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G Bruggmoser

Publications and source records attributed to G Bruggmoser.

32 records · Page 2Linked to original sources
PubMed1986

[Radiotherapy of esophageal cancer--indications, methods and attainable results].

From 1965-1985, in the Department of Radiotherapy of the University Hospital of Freiburg 226 patients with esophageal carcinoma have been treated with primary radiotherapy at a sufficient tumor dose - 138 of them with curative and 66 patients with palliative intention. With curative irradiation the survival rates between 1 at 5 years were 28.6%, 14.1%, 8.2%, 5.8% and 3.5%. To palliative indication the 1 year survival rate was 10.4%, none of these patients reached the two years' limit. Apparently relevant prognostic factors are: length of history, overall state of health, histologic classification, tumor stage, state of clinical remission, localization of the tumor. Our findings were compared with observations between 1965 and 1985. This paper deals with the problems of pre- and post-therapeutic irradiation, in combination with chemotherapy. Indications for radiotherapy, definition of the target volume and the different techniques of radiation planning and performance are discussed, especially with reference to comparison of stimulator- and CT-assisted radiation planning. We demonstrate the possibilities of rotation therapy with an electronically controlled diaphragm device developed in our department.

Adenocarcinoma↗
PubMed1984

[Short-term irradiation of glioblastomas with high-dose single fractions].

Compared to surgery alone, postoperative radiotherapy leads with glioblastomas (grade IV gliomas) to a significant improvement of the therapeutic results. The prolongation of survival time, however, is to a large extent compensated by the therapy itself (it normally implicates hospitalisation). Therefore, we tested the efficiency of rapid course irradiation with high fractions. 70 patients were treated daily with individual fractions of 3.5 Gy, 4 to 6 fractions per week. The entire dose amounted to 31.5 to 38.5 Gy. The average survival time was 33.5 weeks corresponding to the survival time known from the combined surgical and radiotherapy treatment of glioblastomas. An effective increase in therapy-free survival time seems possible, especially when the entire focal dose does not exceed 35 Gy. It is remarkable that the patients with the maximum exposure did not have the longest survival times and rates. Living conditions for the patients were similar to those with conventional fractionation , or even better. Rapid course irradiation with high fractions and a limited total dose (35 Gy) presently is - apart from the accelerated superfractionation - a successful measure to prolong the therapy-free survival time for patients with grade IV gliomas.

Adolescent↗
PubMed1982

[Pulmonary radioreaction demonstrated by x-ray pictures (author's transl)].

X-ray radiographs of the thorax of 119 patients suffering from Morbus Hodgkin (period of therapy VI/1974-III/1979) which have been taken during radiotherapy and at routine follow up examinations have been analysed with regard to temporal progress and extent of the pulmonary radioreaction after standardised mantle-field irradiation with a 4-MeV linear accelerator, extended-field satellite technique and tumor doses of 40-46 Gy. After a characteristic latency period without radio-morphological reaction the patients on average showed 12 weeks after beginning of irradiation signs of a beginning pneumonitis (phase I), after 15 weeks a florid pneumonitis (phase IIa), and after 20 weeks a florid pneumonitis with beginning shrinkage (phase IIb). After 5-9 months (average level 34 weeks) the pulmonary radioreaction was complete after having reached a steady paramediastinal lung fibrosis (phase IV). Classifying the radioreaction into 3 degrees of gravity a light pneumonitis was found in 44%, a medium one in 29%, and a severe pneumonitis in 16% of the cases. For clinical use it is important to know that after beginning shrinkage new expansion of mediastinum and/or of peripheral parenchymal shadows cannot be radioreactions. Primarily these new changes have to be interpreted as recurrence.

Adolescent↗
PubMed1981

[Optimization of reproducibility of irradiation fields with particular reference to irregular fields (author's transl)].

Optimum reproducible planning is one of the aims of radiation therapy. Distribution of dosage can be calculated very accurately with the help of presently available planning facilities. It was the purpose of this study to find out how accurate the initial adjustment of the therapeutic device can be. For this purpose, 1806 control x-ray films were evaluated. The initial correction quota was about 27%. The second part of the study dealt with reproducibility of field adjustment. Series of x-ray films recording the course were prepared with verification films; the resulting field distributions were calculated on the basis of these films, and compared with the planned fields.

