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G Bramanti

Publications and source records attributed to G Bramanti.

At least 37 records · Page 2Linked to original sources
PubMed1982

On the absorption, distribution and excretion of sorbinicate in the rat and the monkey.

Absorption, distribution and excretion of 14C-D-glucitol hexanicotinate (sorbinicate, SN) were studied after oral dosing in the rat against 14C-nicotinic acid (NA). SN is absorbed in large quantities from the gastro-intestinal tract, even if to a lesser extent than NA. The serum 14C-radioactivity after SN presents a distinctly different trend from that after NA administration: peak at 8 h (against 15 min for NA), slow excretion, very low and constant levels (peak 1/10 of that induced by NA). The superior performance of SN is explained partly by the different absorption of the two drugs and partly by a strong tropism for the tissues, especially for the liver, of which SN gave proof in the distribution tests. The excretion of 14C after SN in the urine is about half of that after NA whereas excretion in the feces is several times greater. Some results obtained in the monkey substantially confirm the findings in the rat.

Animals↗
PubMed1978

Effect of cicloxilic acid on the liver damage produced by a choline-free, high-fat low-protein diet.

The effects of cis-2-hydroxy-2-phenylcyclohexanecarboxilic acid (cicloxilic acid) on the liver damage produced by a choline-free, high-fat low-protein diet (Handler's diet) were studied in rats. Treatment with cicloxilic acid significantly counteracted the increase in liver weight, hepatic lipids, serum transaminase and ornithine carbamoyl transferase activities, caused by the unbalanced and deficient diet. Histological examination of the liver showed a near-normal structure of the hepatic cells in the cicloxilic acid-treated animals. Other antihepatotoxic and choleretic drugs, with which cicloxilic acid was compared, showed either much less protective activity or none at all. Furthermore, while cicloxilic acid (which exhibits choleretic activity) did not alter the hepatic glycogen content, another choleretic drug, 1-phenyl-1-hydroxypentane (PC 1), caused marked depletion. It is concluded that the protective activity exerted by cicloxilic acid on the liver is separable from its choleretic activity.

Animals↗
PubMed1978

Effects of cicloxilic acid on CCl4-induced liver injury.

The effects of cis-2-hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) on the liver injury produced by carbon tetrachloride poisoning were studied in rats. It was found that oral treatment counteracts the CCl4-induced increase in liver weight, rise of liver triglycerides, fall of plasma triglycerides and rise of serum transaminase and ornithine carbamoyl transferase activities. Further, cicloxilic acid, when administered alone, altered none of the parameters studied. Cicloxilic acid was found to be more effective at the lowest doses than any of the other antihepatotoxic and choleretic drugs used. When cicloxilic acid was administered at the highest doses, the plasma triglyceride level of the intoxicated animals was not significantly different from that of the controls. To find out whether cicloxilic acid was effective in maintaining a normal lipoprotein secretion after CCl4 poisoning, experiments were carried out with Triton WR-1339. The results indicate that cicloxilic acid maintains the output of triglycerides from the liver to the plasma compartment at near-normal level in CCl4 poisoned rats. Possible mechanisms for the effects of cicloxilic acid on the CCl4-induced liver damage are discussed.

Animals↗