PubMed Health⌕ Search

Biomedical subjects

G Bunjevacki

Publications and source records attributed to G Bunjevacki.

24 records · Page 2Linked to original sources
PubMedDate not supplied

[Molecular characteristics of the thalassemia syndrome and prenatal diagnosis in a high risk family].

The diagnosis of thalassaemia maior has been established in a 6 months old infant by screenig tests. The sick child and his parents were included in the study. Reverse dote blot and allelle-specific PCR confirmed that the mother was heterozygous for mutation in the first intone of beta-globin chain at position 110-beta-IVSI-110. By gap-PCR it was established that the father was heterozygous for haemoglobinopathy Lepore. The child was double heterozygous for both mutations. During the next pregnancy, in the 11th week, faetal DNA was extracted from chorion villous. Fetus was heterozygous for haemoglobinopathy Lepore and carried the same mutation as the father. The parents the accepted information that the second child will be a silent carrier of mutation.

Female↗
PubMedDate not supplied

[Major and minor congenital anomalies in children with Wilms' tumor].

Wilms's tumour is a paediatric tumour of hereditary origin in 40% of cases. In children with Wilms's tumour associated congenital anomalies are frequent, particularly congenital anomalies of the kidney and urogenital tract. Over the period from 1972 to 1987 the authors carried out a prospective study and systematically investigated congenital major and minor anomalies in 24 children with Wilms's tumour. They revealed the presence of aniridia, bilateral cataract and cryptorchidism in 1/24 children, mental retardation, small stigated congenital major and minor anomalies in 40 chidism in 1/40 children, mental retardation, small stature and a cystic kidney in 1/40, mental retardation in 3/40. A detailed investigation of minor anomalies confirmed the presence of 2 to 3 anomalies in all observed children. Cytogenetic investigation was performed in all children. Only in a child with aniridia Wilms's tumour a cytogenetic anomaly, 11p deletion, was found.

Child↗
PubMedDate not supplied

[Clinical manifestations of neuroblastoma in children and their effect on prognosis].

There are many prognostic factors in neuroblastoma. In this paper we analyzed the prognostic importance of some clinical factors like age, stage of disease, primary localization and neurological manifestations in children with neuroblastoma. We analyzed 58 children with neuroblastoma who were treated from 1970 to 1988 at the Haematology Department of Children's University Hospital in Belgrade. According to statistical evaluation presence of neurological manifestations and age were not important prognostic factors in children with neuroblastoma. Only primary localization of the tumour and stage of the disease had significant influence on prognosis.

Child↗
PubMedDate not supplied

[Congenital mesoblastic nephroma].

Four children with congenital mesoblastic nephroma were treated at the Children's University Hospital in Belgrade, between 1979 and 1990. In relation to the total number of children cured from renal tumours (44), diagnosis of congenital mesoblastic nephroma was confirmed in 9% of all cases with renal tumours. The age of all diagnosed patients was under one year. Three patients developed unilateral and one patient bilateral congenital mesoblastic nephroma. The authors also stress the importance of differential diagnosis between congenital mesoblastic nephroma and other renal tumours, since therapy and prognosis of these tumours are different. In a case of bilateral congenital mesoblastic nephroma that later relapsed with malignant alteration, it is questionable whether bilateral nephrectomy was the most appropriate treatment.

Female↗