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Biomedical subjects

G Bohn

Publications and source records attributed to G Bohn.

At least 19 recordsLinked to original sources
PubMed1992

[Reevaluation of breath alcohol concentration with Alcotest 7410].

To examine the applicability of the Alcotest 7410 machine for preliminary testing of breath alcohol systematic investigations were performed. After the end of drinking alcohol blood samples were taken in series from one person and parallel breath tests were carried out. Under the conditions used for the blood sampling by the police breath tests were carried out on 168 subjects 1-5 mins after the bloodsampling. The suitability of the Alcotest 7410 machine as a preliminary test for breath alcohol is discussed.

Alcoholic Intoxication↗
PubMed1990

[Sudden infant death--fatal poisoning with pheniramine].

A case of unintentional fatal intoxication of a 10 month-old baby with the anti-histamine Pheniramine (Avil) is reported. On the face value and without an autopsy this case parallels familiar cases of SIDS and had for this reason been certified as such. Autopsy, however, revealed 32 partly dissolved tablets which proved to be Phenyramine. High concentrations of Pheniramine were found in body fluids and various tissues. According to official investigations, the tablets were offered to the baby by his 3 1/2 year old sister who probably believed they were sweets.

Brain↗
PubMed1989

[Forensic medicine and toxicologic aspects of 2-propanol poisoning].

Two cases of poisoning with 2-propanol (isopropylalcohol) are reported. In one case, nail polish remover was drunk by a 2-year-old child. The concentration of 2-propanol and its metabolite acetone in the blood could be observed over a period of approximately 50 h. The highest concentration of 2-propanol determined was 4.22 g/l. Acetone reached a maximum value of 2.27 g/l 12 h after ingestion. The child survived without any observable after-effects. In the second case, a 35-year-old man drank ethanol in addition to 2-propanol. The poisoning was lethal. The possible time of intake before death is discussed in relation to the estimated levels of ethanol, 2-propanol and acetone found in the blood and urine. The histomorphological findings are often important as well with regard to time of intake.

1-Propanol↗
PubMed1989

[Child abuse or accidental poisoning with isopropanol?].

Child-maltreatment or accidental poisoning with Isopropanol? A 2 1/2 year-old child was treated for scalding three weeks before an intoxication with isopropanol. During the clinical investigation in connection with the intoxication many hemorrhages of different ages were found. The massive intoxication with isopropanol could be controlled successfully by intensive medical treatment. Because of the circumstances and the method of administration of the isopropanol, the possibility of a rare form of child maltreatment is discussed.

1-Propanol↗
PubMed1985

[Rectal methohexital--anesthesia induction of choice in children?].

Rectal application of methohexital for induction of anaesthesia takes into consideration the child's psychological state. However, quite a lot of side effects may occur that are not dependent on age or body weight but on dosage. A clinical study with 66 children from nine months to seven years of age was performed to find out the most adequate dose of methohexital for rectal application. Three groups of children were given, 20, 25 and 30 mg methohexital/kg BW, respectively. Results obtained suggest 25 mg methohexital/kg BW to be the most adequate dose. Failure of induction was seen in 6%. Side effects like respiratory depression, excitation and unexpectedly high plasma levels of methohexital should be considered possible. Methohexital plasma levels of more than 22 micrograms/ml were obtained. Correlation between the effect and side effects of methohexital on the one hand, and maximal plasma levels on the other, were not seen. Since rectal application of methohexital in fact means induction of anaesthesia it should be given only in the presence of an anaesthesiologist and adequate anaesthesia equipment.

Anesthesia, General↗
PubMed1976

[Investigations of the decomposition and detection of morazone by thin-layer- and gas-liquid-chromatography].

Three decomposition products of Morazone (ingredient of the pharmaceutical preparation Rosimon-Neu) were observed following heat treatment in acid medium (hydrochloric or tartaric acid). These products were isolated by TLC and identified as bis-antipyryl-methane, phenmetrazine and 4-hydroxymethyl-antipyrine by mass spectrometry and IR-spectroscopy and 1H-nuclear magnetic resonance. Morazone and the metabolite phenmetrazine may be extracted from alkaline urine using chloroform, however acid hydrolysis (pH 1) of the urine before alkaline extraction will improve the sensitivity of detection of morazone by producing the metabolite phenmetrazine in addition to bis-antipyrylmethane. The metabolite 4-hydroxymethyl-antipyrine is barely detectable by TLC from alkaline extraction of urine.

Antipyrine↗