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Biomedical subjects

G Brenner

Publications and source records attributed to G Brenner.

At least 55 records · Page 3Linked to original sources
PubMed1981

[The professional image of the general practitioner. Taking stock (author's transl)].

In order to maintain the necessary supply of general practitioners, by 1990 about 11,000 (44% of the present number) and by the year 2000 about 18,000 to 20,000 (about 75% of the present position) doctors must set up in general practice. 1000 to 1500 postgraduate places per annum must be reserved to guarantee the basic attention in general practice in future by "postgraduate" general practitioners. Preliminary medical treatment is no longer carried out exclusively by general practitioners. Only 60% of all original warrants for application for treatment per quarter are given to general practitioners; 40%, on the other hand went directly to specialists. In the last year a change has taken place in the patient's behavior at the first consultation. There has been a movement towards the specialist of about 2.5%.

Family Practice↗
PubMed1981

[Salts of 5-methylpyrazole-3-carboxylic acid with basically substituted adenine derivatives. Identification and lipolysis inhibitory activity (author's transl)].

5-Methylpyrazole-3-carboxylic acid forms salts with basically substituted adenine bases of type (4) or (5), which have significantly more lipolysis inhibitory activity than the free acid itself. The substance tested, 6-amino-9-[2-hydroxy-3-(N-methyl-N-2-hydroxyethyl)-aminopropyl]-purine-5-methyl pyrazole-3-carboxylate (16), causes a significant reduction of serum FFA levels in fasted rats, even at the very low dosage of 0.150 mg/kg b.w., whereas the free 5-methylpyrazole-3-carboxylic-acid shows significant activity in this model only at doses of 2 mg/kg b.w. and above. The salt also shows similar activity on serum triglycerides. The effect on FFA, triglyceride and cholesterol levels, respectively, in fasted rats lasts for at least 8 h.

Adenine↗
PubMed1977

Relocation of the aged: a review and theoretical analysis.

The literature on the relocation of the aged is examined and the findings are presented within a framework of three types of moves--institution to institution, home to institution, and home to home--with each type having a voluntary and involuntary component. A theoretical model is proposed to explain the often contradictory results reported in this literature. In brief, it is argued that an individuals' response to relocation is largely determined by (a) the perceived predictability and controllability of the events surrounding a move and (b) differences in controllability between pre- and post-relocation environments. The validity of this model is tested by examining existing research and suggestions for future research are made.

Aged↗
PubMed1975

[Enteral absoprtion of ascorbic acid in man after application of a micro-encapsulated retard preparation (author's transl)].

Blood level determinations of ascorbic acid were carried out in 11 male probands after oral application of a new vitamin C retard preparation. In comparative tests the same probands received identical doses of a non retarded vitamine C preparations after a period without application of 2 weeks. The results obtained show that after application of the new vitamin C retard preparation the absorption of ascorbic acid is increased and thus a marked improvement of the bioavailability of vitamin C is attained as compared to the non retarded form.

Administration, Oral↗
PubMed1975

[Nicotinic acid blood levels after application of xanthinolnicotinate in a new galenic retard preparation].

Nicotinic acid blood level determinations were carried out in 30 male test subjects following application of xantinol-nicotinate in a new galenic retard preparation. The investigations showed that there is a continuous absorption of the agent--lasting for a longer period--with a maximum of blood level values between the 5th and 7th hour. In comparative studies with non-retarded xantinol-nicotinate the peak of concentration is already reached 1 h after application. The use of pharmacokinetic methods showed that by the retardation of xantinol-nicotinate there are no losses of absorption of nicotinic acid--as compared with the non-retarded forms. By the special galenic properties of the new retard form therapeutically effective nicotinic acid blood levels lasting for more than 8 h with an ascertained biological availability are attained.

Adenosine Triphosphate↗