests that diabetic patients, even the aged and those with many comorbid conditions and complications, can survive for long periods on CAPD.

Comorbidity↗
PubMed1988

Inflammatory pseudotumors in children.

Inflammatory pseudotumors are so named because they mimic malignant tumors clinically and radiologically. Most often seen in the lungs of young adults, they consist of localized proliferations of mononuclear inflammatory cells and myofibroblasts. There are scattered reports of these tumors occurring in various sites in children. We report five cases of these rare lesions in children; four arising intraabdominally and one in the lung. In contrast to the usual presentation in adulthood, these children were all previously healthy. One child, with the tumor arising from the urinary bladder, was originally diagnosed as having a malignant sarcoma and underwent pelvic exenteration and chemotherapy for this subsequently-proven benign lesion. Local recurrence occurred in one case. Total excision is indicated and is usually possible without unacceptable morbidity. Our cases and a review of the literature point out the importance of pathologic differentiation of these lesions from malignancy with early appropriate surgery.

Child↗
PubMed1987

Mother-child transactions in families with normal and handicapped children.

This paper describes two aspects of mother-child interaction: children's contribution to early conversations and mother's tactics for eliciting verbal responses. Normal and handicapped children matched for linguistic complexity (mean length of utterance) differed in both qualitative and quantitative aspects of their verbal interactions with their mothers. Normal children talked more, responded correctly more often, and made more attempts to control the conversation than mentally retarded children. Clear differences in mother choice of tactics for eliciting child verbalizations also were evident between the two groups. Overall, mothers of handicapped children modeled responses more and frequently asked fewer and less complex questions. The differences in mother behavior appeared to be a function of the child's specific skills, and not of the child's general classification as normal or mentally retarded; patterns of mother linguistic adjustment were identical in the two groups. These findings are discussed in terms of a general model of transactional linguistic teaching in dyads with mentally retarded children.

Child↗
PubMed1986

Chronic intussusception due to antral myoepithelioma.

Intussusception was seen on abdominal sonography and computed tomography in a 15-year-old boy who presented with a 6-week history of weight loss, vomiting, abdominal pain, abdominal mass, and hyperamylasemia. Laparotomy revealed a chronic gastroduodenal intussusception, the lead point of which was an antral myoepithelioma, a rare entity in this age group.

Adolescent↗