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Biomedical subjects

G Brunetti

Publications and source records attributed to G Brunetti.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Human coenurosis. Localization to the sternocleidomastoid muscle].

Coenurosis, a parasitic affection rarely observed in man, is due to the presence in the tissues of larval forms of Taenias that live in certain domestic or wild carnivorous animals during their adult stage. The disease was confirmed in a young Senegalese patient after surgical excision of a cyst from the lateral side of the neck. Pathological and epidemiological data suggest that the affection is due to Taenia serialis serialis.

Adolescent↗
PubMedDate not supplied

Heart health Hamilton-Wentworth survey: programming implications.

This telephone survey (n = 601) provided baseline data for the development and evaluation of cardiovascular disease (CVD) prevention programming in the City of Hamilton. Questions covered health history, awareness of CVD risk factors, hypertension control, smoking, dietary fat knowledge, physical activity, and preferred sources of health promotion information. Body mass index values over 25 kg/m2 were calculated for 55.2% of respondents (n = 439). Smoking and poor diet were the most frequently reported CVD risk factors. Lack of time was the main barrier to increased physical activity for nearly 54% of respondents. Print media (55%) and physicians (36%) were preferred sources of healthy eating information, while physical activity information was most likely to be sought from recreation centres (37%) and print media (34%). Smokers who wished to quit would consult a physician. In the City of Hamilton, CVD prevention programming should support healthy body weights through promotion of active lifestyles and healthy eating.

Cardiovascular Diseases↗
PubMedDate not supplied

Immunocytological and mineralogical study of bronchoalveolar lavage in a group of subjects exposed to asbestos.

Twenty-five subjects (24 males and 1 female, mean age 57.4 years) who have been exposed to asbestos underwent chest radiography, high resolution computed tomography (HRCT) of the chest, lung function tests and bronchoalveolar lavage (BAL) for evaluation of cell components (total cell count, percentages of macrophages, lymphocytes, neutrophil and eosinophil granulocytes and the lymphocyte subpopulations CD3+, CD4+, CD8+, CD19+ and HLADR+), soluble factors (IL-8, IL-10, IL-12 and MCP-1 in the supernatant) and concentration of asbestos fibre. The subjects were subdivided according to the degree of their exposure, to the concentration of asbestos fibres in the BAL and to chest X-ray findings using the I.L.O. classification (0/0pl, 0/1 and 1/0 and above). According to the exposure index, we showed statistically significant (p < 0.05) higher lymphocytes percentage in the BAL of subjects with moderate exposure and significantly higher levels of IL-10 (p < 0.05) in the supernatant of subjects showing an absence of asbestos fibres in their BAL. In the group of subjects with a 0/0 and 0/1 radiological profile, the cellular component of the BAL was characterised by a higher percentage of lymphocytes (p < 0.02), whereas a trend toward an increase in the number of neutrophils was noted in subjects with obvious pulmonary fibrosis. The percentage of neutrophils was inversely correlated with some parameters of respiratory function such as vital capacity (p = 0.03) and the partial pressure of oxygen (p = 0.05) in the blood. Investigating the cytokines in the supernatant of the BAL, we found a trend toward lower concentration of IL-10 in the group showing the worst radiological picture (I.L.O. > or = 1/0), and a statistically significant negative correlation between this cytokine and pO2 (p = 0.048). Concerning the other cytokines and chemokines studied (MCP-1, IL-8 and IL-12), no significant differences were found to be associated with the radiological profiles. There were, however, positive correlations between the concentration of IL-8 and the percentage of neutrophils (p = 0.038) and between the concentration of MCP-1 and the percentage of lymphocytes (p = 0.006). A negative relationship between the concentrations of IL-12 and IL-10 has been also observed (p = 0.028). This research allows us to hypothesise that IL-10 may have a pathogenetic role in the evolution of asbestosis.

Adult↗
PubMedDate not supplied

Interleukin-7 production by B lymphocytes affects the T cell-dependent osteoclast formation in an in vitro model derived from human periodontitis patients.

Periodontitis is characterized by irreversible destruction of alveolar bone and connective tissue attachment in the periodontium. We recently reported that T cells support the osteoclastogenesis by the overproduction of nuclear factor-kappa-B-ligand (RANKL) and Tumor Necrosis Factor-alpha (TNF-alpha) in an in vitro osteoclastogenesis model from periodontitis patients (Pp). It is known that IL-7 stimulates the production of osteoclastogenic factors by T cells and IL-6 potentiates IL-7 expression. Thus, we studied the involvement of IL-6 and IL-7 in the T cell regulation of osteoclast (OC) formation, in an in vitro osteoclastogenesis model from Pp. We demonstrated high levels of IL-7 in both the media collected from PBMC cultures of Pp and the sera of the same patients. We also demonstrated that freshly isolated B cells from PBMCs of Pp were the source of IL-7 in our model. B cells, in fact, overexpressed IL-7 at mRNA and protein levels, and this production was up-regulated by IL-6. Moreover, the OC formation decreased in the presence of anti-IL-6 and IL-7 functional antibodies in PBMC cultures from Pp. These data suggest that B cells could be responsible for the T cell-dependent osteoclastogenesis in periodontitis through the involvement of IL-6 and IL-7.

Adult↗
PubMedDate not supplied

[Work capacity, residual capacity and work tolerance times. A proposed measuring method].

A simple method for assessing the physical working capacity [in terms of maximal work capacity, loss of work capacity in diseased people, long-term work capacity (or critical power), endurance time] is proposed. The method consists in performing two "6 minutes workload" of different but known power and in measuring the corresponding heart rates and O2 uptakes at steady state. The effort was a "step-test" at different height of the step and rate of ascent and descent from it. The O2 uptake was measured either directly or indirectly from a nomogram (starting from the step height and the frequency of the up and down). The measured and estimated values of O2- uptake were very well correlated and this might be an indication for the method to be used in not equipped factory ambulatory or directly in workplaces. The maximal capacity to perform an effort was calculated on the basis of the linear regression between heart rate and O2-uptake, calculating the O2 maximal values (VO2MAX) from the predicted maximal heart rate (FMAX); analogously, the critical power was obtained by calculating the O2 critical values (VO2CRIT) from the predicted critical heart rate (FCRIT); the loss of work capacity is the difference between two maximal powers, the theoretical and the measured one. The endurance time was measured on the basis of the hypothesis of a linear regression between level of an effort and logarithm of the time to perform it. Finally, a few procedures to assess the actual work capacity in subjects with pulmonary or blood diseases are discussed; in these subjects the O2 transfer might be limited by ventilation disorders or by low content of haemoglobin.

Adult↗