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Biomedical subjects

G C Moore

Publications and source records attributed to G C Moore.

7 recordsLinked to original sources
PubMed1981

Pulmonary hemosiderosis and immune thrombocytopenia. Initial manifestations of collagen-vascular disease.

Severe iron deficiency anemia, pulmonary infiltrates, and cutaneous hemorrhage associated with thrombocytopenia developed in a 7-year-old girl. A typical clinical course and the presence of abundant hemosiderinladen macrophages in the gastric juice and alveoli suggested a diagnosis of idiopathic pulmonary hemosiderosis (PH). Investigation of the marked thrombocytopenia, not previously reported as a finding in IPH, resulted in the demonstration of antiplatelet antibody in the patient's serum and on her platelets. Response to corticosteroid administration and splenectomy was consistent with idiopathic thrombocytopenic purpura (ITP). The IPH and ITP may have occurred coincidentally in this patient, but certain pathophysiological similarities between these two disorders and ultimate development of a poorly defined fatal diffuse connective tissue disorder suggest that thrombocytopenia and intrapulmonary hemorrhage were related.

Anemia, Hypochromic↗
PubMed1980

Mesenchymal neoplasia and congenital pulmonary cysts.

A malignant mesenchymoma exhibiting a varied spectrum of differentiation developed within a congenital pulmonary cyst 6 1/2 years after the cyst was first recognized. Related tumors with a similar gross appearance have been previously described and have included rhabdomyosarcomas and so-called pulmonary blastomas. There is a low but distinct risk for the development of mesenchymal sarcomas within congenital peripheral pulmonary cysts.

Child↗
PubMed1976

Respiratory failure associated with familial depression of ventilatory response to hypoxia and hypercapnia.

Respiratory failure has been associated with depressed ventilatory responses to hypoxia or hypercapnia or both. The possibility that familial factors are responsible for decreased chemosensitivity prompted this study of a child with unexplained respiratory failure and normal lung function. We found his ventilatory response to hypoxia and hypercapnia to be virtually absent. Studies of six healthy immediate family members (parents and siblings) showed that hypoxic response, as measured by an index of the relation between ventilation and hypoxia (index A), was consistently reduced: 45 +/- 8.7 S.E.M. (normal, 127 +/- 8.7) (P less than 0.005). Response to hypercapnia, measured as the slope of the ventilatory response to hypercapnia, was lower than normal, averaging 0.95 +/- 0.16 liters per minute per millimeter of mercury (normal, 1.76 +/- 0.13) (P less than 0.01). The patient's respiratory failure seemed related to deficient ventilatory responses to hypoxia and hypercapnia. It seems likely that this depressed hypoxic response is of familial origin.

Adolescent↗