Biomedical subjects

G Bonin

Publications and source records attributed to G Bonin.

3 recordsLinked to original sources

PubMed2003

Phenolic compounds content in Pinus halepensis Mill. needles: a bioindicator of air pollution.

Foliar phenol concentrations (total and simple phenols) were determined in Aleppo pine (Pinus halepensis Mill.) needles collected in June 2000, from 6 sites affected by various forms of atmospheric pollutants (NO, NO(2), NO(x), O(3) and SO(2)) monitored during two months. Results show an increase in total phenol content with exposure to sulphur dioxide and a reduction with exposure to nitrogen oxide pollution. p-Coumaric acid, syringic acid and 4-hydroxybenzoic acid concentrations increase with exposure to nitrogen oxide pollution, whereas gallic acid and vanillin decrease in the presence respectively of sulphur dioxide and ozone. This in situ work confirms the major interest of using total and simple phenolic compounds of P. halepensis as biological indicators of air quality.

Air Pollutants↗

PubMed1999

[In Process Citation]

This study focuses on how allelopathic mechanisms may be involved in the floristic composition and dynamics of Cistus albidus shrubbery. Allelopathic potential of essential oils was measured for Lactuca sativa (toxicity for other species) and Cistus albidus (self-toxicity). These oils have little effect on germination but significantly increase, even in low quantities, the number of unviable seedlings and inhibit normal seedling growth. These results explain, at least partially, the existence of monospecific stands over several years and the lack of natural regeneration of the Cistus albidus populations. Bioassays performed using natural aerial leachates of Cistus albidus revealed no significant effects on the above-mentioned parameters. Leaching does not seem to be an important means of allelochemicals release. Nevertheless, essential oils have been quantified in litter and soil, indicating a possible occurrence of allelopathy in such ecosystems.

Journal Article↗

PubMed1993

Chimeric EWS-FLI1 transcript in a Ewing cell line with a complex t(11;22;14) translocation.

Peripheral neuroectodermal tumors include the differentiated neuroepithelioma and the undifferentiated Ewing's tumor. Despite clinical and pathological differences, both malignancies are characterized by a t(11;22)(q24;q12) translocation which is observed in > 90% of the cases. Molecularly, the translocation is underlaid by a rearrangement between the EWS and Fli-1 genes on chromosomes 22 and 11, respectively. Because of the difficulties in the differential diagnosis between various small round cell tumors of childhood, including Ewing's tumor, a molecular diagnostic assay would be desirable. A prerequisite for predicting the reliability of such a test resides in the molecular elucidation of the peripheral neuroectodermal tumor cases which do not exhibit the prototypical translocation. We have analyzed one such case of Ewing's tumor-derived cell line with a t(11;22;14)(q24;q12;q11) translocation. An EWS-Fli-1 fusion transcript was evidenced by polymerase chain reaction amplification of a reverse transcription product obtained from total RNA. Direct sequencing was performed to demonstrate that the molecular rearrangement in this particular Ewing sample resulted in a fusion transcript similar to those observed in tumors with the prototypical translocation.

Base Sequence↗