Computers↗
PubMed1980

5 years of operation experience with a 4 MeV linear accelerator in radiotherapy.

The results of our experience in operating a 4 MeV linear accelerator Clinac 4 from Varian in radiotherapy are reported, especially considering the 12-hours-per-day operation for more than the last 3 years. Frequency of defects of different parts is discussed. The downtime adds up to 6 days per year, service and repair costs amount of US $ 33,--per patient.

Costs and Cost Analysis↗
PubMed1980

[First report of experiences with interstitial radiation therapy of the prostatic carcinoma using 125-I-seeds: indication, practical performance and radioprotection (author's transl)].

The practical and organizing performance of interstitial radiation therapy with 125-I-seeds in prostatic carcinoma is reported. Precautions and measurements for radioprotection are emphasized. First evaluations of these measurements show that this therapeutical technique can be performed in complete accordance with the directive for radioprotection. The computer-assisted isodose-planning and the in-vivo-measurements in the rectum, urethra and bladder confirm the steep decrease of the dose outside the irradiated focal volume. Hence, inflammatory symptoms accompanying the therapy are markedly allayed in comparison with percutaneous radiation therapy, in spite of a higher tumor dose. Because of the extensive operation, attention must be paid to the strict observation of indication criteria.

Brachytherapy↗
PubMed1978

[Present state of the wide-field megavoltage radiotherapy of Hodgkin's disease. Fundamentals, performance, side effects (author's transl)].

Therapeutic results of Hodgkin's disease could be significantly improved by the introduction of megavoltage radiotherapy equipment and more profound knowledge about this disease. By this way, five year survival rates of 70% can be achieved for all stages and up to 100% for the early stages. The wide field technique enables the coverage of all lymph nodes with protection of non involved organs. Simultaneously, these improved technical conditions make optimal radiation planning necessary which demands numerous technical auxiliaries. Radiation type and radiation energy are important preconditions for the therapy; production and usage of shilding blocks are necessary for individual performance. The principle for optimal radiation dose distribution are measurements and calculations on the phantom which are now included in computer programs. Nevertheless, radiation of large volumes represent a high stress for the patient. Despite the improvement of the therapeutic results there are except the acute radiation side effects, also irreversible alterations. These can be analysed only after long time observations and has to be balanced with the therapeutic results. The knowledge of these side effects is very important for the radiologist. Beside that, the risk of induction of a second tumor has to be considered. The present possibilities of absolute control of this disease enables the overtreatment of lesions in the early stages. Therefore it has to be postulated to regard the present therapy concepts with attention and to consider the possible side effects.

Acute Disease↗
PubMedDate not supplied

Experimental thermoradiotherapy of human tumour xenografts in nude mice: design of the hyperthermia system.

An experimental thermoradiotherapy study was started in 1986. For this study a hyperthermia system was developed for the heating of human tumours xenotransplanted into nude mice. Our treatment device was a four-channel computer-controlled hyperthermia system. Temperature was monitored by microwave radiometry at 3 GHz. Specifications of the radiometer were first evaluated under reference conditions, then thermal dosimetry was studied using non-invasive measurement of the brightness temperature TOR. Hyperthermia treatments were simulated in phantom material with radiometric monitor values TR of 40 and 41. In conjunction with the parameters of brightness temperature TOR, surface temperature TO and water bolus temperature TW thermal modelling was performed. Finally, we studied the influence of a perfused phantom to the microwave thermometry.

Animals↗
PubMedDate not supplied

Experimental thermoradiotherapy of human tumour xenografts in nude mice; design of the hyperthermia system.

An experimental thermoradiotherapy study was started in 1986. For this study a hyperthermia system was developed for heating human tumours xenotransplanted into nude mice. The treatment device was a four-channel computer-controlled hyperthermia system. Temperature was monitored by microwave radiometry at 3 GHz. Specifications of the radiometer were evaluated first under reference conditions. Subsequently, thermal dosimetry was studied using non-invasive measurement of brightness temperature, TOR. Hyperthermia treatments were simulated in phantom material with radiometric monitor values, TR, of 40 and 41. In conjunction with the parameters of TOR, surface temperature, T0, and water bolus temperature, TW, thermal modelling was performed. Influence of a perfused phantom also was studied on microwave thermometry.

Animals↗