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Biomedical subjects

G Bo

Publications and source records attributed to G Bo.

At least 19 recordsLinked to original sources
PubMed1987

Identification of vaginal lactobacilli from asymptomatic women.

In the present work, carried out by means of phenotypic and genotypic tests, it has been demonstrated that none of the vaginal lactobacilli isolated from asymptomatic women were genetically close to L. acidophilus ATCC 4356. Strains of homofermentative lactobacilli were identified as Lactobacillus gasseri, L. jensenii and L. crispatus, while in the heterofermentative only one strain was classified as L. fermentum. Moreover a genetically homologous group of heterofermentative lactobacilli, that could represent a new species, were evidenced.

DNA, Bacterial↗
PubMed1977

Hydrostatic pulmonary edema in the cat. Effects on pulmonary blood and water volumes and on lung compliance.

The effect on lung compliance of changes in intra- and extravascular volumes has been studied. Such changes were induced by inflation and deflation of a balloon placed in the left atrium in open-chest cats. Blood constituents were labeled with isotopes, and tissue water content was found from the wet/dry labeled with isotopes, and tissue water content was found from the wet/dry weight ratio. When left atrial pressure (PLA) was elevated to a value not exceeding 32 mmHg (4.256 kPa), there was only a minute increase in tissue water volume, and we observed a reversible reduction in lung compliance related to the rise in lung blood volume. At higher PLA, a rapid rise occurred in extravascular fluid volume, with evidence of alveolar flooding. Earlier experiemtns have shown that, in isolated perfused lung, a situation of slow, steady increase in interstitial fluid can be created. This does not seem to be the case with lungs in situ: once the lymphatic drainage is unable to cope with transvascular fluid flow, an unstable situation is created. This rapidly leads to alveolar flooding and a fall in compliance in addition to that caused by a rise in blood volume. From our fluid and pressure determinations, we calculated a filtration coefficient (Kf) of 0.45 ml/100 g wet lung X cmH2O X h. This is within the range reported for sheep lungs. Observation of dynamic lung compliance cannot be used for detection of interstitial fluid accumulation. It appears, however, that in contrast to isolated lungs, this phase of edema-formation rapidly leads to alveolar flooding.

Animals↗
PubMed1977

Alveolar pressure and lung volume as determinants of net transvascular fluid filtration.

We have investigated the influence of changes in alveolar pressure (PAlv) and in lung volume on the net transvascular fluid filtration rate (FFR). The preparation was isolated, perfused zone III rabbit lungs. In observation periods the outflow pressure was kept constant at a level generally causing net filtration. All pressures were measured relative to atmospheric. FFR was measured by continuous monitoring of preparation weight. Elevation of Palv at constant lung volume caused reversible reductions in FFR, also at constant capillary hydrostatic pressure (Pa-V less than 2 Torr). Increases in lung volume at constant PAlv caused reversible increases in FFR. When both PAlv and Ptp were increased a reduction in FFR was seen in the majority of cases. We conclude that at constant pulmonary arterial pressure, the size and the direction of the influence of positive airway pressure on FFR depend on the relative change in lung volume and in alveolar pressure per se. Under the present experimental conditions a rise in PAlv will be transmitted to interstitial fluid pressure and affect the transvascular fluid balance.

Animals↗
PubMed1977

Hypoxanthine levels of plasma during hypoxemia in dogs.

Tissue hypoxia was induced in one group of dogs by clamping of the endotracheal tube and in another group by artificial ventilation with a mixture of nitrogen and air. The hypoxanthine concentration of venous and arterial plasma increased significantly during severe hypoxemia. When the hypoxemia was relieved, an increased venous-arterial hypoxanthine difference appeared indicating that the lung metabolism of hypoxanthine was slowed down during alveolar hypoxia. It is concluded that the level of plasma hypoxanthine in dogs during hypoxemia is dependent on the degree of tissue hypoxia, peripheral vasoregulation, and lung metabolism.

Animals↗
PubMed1976

Lung volumes and arterial blood gases in obesity.

Lung volumes and arterial blood gases have been studied in six severely obese patients (mean weight 143 kg), admitted for jejunoileal shunt-operation. The lung volumes were recorded on a Siemens constant volume body plethysmograph, and the arterial blood gases were measured by means of a Radiometer ABL-1 blood gas analyzer. The patients were in the seated body position. The Functional Residual Capacity (FRC) was found to be 40% (mean value) of Total Lung Capacity (TLC). Predicted normal value of FRC/TLC% in non-obese subjects of the same height, sex and age is 54%. During tidal breathing the arterial oxygen tension (PaO2) was 84 mm Hg (mean value) compared to 95 mm Hg in non-obese subjects. A positive correlation between FRC/TLC% and the PaO2 was found. A series of 5 deep breaths normalized the PaO2 which rose by 18 mm Hg to 102 mm Hg (mean value). These results confirm the generally held opinion that the main abnormality of lung function in obesity is a reduction of lung volume to such a low value that airway closure occurs during tidal breathing, causing arterial hypoxemia.

Adult↗
PubMed1975

Effects of catecholamine-infusions and hypoxia on pulmonary blood volume and extravascular lung water content in cats.

The effects of catecholamine-infusions and of hypoxia on lung blood volume and on extravascular lung water content have been studied in anesthetized cats with opened chests. To this end a biopsy technique, with isotope labelling of blood and with successive removal of the smaller lung lobes, was employed. Mean pulmonary arterial pressure increased by 30-75% upon infusing catecholamines or upon inducing general hypoxia, the latter stimulus being the more powerful one. Pulmonary blood volume did not increase during these procedures, where an active constriction of pulmonary vessels thus apparently took place. The extravascular lung water content was found to be reduced in animals infused with noradrenaline or ventilated by hypoxic air, whereas a small increase was observed in the animals receiving adrenaline. This difference might reflect domination of precapillary vasoconstriction in the former groups, whereas postcapillary vasoconstriction could be more pronounced with adrenaline.

Animals↗