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Biomedical subjects

G Brooks

Publications and source records attributed to G Brooks.

65 records · Page 4Linked to original sources
PubMed1982

Urinary bladder dysfunction as a remedial disability in multiple sclerosis: a sociologic perspective.

Forty-two patients formed the sample for this study. They represented a self-selected subset of 115 patients who complained of bladder dysfunction as a disability secondary to multiple sclerosis. The study generated data on previous management and results, subjects' desired current intervention goals, urodynamic evaluation, and current intervention outcomes. Results indicated that bladder dysfunction disabilities are either ignored or mismanaged and that the disability can be reduced to the patient's satisfaction using clinically available diagnostic methods and indicated management.

Adult↗
PubMed1981

Detrusor reflex contraction inhibited by anal stretch.

Anal stretch has been advocated as a method to overcome detrusor-sphincter dyssynergia. In evaluating candidates for this technique, it has been observed that in some cases the detrusor reflex and the external sphincter contraction is inhibited. The detrusor-sphincter unit then assumes a lower motor neuron pattern. This explains the need of the Valsalva and Credé maneuver that had been incorporated in the anal stretch technique to allow dyssynergic patients to void.

Adult↗
PubMed1978

Serum bactericidal action and activation of the classic and alternate complement pathways by Neisseria gonorrhoeae.

In order to more fully understand the host defense mechanisms against gonococcal infections, we decided to define the role of the classic and alternate complement pathways in gonococcal BA. Sera and infecting isolates were collected from several patients with genital and disseminated gonococcal infections. Sera from two never-infected subjects and a hypogammaglobulinemic patient were also collected. Sera from patients with genital gonorrhea and never-infected controls demonstrated marked BA for gonococci after 30 min incubation. Chelation of these sera with MgEGTA delayed the expression of BA. Consumption of C3, but not C4, was observed in chelated samples. BA could not be demonstrated in any of the sera from DGI patients or the patient with hypogammaglobulinemia. Aliquots of fresh and chelated hypogammaglobulinemic serum to which IgM or IgG antigonococcal antibodies were added showed marked BA by 30 and 60 min, respectively. Absorption of chelated serum with a serum-sensitive isolate eliminated the previously observed delayed BA. The findings suggest that gonococcal serum BA is primarily associated with activation of the classic complement pathway. Activation of the alternate pathway also occurs; however, its expression is delayed and appears to be antibody-dependent.

Adult↗
PubMedDate not supplied

Effects of biologically active tumour-promoting and non-promoting phorbol esters on in vitro growth of melanocytic cells.

Sapintoxin A (SAP A), a naturally occurring biologically active but non-promoting phorbol ester, acts as an effective in vitro mitogen for freshly derived human melanocytes. Seven days after addition of 50 nM SAP A there was a four to fivefold increase in melanocyte number over that observed in untreated control cultures comparable to that achieved with a 50 nM concentration of 12-0-tetradecanoylphorbol 13-acetate (TPA). The fluorescent stage 2 promoter sapintoxin D (SAP D) also supported the growth of these cells, with a 50 nM dose producing an increase in cell number comparable to that observed with 200 nM TPA. Similar results were obtained with an established, but non-tumorigenic, line of murine melanocytes. The same compounds exerted a potent anti-proliferative effect against transformed melanocyte lines of murine and human origin associated with morphological alterations and an increase in melanin production consistent with induced cytodifferentiation.

Cell Division↗
PubMedDate not supplied

Anticoagulation in continuous veno-venous haemofiltration.

The reasons for introduction of a heparin protocol are explained, with best practice principles of a protocol stated. The pharmacological properties of heparin are explained, and standardisation of monitoring procedures discussed. The responsibilities of the nurse in both laboratory and clinical monitoring of the effects of heparin are discussed. The use of an algorithm to alter heparin dosages against APPT results is justified.

Algorithms↗
PubMedDate not supplied

Advance directives, current legal and ethical issues.

The current legal position from which an advance directive operates is clarified. The practicalities of advance directives are considered and the issues concerning enalties explored. The patient's capacity to refuse treatment is discussed in relation to the issue of consent. Situations concerning cardio-pulmonary resuscitation, pregnancy and accident and emergency are explored.

Accidents↗