[Practical hints on thoracic radiology].
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Humans↗
Biomedical subjects
G Bozzola
Publications and source records attributed to G Bozzola.
Paclitaxel, ifosfamide, and carboplatin for the treatment of stages IIIB and IV non-small cell lung cancer: preliminary results.
We have treated 26 consecutive chemotherapy-naive patients with stage IIIB/IV non-small cell lung cancer with an innovative regimen based on a 1-hour infusion of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) 125 to 250 mg/m2, ifosfamide 3 g/m2 (with mesna), and carboplatin dosed to an area under the concentration-time curve of 5, every 21 days for a total of six cycles in responding or stabilized patients. Among 22 fully evaluable patients, 14 (64%) achieved a partial remission, six had disease stabilization, and two had disease progression. Hematologic toxicity was remarkably mild; only one patient had grade 3 neutropenia (on day 21). Arthralgias/myalgias (grade 3 in nine patients, grade 4 in one patient) and neurologic toxicity (a cumulative sensory neuropathy of grade 3 or 4 in five patients) were the most common side effects and seem to be dose related. To date, few patients are fully evaluable and survival data are clearly immature. Nevertheless, this regimen seems highly active and quite well tolerated, and deserves further evaluation.
Adult↗
Chylothorax after blunt chest trauma: an unusual case with a long latent period.
We report on a case of closed chest trauma with an unusual latent period of 11 weeks in a woman 26 years old. The patient had a dual thoracic duct with a dual lesion and was evaluated using lymphography and CT. We discuss the pathogenetic mechanism and the unusual radiological appearance with discontinuity of the duct, and an increase in back pressure which promotes dilatation of lymphatic vessels and nodes. The dual duct had two separate traumatic consequences: a chyloma on the right and leakage in the pleura on the left. Pleuroperitoneal shunting was effective after failure of conservative treatment. Two years after discharge the patient is asymptomatic with normal chest X-ray image. She is near term in a normal pregnancy and without signs of silent malignancy.
Adult↗
[Computerized tomography in the staging of bronchogenic carcinoma. Critical evaluation of 91 cases].
In reviewing 91 cases of bronchogenic carcinoma, traditional radiology (TR) and CT patterns were compared versus surgical/pathologic findings. CT always gave clearer assessment of the mediastinum and thoracic wall invasion. In the evaluation of metastatic spread to hilar and mediastinal lymph nodes the false negative rate was higher with TR than with CT; on the other hand, there was a higher false positive rate with CT. The advantage of CT in the staging of bronchogenic carcinoma is verified and a rationalized flow-chart which includes TR, endoscopy, CT and mediastinoscopy is suggested.
Adult↗