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Biomedical subjects

G C Pant

Publications and source records attributed to G C Pant.

At least 19 recordsLinked to original sources
PubMed1990

Epidemiological correlates between consumption of Indian chewing tobacco and oral cancer.

The problem of cancer is universal; the only variation occurs in the type, site or other clinicoepidemiological parameters. Peculiarly enough, oral cancers caused by chewing tobacco are common in India and some parts of the Indian sub-continent. Oral cancers caused by other carcinogens are not common in these areas. The present study shows a significant association (P less than 0.001) between the use of Indian chewing tobacco and oral cancer. Number of quids, mean quantity of tobacco and mean duration of keeping the quids in the mouth had direct dose and effect relationships in causation of oral cancer. A dose of 10 gms of chewing tobacco for about 26 years was observed to have produced cancerous lesions in the buccal cavity.

Cheek↗
PubMed1990

Radiation therapy for symptomatic vertebral haemangioma.

Vertebral haemangiomas are slowly growing benign tumours and are usually asymptomatic. They rarely cause symptoms and signs related to cord compression. Larger lesions create significant problems during surgery because of haemorrhage and vascular supply crucial to spinal cord function. In such severely symptomatic vertebral haemangiomas, radiation therapy has been tried and good results obtained, especially in terms of good functional recovery. We have treated 17 patients (including nine paraplegic patients) with radiotherapy (Co-60). Treatment was given by single posterior field, encompassing the involved area with a dose of 35-40 Gy in 3 to 4 weeks (five fractions per week). All patients with pain and tenderness were relieved completely (87.5%) or partially (12.5%). Similarly patients with numbness and paresis showed either complete (66.7%) or partial response (33.3%) from symptoms on follow-up. Out of nine paraplegic patients six (66.6%) had recovered completely, one (11.2%) partially and two (22.2%) had no response. The two patients who did not show any marked relief, had paraplegia of longer duration (more than 6 months). Our study indicates that severely symptomatic vertebral haemangioma can be successfully treated by radiation therapy and it can be chosen as first line of treatment with an optimum dose of 35-40 Gy in 3 to 4 weeks.

Adolescent↗
PubMed1984

High-dose versus low-dose CMFP regimen in advanced breast cancer.

Fifty cases of advanced breast cancer (stages III and IV) were treated by combination chemotherapy. The study compares the two different dose schedules and toxicities of a combination of cyclophosphamide, methotrexate, 5-flurouracil, and prednisone. Results are better with high-dose regimen, though the incidence of toxicity is much as compared to low-dose schedules, but, considering the beneficial response, the high-dose schedule is recommended.

Administration, Oral↗
PubMed1981

A clinicopathological study of primary gastrointestinal lymphoma.

A retrospective analysis of 48 cases of histologically proven primary gastrointestinal lymphoma was done. The analysis covered a 12-year period from January 1966 through December 1977. Four percent of all malignant tumors of the gastrointestinal tract were of this type. Males outnumbered females by a ratio of 1.8:1. The mean age of the patients was 21 years. The vagueness and variability of clinical features and nonspecific radiological findings were the main reasons for subjecting all the patients in this series to laparotomy. The most common site of involvement was the ileocecal region, followed by the ileum, the jejunum, and the stomach. Most of the cases were in an advanced stage of the disease as was suggested by the finding of lump in 60% and ascites in 20% of the cases. Radical resection, possible in only six cases, appears to be the best treatment. The effectiveness of radiotherapy and chemotherapy were disappointing. Prognostically, cases of localized and polypoidal lesions of the small bowel and Hodgkin lymphoma showed better survival.

Adolescent↗
PubMed1981

Male breast cancer.

