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Biomedical subjects

G Bossi

Publications and source records attributed to G Bossi.

At least 73 records · Page 4Linked to original sources
PubMed1989

Changes in membrane properties of erythrocytes and polymorphonuclear cells in psoriasis.

Using fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene and its cationic derivative, 1-(4-trimethylaminophenyl)-6-phenyl-1,3,5-hexatriene, we evaluated membrane fluidity in living polymorphonuclear leukocytes and in erythrocytes of psoriatic patients. Our results have shown that erythrocyte membranes of psoriatic patients exhibit a decrease of fluidity. These changes were not associated with any relevant modifications of the cholesterol to phospholipid molar ratio. Moreover, we observed a decrease in polymorphonuclear leukocytes membrane fluidity associated with changes in chemotactic migration. Our results indicate changes of membrane fluidity involving membranes different from the epidermal cells and suggest the hypothesis of a defective membrane-cytoskeleton interaction in psoriasis.

Adolescent↗
PubMed1989

Membrane fluidity changes in polymorphonuclear leukocytes and erythrocytes in psoriasis.

We studied membrane fluidity in living polymorphonuclear leukocytes and in erythrocytes of 8 psoriatic patients, using fluorescence polarization of 1-(4-trimethylaminophenyl)-6-phenyl-1,3,5-hexatriene. In erythrocyte membranes of psoriatic patients we observed a decrease of fluidity, these changes were not associated to relevant modifications of the cholesterol to phospholipid molar ratio. Moreover, we observed a decrease in polymorphonuclear leukocytes membrane fluidity. Our results indicate changes in membrane fluidity involving membranes different from the epidermal cells and suggest the hypothesis of a defect in membrane-cytoskeleton interactions in psoriasis.

Adolescent↗
PubMed1982

[A study on 333 patients with adenocarcinoma of the endometrium treated by combined surgery and radiation therapy (author's transl)].

Three hundred and thirty-three consecutive patients with adenocarcinoma of the endometrium treated from 1958 to 1978 by combined surgery and radiation therapy or radiation therapy alone were reviewed. According to the FIGO staging system, there were 204 stage I, 40 stage II, 24 stage III and 20 stage IV. 40 cases of recurrences were also included in this study. The main parameters influencing survival were clinical staging, depth of myometrial invasion, histologic differentiation as well as the possibilities of radical surgery in these patients. Analysis of therapeutic results shows the superiority of pre-operative intra-cavitary irradiation followed by total abdominal hysterectomy and bilateral salpingo-oophorectomy with an 80% actuarial survival at five years in stage I. Primary surgery followed by radiation therapy gives inferior results, particularly in stage II. Treatment by radiation therapy alone should be reserved for inoperable patients after careful evaluation and gives a 35% actuarial survival at five years. The incidence of serious therapeutic complications was 3,6 %. The early diagnosis of endometrial carcinoma by means of systematic endo-uterine explorations in post-menopausal bleeding and the elaboration of combined multi-modality protocol prior to any treatment should lead to a better cure rate for this cancer of increasing incidence.

Adenocarcinoma↗
PubMed1977

[Blastogenetic activity of medullary blood serum of patients with various blood diseases].

Peripheral blood lymphocytes from 24 patients were cultured in vitro in the presence of autologous peripheral serum and bone marrow blood serum, with and without PHA stimulation. Bone marrow serum showed a well defined effect, in the absence of PHA stimulation, on lymphocytes from 4 patients (2 affected by acute leukaemia, 1 by megaloblastic anemia and 1 by benign idiopathic paraproteinaemia), and a less defined effect on lymphocytes from 2 donors (1 affected by iron deficiency anemia and 1 by thalassemia minor). No difference attributable to the source of blood serum was observed in PHA stimulated cultures. These results do not allow defined statements. Peripheral blood lymphocytes cultured in vitro were affected by bone marrow blood serum only in some subjects. A clear cut correlation between this effect and the clinical features of our patients was not evident.

Anemia, Megaloblastic↗
PubMed1977

[Clinico-radiological studies on 3 cases of bezoars].

Three cases of phytobezoar (2 in the stomach and 1 obstructing the ileum) are presented. The bezoar described are due to persimmon in one cases and to applies in two cases and have been observed during a period of over 10 years.

Adult↗