Biomedical subjects

G Boon

Publications and source records attributed to G Boon.

5 recordsLinked to original sources

PubMed2005

[Value of biochemistry performed in pre-hospital cardiology].

For a long time, the diagnosis of an acute myocardial infarction (AMI) seen in outdoor patients, was only relying on ECG findings. For that reason a certain amount of patients suffering from an AMI showing an atypical or not contributive ECG had not been identified as such and in consequence did not benefit from any prehospital treatment or had not been admitted in coronary care unit (CCU). With the arrival of the biological bed side monitoring in the SAMU, it became possible to measure via TRIAGE Cardiac the biological parameters of an AMI (myoglobin, troponin Ic and CKMB) and so confirm or exclude the diagnosis in certain cases. Other markers became measurable, such as BNP (brain natriuretic protein) a marker for early detection of heart failure. This natriuretic peptide is used during hospitalisation as a prognostic value in acute coronary syndrome with no cardiac insufficiency associated. More recently a semi quantitative test CardioDetect using the early release of h-FABP (heart fatty acid binding) showed a better sensibility in the first hours after chest-pain onset in out-door patients. The experience of the use of these biological bed side tests in the prehospital phase is only recent, but already permits a better management of out door patients. The future of there employ is promising. The combined use of these different markers in out door patients will probably allow in the near future identifying high risk patients.

Biomarkers↗

PubMed2005

[Antithrombotics in pre-hospital phase of acute coronary syndromes].

Antithrombotic therapies are the corner stone of acute coronary syndrome management. We have the proof that many of them should be initiated during the prehospital care because their clinical benefit is time-dependent. The hypothesis that anticoagulation therapy is an effective treatment of STEMI, which benefit is time-dependent, is now validated. It is also fair to affirm that GP lIb/IIIa receptor inhibitors are the adjuvant therapy of choice for primary PCI. Indeed, these medications reduce short-term and long-term mortality. This clinical benefit is time dependent. Clopidogrel therapy is probably also a medication of the prehospital phase. It is well established now that the biological efficacy of this pro drug is loading dose dependent. It is also demonstrated that its clinical efficacy depends on the time delay between symptom onset and initiation of the therapy. However, the clinical benefit of prehospital administration remains to be established.

Angina, Unstable↗

PubMed2000

The use of a phi(rhoz) model for simultaneous determination of composition and thickness in analytical transmission electron microscopy

X-ray microanalysis using transmission electron microscopy (TEM) offers the possibility to perform quantitative analysis with high spatial resolution. Disadvantages are its low accuracy and the problem of preparing very thin specimens and the thin film standards, needed for the analysis and calibration. To calculate composition from the measured X-ray intensities, a peak-ratio method is usually applied, based on the thin film method by Cliff and Lorimer (Proceedings of the Fifth European Congress on Electron Microscopy, 1972, p. 140). We however, applied an entirely different approach, calculating the composition using a full matrix correction method based upon a phi(rhoz) matrix correction model as they are commonly used in EPMA measurements up to 40 kV. The validity of the model under TEM conditions was checked by performing bulk analyses on AlNi and AlTi samples and thin film analyses on an AlNi TEM specimen. In principle, both thin and thick specimens as well as light elements can be analysed this way. No major changes to the TEM set-up or simplifications to the model are needed, only an accurate beam current meter is required.

Journal Article↗

PubMed1989

[Complaints about dentists].

Complaints against dentists can be lodged with the Dutch Dental Association. A content analysis was made of complainers' letters received in the years 1983-1986. Two third of the complaints concern dental treatment-especially crowns and bridges and careless behavior, 20% are about fees, 9% about communication and information and 3% are complaints from other dentists. Of all complaints at least 30% are rooted in a faulty communication between dentist and patient. Complaints about fees have strongly diminished, complaints about a second opinion have increased significantly. Most cases are resolved informally. Almost half of the complaints officially delt with is (partially) substantiated. Redressment of done injustice often is the imposed sanction, sometimes combined with a warning. Reprimande, suspension or expulsion are seldomly imposed. The authors stress the importance of prevention of complaints by better informing patients as well as more openness on dealing with complaints.

Dentist-Patient Relations↗

PubMed1980

Medicated early weaning to obtain pigs free from pathogens endemic in the herd of origin.

A field trial was conducted to assess the value of medicated early weaning for obtaining pigs free from some of the pathogens endemic in their herd of origin. The trial comprised 51 sows from a closed herd, which were farrowed in an isolated farrowing house in seven separate groups. The sows in each group were bred at the same time and induced to farrow on the same day. Their thriftiest piglets were weaned at five days of age and moved to an isolated early-weaning unit. At about six weeks of age they were moved to one of three isolated grow-out units where they were held to slaughter weight. Sows in five of the groups were dosed with high levels of tiamulin and trimethoprim-sulphonamide preparations from their entry into the farrowing house until their biggest piglets were weaned. Their piglets were dosed with similar drugs from birth until 10 days of age. The first and seventh groups of sows and their litters were not medicated. Tests were carried out on pigs aged five to 11 weeks, on slaughter pigs, and on pigs which died or were killed at different ages, for Mycoplasma hyopneumoniae, Bordetella bronchiseptica and colonic treponemes, which were readily detectable in the herd of origin. No evidence could be found of mycoplasma or bordetella. Colonic treponemes were recovered from some of the pigs at slaughter, but not from younger pigs. Thirty-seven boars and gilts from the medicated groups were introduced into 11 herds thought to be free of enzootic pneumonia and 13 were introduced into three herds which had enzootic pneumonia. No subsequent signs of enzootic pneumonia were noted in 10 of the enzootic pneumonia-free herds.

Administration, Oral↗