Biomedical subjects

G Bridgman

Publications and source records attributed to G Bridgman.

4 recordsLinked to original sources

PubMed1992

False contraindications to childhood immunization.

An immunization advisory clinic was set up in mid-Essex in 1988 to provide a referral facility for professionals and parents who were unsure about the eligibility of certain children to receive immunization. This paper describes four typical cases. The history and management of each case are described and the fact that all the children were successfully immunized is highlighted. It is hoped that by sharing the experiences of the immunization advisory clinic with other professional staff, more positive decisions regarding immunizations will be made.

Child, Preschool↗

PubMed1991

A micro-enzymatic method to measure cholesterol and triglyceride in lipoprotein subfractions separated by density gradient ultracentrifugation from 200 microliters of plasma or serum.

A micro-enzymatic method was developed to measure total cholesterol (CHOL) and triglyceride (TG) in lipoproteins and their subfractions separated by density gradient ultracentrifugation. This method had a detection limit and sensitivity below 2 mg/dl and accuracy (bias to reference sera) and imprecision (coefficient of variation) of less than 3% between 2 and 30 mg/dl for both CHOL and TG. In addition, the method was in good agreement with standardized Abell-Kendall CHOL (r = 0.98) and enzymatic TG (r = 0.99) methods. Lipoproteins from 200 microliters of plasma or serum were separated by either equilibrium (EQ)- or rate zonal (RZ)-density gradient ultracentrifugation and the resulting fractions were analyzed for CHOL and TG by the micro-enzymatic method. Lipoprotein measurements by these micro-enzymatic/density gradient methods were highly correlated with standardized Lipid Research Clinic (LRC) procedures and preparative ultracentrifugation. The EQ-density gradient procedure also allowed determination of CHOL and TG in LDL and HDL subfractions within any desired density interval. These methods will facilitate the measurements and study of lipoproteins and their subfractions especially in infants, children, the elderly, and small animals. In addition, the micro-enzymatic method may be adapted to other modes of lipoprotein separation such as liquid chromatography, electrophoresis, and precipitation. CHOL or TG determinations could be made on approximately 500 density gradient fractions per hour.

Adult↗

PubMed1980

A child trisomic for the distal part of chromosome 14q.

A child is described with multiple congenital abnormalities including microcephaly, odd facies, Fallot's tetralogy, and absent parathyroids. These were associated with partial trisomy for the distal half of the long arm of chromosome 14, the extra segment being translocated to the short arms of No 10. The main clinical problems were those related to the congenital heart disease and hypocalcaemia.

Chromosome Aberrations↗

PubMedDate not supplied

Evaluation of progress using the context input process and product model.

Most evaluations of programme effectiveness are based on process data (the data generated by the programme) and used for internal monitoring and service development. Context (the ecology of therapeutic systems), input (the identification of what is in fact different between two therapeutic systems) and product (the consequence of different inputs, taking account of context) evaluations are rarely, if ever, produced. In this paper (using input and product evaluations) the progress of twelve Down's syndrome and twelve multiply-handicapped children attending, over a period of 18 months, two different therapeutic systems operated by the New Zealand Society for the Intellectually Handicapped (Auckland Branch/outside Auckland Branches) is assessed. The progress of the Auckland children is significantly better in a number of areas than for those outside Auckland. This improvement in progress can be attributed to input differences that reflect the Auckland Branch's policy of service development. The most important determinants of a successful programme are not staff/student ratios, time in class or specialist assistance, all of which favour the outside Auckland groups, but the degree of structure, detail of programmes and assessments, and quality of parent contact in which Auckland seems superior. The results for the Down's syndrome group compare favourably with those from other Down's syndrome programmes.

Activities of Daily Living↗