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Biomedical subjects

G Buttermann

Publications and source records attributed to G Buttermann.

At least 19 recordsLinked to original sources
PubMed1991

Effect of motilin on gastric emptying in patients with diabetic gastroparesis.

OBJECTIVES: Because disturbances of gastric emptying are a serious complication in insulin-dependent diabetic subjects with regard to the maintenance of good metabolic control, we wanted to assess the effectiveness of motilin as a potential treatment for gastric emptying disturbances. RESEARCH DESIGN AND METHODS: The intestinal hormone motilin has been shown to accelerate gastric emptying in healthy subjects. Therefore, we examined the effect of intravenous motilin on gastric emptying of a 99mTc colloid-labeled semisolid test meal in 9 insulin-dependent diabetic patients with diabetic gastroparesis. All patients had a significantly delayed gastric emptying rate compared with a group of 11 healthy control subjects. RESULTS: During the infusion of motilin, gastric emptying was accelerated, and it was no longer significantly different from control values. CONCLUSIONS: These data demonstrate that motilin and related compounds such as erythromycin derivatives could be useful for the treatment of disturbed gastric emptying in diabetic subjects.

Adult↗
PubMed1988

[Dual-photon absorptiometry: a new method of determining bone mineral content. I. Basic principles].

Today dual-photon absorptiometry (DPA) is recommended as the best procedure for diagnosing osteoporosis at an early stage considering its low cost, low radiation exposure and reasonable reliability. Cortical (neck of femur) and trabecular (L 2-4) bone mass has been determined repeatedly with DPA using 153Gd (NOVO Lab 22 a) in 545 females and 112 males with no evidence of bone diseases. Measured "normal" (age- and sex-related average) values for bone mineral content (BMC) differed significantly (p less than 0.01) from those of US inhabitants determined by the same equipment, i.e., they were on average about 30% lower, but matched well with corresponding results from Belgium. BMC-area was found the most suitable parameter both for cross-sectional and longitudinal studies, since it is independent of height and weight. But there is still need to reduce the overlap and improve accuracy and reproducibility for making decisions after shorter intervals. Assessment of the individual mineral loss and fracture risk by comparison with average values remains problematical due to the wide range of "normal" BMC values, and in women additionally due to the variable onset of menopause. For estimations of the individual fracture risk of elderly patients BMC should not be normalized on age, because at the age of 65 half of the women had "pathologic" values, i.e. were below the so-called "osteoporosis threshold". Comparison of the individually measured postmenopausal BMC with average values of premenopausal women and with BMC values normalized to their menopausal age may be helpful approaches to overcoming these difficulties.(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗
PubMed1986

[Endoscopic intragastric detection of hydrogen].

The sensitivity of hydrogen (H2) breath-tests for testing small-intestinal bacterial overgrowth is limited by many factors. In this study H2 was tested directly with a selective electrochemical cell in a sample of stomach gas obtained during gastroscopy. This was possible in 100 of 109 cases. In patients with dyspeptic disorders (complaints of excess gas) H2 concentrations were significantly higher than in the group of patients without these complaints (p less than 0.001). In dyspepsia the stomach-test was significantly more often pathological than H2-breath-test with glucose (p = 0.01). There was no correlation between the results of both tests in 66 cases. Intragastral H2 may result from H2-reflux from the small bowel, because there was no difference in bacterial growth in gastric and duodenal juice and in gastric mucosa of patients with high and normal H2 concentrations in the stomach and because a motility disturbance of upper GI-tract (prolonged gastric emptying time) correlated well with H2-concentrations (p less than 0.05). PH of gastric contents, various ingested dietary substrates, smoking, endoscopic and histological diagnosis did not influence ig H2. Measurement of H2 during gastroscopy may give immediate evidence of small bowel motility-disorders.

Adult↗
PubMed1981

[Postoperative thromboembolism prophylaxis with a reduced low dose heparin fraction and dihydroergotamine in fixed combination (author's transl)].

In a prospective randomized study th efficacy and tolerance of the conventional low dose heparin regimen was compared with a new combination of dihydroergotamine (DHE) and a reduced proportion of heparin (Heparin-Dihydergot 2500) with regard to postoperative thromboembolism prophylaxis in 350 general surgical patients. The result showed that the new combination had the same thrombotic protective action as low dose heparin monotherapy, but with regard to the concomitant risk of hemorrhage it seemed a significantly superior prophylactic variant.

Abdomen↗
PubMed1978

Determination of total, divided and regional tubular clearance and excretion by compartmental analysis of camera renograms.

