Biomedical subjects

G Budziński

Publications and source records attributed to G Budziński.

7 recordsLinked to original sources

PubMed2003

Plasma adiponectin concentration before and after successful kidney transplantation.

BACKGROUND: Adiponectin, a protein secreted exclusively by adipocytes, is presumed to be involved in the pathogenesis of atherosclerosis and insulin resistance. An elevated plasma adiponectin concentration was found in ESRD patients on hemodialysis (HD). However, the role of kidneys in adiponectin biodegradation/elimination is unknown. Therefore, we assessed plasma adiponectin concentrations in ESRD patients before and after successful kidney transplantation. METHODS: Among 44 hemodialyzed patients (29 men, 15 women; mean age 39 +/- 11 years; mean body mass index [BMI] 23.6 +/- 3.5 kg/m(2); mean duration of HD treatment before kidney transplantation 27 +/- 26 months), plasma adiponectin concentrations and insulin resistance indices (HOMA-R) were measured twice: immediately before kidney transplantation (Tx) and 1-2 days before patient discharge from the hospital with stable kidney transplant function (mean serum creatinine level 191 +/- 105 micromol/L). The control group consisted of 22 normotensive healthy subjects (12 men, 10 women). RESULTS: Among uremic patients, before Tx, plasma adiponectin concentrations were significantly higher than in healthy subjects (20.8 +/- 8.3 vs 8.7 +/- 4.8 microg/mL; P <.001) After successful Tx, plasma adiponectin concentrations decreased significantly (20.8 +/- 8.3 vs 15.7 +/- 7.0 microg/mL before and after Tx, respectively; P <.001). Simultaneously, after successful kidney transplantation, an increase in HOMA-R was observed (1.01 +/- 0.61 vs 1.43 +/- 0.83; P =.002). However, changes in adiponectinemia did not significantly correlate with serum creatinine or HOMA-R. CONCLUSION: The kidneys seem to play an important role in adiponectin biodegradation and/or elimination.

Adiponectin↗

PubMed2003

Surgically treated early complications after kidney transplantation.

Early surgical complications after kidney transplantation (KTx) remain important clinical problems. The 35 patients in whom forty-six complications appeared within 1 month required surgical treatment. The causes were divided into four groups: bleeding and/or hematoma of the perigraft region (n = 22); urological complications (n = 9); simultaneous bleeding and/or hematoma and urological complications (n = 6); and others (n = 9). Among the 28 cases of hemorrhagic complication, the source of bleeding was not localized during the reoperation in 53.7% cases. Vascular anastomotic leakage was confirmed only in 7.1% of patients. The most common urological complications were stricture of (46.7% cases) and leakage at (26.7%) the vesicoureteral anastomosis. Within 3 months after KTx nephrectomy was performed in 27.5% of patients who had been previously operated for surgical complications compared to 4.6% patients without interventions. Among patients with a single reoperation the graft had to be removed in 20.0% compared with 44.4% for those with multiple reoperations. Localization of the bleeding source causing an early perigraft hematoma is not always possible. The most common early urological complication is a vesicoureteral stricture caused by edema. Surgical complications that appear within 1 month after KTx increase the risk of early graft loss.

Adolescent↗

PubMed1997

[Surgical treatment of different forms of renovascular hypertension].

24 patients with renovascular hypertension were operated from 1995 to 1997. Patients were divided into three groups: group I-atherosclerotic stricture of renal arteries with or without aorta stenosis (13), group II-fibromuscular dysplasia (8), group III-stricture of vascular anastomosis after renal transplantation (5). All patients were disqualified from PTA. Operations of reanastomosis of renal arteries to aorta or prosthesis and TEA dominated in group I, the operation of choice in groups II and III was plastic procedure with patch or venous graft. Authors conclude that surgical treatment of renovascular hypertension is an efficient method of treatment in case of disqualification from PTA and the way of reconstruction should be dependent on the reason of renovascular hypertension.

Anastomosis, Surgical↗

PubMed1997

[Primary retroperitoneal tumors--course, diagnosis and treatment results].

36 patients with primary retroperitoneal tumors (PRT) were studied. In 15 cases (41.7%) tumours were found incidentally. Ultrasound examination seems to be the golden standard for finding asymptomatic retroperitoneal neoplasms. High percentage of malignancy (72.2%-26 cases), mesenchymal texture of tumors and late detection of the disease caused by its occult clinical course are the frequent reasons of inoperability (11 patients-30.5%).

Diagnostic Imaging↗

PubMed1997

[Atypical recipient and longterm results of kidney transplantation].

In their study authors compared the results of renal transplantations in a group of 51 patients with relative contraindications to a remaining group of 413 patients. Congenital anomalies or previously performed operations of urinary tract, previous renal transplantations, laparotomies, peritoneal dialysis, extreme atherosclerosis of the aorta and iliac arteries were regarded as relative contraindications. Results of the treatment do not differ considerably in both groups of patients what confirms the necessity of renal transplantations in difficult recipients.

Contraindications↗

PubMed1997

[Inflammatory tumors of the colon--diagnostic and therapeutic problem in clinical materials].

38 patients with inflammatory tumours of the large bowel (ITLB) were studied, it is 2.4% of all patients operated in our department for the large bowel tumours. 28 patients (73.7%) underwent elective surgery, 10 (26.3%) had emergency operations. One-stage operations were performed in 26 cases (68.4%) and two-stages operations in 12 (31.6%). Permanent colostomies were performed in 4 patients (10.5%). Histological examination indicated chronic colitis in 19 cases (50.0%), mostly on divercular disease basis, Crohn's disease in 7 (18.4%), profound ulcerative colitis in 5 (13.1%), actinomycosis in 3 (7.9%) and typhlitis in 2 (5.3%).

Actinomycosis↗

PubMed1980

Effect of histamine in sinus node arrested with reserpine.

Histamine restored spontaneous activity in the isolated rabbit sinus node arrested with reserpine. This fact suggests that catecholamines are not the unique activators of adenylate cyclase required for cardiac pacemaking, and may be replaced by histamine.

Adenylyl Cyclases↗