This study comprises 27 cases of male breast cancer treated at the University Hospital from 1966 through 1978. Its incidence was 0.53% of all cancer in males and 3.2% of all mammary cancers. Mean age was 52 years old. Lump in the breast was the commonest presenting feature in all patients followed by skin ulceration in 44.4% of cases. The average duration of symptoms was 16 months. Twenty-five patients had infiltrating duct carcinoma and two had papillary carcinoma. Two cases were in stage I, 10 in stage II, 11 in stage III, and 4 in stage IV. Of the 12 patients in stages I and II who underwent radical mastectomy, the axillary lymph nodes were pathologically negative in stage I and positive in stage II. The nodes were clinically involved in stages III and IV. Simple mastectomy followed by radiotherapy were used in stage III cancer and all patients in stage IV cancer had only biopsy and palliative chemotherapy. Bilateral orchidectomy followed by estrogen gave only marginal benefit in terms of survival and objective regression. Only four patients, two each in stages I and II, are alive and well for more than five years. These include two cases of papillary carcinoma. Poor prognosis in this series was exclusively determined by axillary lymph node involvement, although other factors such as shorter span of symptoms, younger age group, higher incidence of skin involvement, and invasive nature of carcinoma also appear to be significant.

Adult↗
PubMed1981

Carcinoma of breast associated with pregnancy and lactation.

Out of 840 cases of breast carcinoma seen over a period of ten years, 18 were found to be associated with pregnancy and lactation. According to the mode of onset and presentation of the disease, these patients were divided into four groups. The average age of these patients was 31.9 years old. Thirteen out of 18 patients presented in a very advanced stage of the disease. In a short period, involvement of liver was noticed in 8, brain in 3, and bones and lung in 2 each. The disease was bilaterally simultaneous in two patients. The acceleration of growth was noticed during second and third trimesters of pregnancy as well as during lactation. The termination of pregnancy in three patients did not alter the clinical course of the disease.

Adult↗
PubMed1981

Ewing's sarcoma: A combined approach in the management.

Twenty-seven histologically confirmed cases of localised Ewing's sarcoma were treated by two different regimes. Radiotherapy alone was used in 13 cases and a combination of chemotherapy and radiotherapy in 14. Single agent chemotherapy (cyclophosphamide) was given sequentially in nine patients and cyclophosphamide and actinomycin-D in five. There is a significant difference in the response to these different regimes. Only 69.2% of patients treated by radiotherapy alone were disease-free, for a median period of 10.4 months and metastases were noticed in 53.8% of cases. The disease-free survival in patients treated by combination therapy (radiotherapy and chemotherapy) was 18.4 months and metastases were seen in only 42.9%. However, no metastases were seen in patients who received cyclophosphamide and actinomycin-D, during a period of 14 months and only one patient showed residual disease. It is concluded that the addition of cyclophosphamide alone is not adequate in the management of Ewing's sarcoma. Actinomycin-D in addition to cyclophosphamide has improved the disease-free survival period significantly. The optimum dose of radiotherapy and its combination with other chemotherapeutic agents needs further trials to find the best and most suitable schedule.

Adolescent↗
PubMed1980

Extramedullary plasmacytoma: simulating a soft tissue sarcoma of the chest wall.

Extramedullary plasmacytoma occurs infrequently as compared to osseous myoloma. A single case of extramedullary plasmacytoma was seen during the last 10 years whose initial presentation was that of a soft tissue sarcoma of the chest wall. Clinical data along with relevent investigation and treatment results are discussed with a review of the literature.

Biopsy↗
PubMed1979

Radiation myelopathy.

Five cases of radiation myelopathy were found in a total of 10,000 cases given radiotherapy from 1968 to 1977. The clinical presentation and treatment details including the total dose, treatment volume, number of fractionations, overall time, and the RET value at the spinal cord were calculated and compared with other reports on this subject. The total number of fractionations ranged from 20 to 26 with an overall time of 32 days to 37 days. The dose received by four patients ranged from 1030 to 1900 RET, a little higher than the tolerance level of the spinal cord as compared to reported values. Two patients in this series had high blood pressure. The incidence of radiation myelopathy, already acceptably low, could possibly be reduced further by meticulous planning of radiation.

Carcinoma, Squamous Cell↗