Biomedical subjects

G Bourdon

Publications and source records attributed to G Bourdon.

3 recordsLinked to original sources

PubMed1991

[Liver transplantation and the major histocompatibility complex].

We have carried out a retrospective study over 308 liver transplant patients (31 of them have had a retransplantation) in Professor Bismuth's Department at Paul Brousse Hospital. The purpose of the study was a search for the possible effect of donor/recipient major histocompatibility complex on the evolution of the transplantation. We chose to study four parameters: early acute rejection; chronic rejection; retransplantation cases and death frequency; graft survival. We observed the following: for HLA A locus: in cases of total or partial compatibility there are more moderate early acute rejections than in the case of incompatibility (p less than 0.02); for HLA B locus: in the case of total compatibility there are more chronic rejections than in cases of partial or total incompatibility (p less than 0.03); for joint A and B locus: the results are similar to those of A locus (p less than 0.03); for HLA class I: we observed no effect either on graft survival or on retransplantation cases or on death frequency; for HLA DR: we did not find any effect on the studied parameters. Considering the low statistical significance of these results and in order to confirm our analysis, we have started a prospective study in collaboration with two other European Transplantation Centers.

Graft Rejection↗

PubMed1990

[Subcutaneous analgesic administration].

In March 1989, Saint Luke's Hospital in Montréal piloted the use of continuous and intermittent subcutaneous injection of analgesics. This practice involved patients whose pain could not be relieved by traditional methods of analgesic administration. The article describes the positive results of the project, and clearly identifies suitable patients. It also outlines the advantages, limiting factors and risks involved with each type of infusion. Procedures for set-up and monitoring are briefly explained. The authors conclude that family members of patients can be easily taught to perform the procedure at home.

Analgesics↗

PubMed1976

[Antitumoral immunity induced by the administration of homologous and isologous tumoral cells treated by moderate heating].

Treatment of tumour cells with heat ranging between 46 and 52 degrees C attenuates strongly their virulence and renders the tumour cells immunogenic to the host. By repeated administration of heat treated tumour cells suspended in Freund's complete adjuvant, the animals acquire a state of immunity which makes them tolerant to tumour inocula 100% lethal in the controls. The immunity so conferred is cell-mediated and can be adoptively transferred to isogenic recipients with donor peritoneal exudate and, to a lesser degree, splenic cells.

Animals↗