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Biomedical subjects

G C Mussa

Publications and source records attributed to G C Mussa.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Sentinel lymph node and breast cancer staging: final results of the Turin Multicenter Study.

AIM OF THE STUDY: Validation of the sentinel node (SN) technique in breast cancer by means of lymphoscintigraphy. MATERIALS AND METHODS: From December 1996 to January 1999 102 T1-T2 breast carcinoma cases were recruited in Turin. 99mTc-human serum albumin colloids were injected subdermally the day before surgery (mean activity, 5.2 +/- 2.5 MBq). Scintigraphic imaging was performed after injection. After identification of the SN during surgery by a hand-held gamma probe, the SN was excised and sent for histologic examination. SN histology was compared with that of other axillary nodes. RESULTS: The SN detection rate was 86.3%; among 88 cases with an identified SN, 37 (42%) had axillary metastases; the SN was metastatic in 35 cases (sensitivity, 94.6%); in 51.3% of pN+ cases (19/37) the SN was the only metastatic site. In two of the 53 negative SNs, SN histology did not match with that of the remaining axilla (negative predictive value, 96.2%; staging accuracy, 97.7%). CONCLUSIONS: Our results agree with those reported in the literature; however, except in clinical trials and experienced structures axillary lymph node dissection should not be abandoned when mandatory for prognostic purposes, considering that at present SN biopsy alone is not completely accurate for axillary staging, especially in the absence of an adequate learning period.

Adult↗
PubMedDate not supplied

Patients with Hashimoto's disease treated with L-thyroxine and followed for three years.

This study investigated the effectiveness of L-thyroxine management in 32 patients (mean age 11 years and 2 months; M:F = 1:5) with Hashimoto's disease followed annually for 3 years. One (8%) of the 12 patients, euthyroid at the onset, never required treatment; of the four (33%) who began treatment immediately, two were able to stop at the 1st or 2nd follow-up, whereas two had to continue. The other seven (59%) who did not begin treatment immediately had to start at the 1st, 2nd or 3rd follow-up. The findings in this small series suggest that hormone management may prove effective to a certain extent in euthyroid Hashimoto patients, primarily as a means of prevention.

Adolescent↗
PubMedDate not supplied

Factors at onset predictive of lasting remission in pediatric patients with Graves' disease followed for at least three years.

Seventeen pediatric patients (mean age at diagnosis 10 yr and 9 mo +/- 2 yr and 9 mo) with Graves' disease treated with 0.3-0.7 mg/kg/day methimazole and followed for at least three years, during which drug suspension was attempted on attainment of good clinical and metabolic compensation, were retrospectively studied to look for factors predictive of lasting remission present at onset. Lasting remission was defined as a clinical and laboratory picture of euthyroidism lasting at least one year in the absence of treatment at the end of the follow-up. A distinction was drawn between patients who reached remission after one or two courses (groups 1 and 2) and those who never attained a lasting remission (group 3). TRAb (TBIAb) levels at onset were the only factor significantly correlated with the response to treatment. Age at diagnosis, goiter size and fT3 and fT4 concentrations were not significantly correlated with the clinical picture. The series was too small to allow any assessment of the real importance of these factors, though a generally better response was displayed by children over 11 years old, without appreciable or with very small goiter and moderately increased thyroid hormone levels at onset (fT3 < 25 pg/ml in 10/10 in groups 1 and 2 and 2/7 in group 3 patients; fT4 < 40 pg/ml in 7/10 in groups 1 and 2 and 3/7 in group 3 patients). It was also found that better results were obtained when the initial drug course was protracted for at least two years.

Adolescent↗
PubMedDate not supplied

[Goiter in childhood].

In this review on goitre in pediatric age we will differentiate clinical conditions of euthyroidism, hypothyroidism or hyperthyroidism. From an etiopathogenetic point of view we are observing a decrease in endemic goitres due to a defective iodide intake with diet. More common are the defects in hormonal synthesis, genetically transmitted; the connections between immune system and thyroid diseases, e.g. Hashimoto thyroiditis and Grave's disease, are discussed. We will also deal with minor goitre conditions, such as the rare familial peripheral resistance to thyroid hormones.

Adolescent↗