A method to analyze the camera renogram is described in a mathematical manner. It is based on a 6-compartment model, which simulates the hippurate in vivo kinetics. Results are transfer rate constants from which the tubular clearance (by multiplying with the plasma volume) and additionally excretory parameters can be derived. The method is quick and simple and needs a gamma-camera and a small data processing system only, but no special equipment and no blood sampling.

Computers↗
PubMed1978

Comparison of different methods of clearance determination.

Clearance determination by compartmental analysis of hippurate renograms was compared in 30 cases to the conventional PAH and to the partly shielded whole body counting technique. Good correlations between compartmental analysis and PAH method (r = 0.96) as well as the whole body technique (r = 0.94) were found. Correlation between PAH and whole body method was not always satisfactory (r = 0.85). In an additional study influence of greater count rates become obvious: correlation coefficients increase from 0.89 (131I-hippurate, n = 97) to 0.95 (123I-hippurate, n = 38). Determination of the divided clearance correlates well (r = 0.95). Using 123I-hippurate all the information available by radioisotopic kidney investigations can be obtained in a one-step procedure.

Aminohippuric Acids↗
PubMed1978

[Optimation of postoperative prophylaxis of thrombosis in gynaecology (author's transl)].

The prophylactic effect of heparin dihydroergotamine, the combination of these two (Heparin-Dihydergot) and acetylsalicylic-acid in the prevention of deep vein thrombosis was investigated in a prospective randomized clinical trial involving 454 patients. Evidence of thrombosis was detected by the 125I-fibrinogen-uptake-test in 22 out of 75 patients (29.3%) in the control group. The application of 2 x 0.5 mgDHE or 2 x 5000 IU of heparin reduced the incidence of deep vein thrombosis to 7%, which is statistically significant. After simultaneous prophylaxis with both drugs the incidence dropped to 2%. The combined use of DHE and heparin may be considered the best prophylactic regimen available for lowering postoperative DVT. After application of 3 x 0.5 g of ASS frequency of DVT decreased only to 15.3% and shows poor prophylactic efficacy.

Adult↗
PubMed1977

[Quantitative assessment of drug-induced prophylaxis of postoperative thromboembolism. Comparison of frequencies of deep vein thrombosis and pulmonary embolism using acetylsalicylic-acid, dextran, dihydroergotamine, low-dose heparin and the fixed combination of heparin and dihydroergotamine (author's transl)].

2136 patients in general surgery, gynaecology and urology were investigated by the 125I-fibrinogen-uptake-test for detection of postoperative deep vein thrombosis (DVT). They received at random one of low-dose heparin, dihydroergotamine, the fixed combination of both drugs (Heparin-Dihydergot), low molecular weight dextran and acetylsalicylic-acid (ASS). When DVT was detected repeated lung perfusion scintigraphies were carried out for diagnosis of embolic pulmonary perfusion defects. Results demonstrate the outstanding effect of Heparin-Dihydergot, which is not only 2-3 times better than the anti-thrombotic standard low-dose heparin but also eliminates almost completely the risk of postoperative embolism. The preventive efficacy of ASS and dextran must be considered to be poor and not comparable to that obtained when using heparin, dihydroergotamine or the combination. Now Heparin-Dihydergot is the new standard with which all prophylactic procedures should be compared.

Adult↗
PubMed1976

Prevention of postoperative thromboembolism by various treatments. Controlled clinical trial in 632 patients using 125I-fibrinogen uptake test and lung perfusion scans in patients with deep venous thrombosis.

In 632 patients efficacy of dihydroergotamine (DHE) in preventing postoperative deep venous thrombosis (DVT) and pulmonary embolism (PE) was tested vs. low-dose heparin (LDH) by means of the 125I-fibrinogen uptake test (RFUT). The incidence rate of DVT dropped from 36% (untreated group) to 17% after LDH, to 13% after DHE, and to 9% after simultaneous prophylaxis with both drugs. In patients with lower risk operations lasting not longer than 2 hs complete prevention of DVT was achieved by combined use of LDH and DHE. PE incidence in repeated lung perfusion scans of patients with positive RFUT was reduced to 4.3-2.6% (treated groups) in comparison to an incidence of 50% in the control group. This means the decrease of PE was overproportional in all treatment groups in comparison to the decrease of DVT incidence. The combined use of LDH and DHE may be considered as the best prophylactic regimen available for lowering postoperative DVT and PE.

Clinical Trials as Topic↗