PubMed Health⌕ Search

Biomedical subjects

G C Prasad

Publications and source records attributed to G C Prasad.

At least 19 recordsLinked to original sources
PubMed1997

Antitumor activity studies of newly synthesized N-salicyloyl-N'-(p-hydroxybenzthioyl)hydrazine and its copper(II) complex both in vivo and in vitro.

A new ligand N-salicyloyl-N'-(p-hydroxybenzthioyl) hydrazine (H2STPH) and its Cu(II) complex [Cu(SPTH)] were prepared and characterized by analytical and physicochemical studies. In vivo antitumor activity of [Cu(STPH)] has been tested against breast tumor in C3H/J strain mice and in vitro on P-815 (murine mastocytoma) and K-562 (human erythroleukemia) cells. LD50 values were estimated at a dose level of 100 mg/kg body weight and a light microscopic study also carried out.

Animals↗
PubMed1978

Biogenic amine response to whole body irradiation. Prevention by APTH.

60Co whole body irradiation with 154.8 mC/kg (600 R) resulted in a mortality of 50 per cent within two weeks. Administration of 1-acetyl-3-phenylamidine thiocarbamide hydrochloride (APTH) 30 min before irradiation prevented this mortality. Irradiation eliminated neurosecretory material from the perikaryons of the supraoptic and paraventricular neurons, whereas APTH counteracted this action. APTH also increased the synthesis of bioamines (5-hydroxytryptamine, catecholamine and acetylcholine).

Acetylcholine↗
PubMed1977

Serum electrophoretic pattern in osteoarticular tuberculosis.

A serum electrophoretic study was carried out in 37 established osteoarticular tuberculosis cases. The result of this study has been analysed according to severity and chronicity and also after treatment, including certain streptomycin-resistant cases. It has been observed that there was a decrease in albumin and an increase in Alpha2 and gamma-globulin fractions of serum protein as the disease became more advanced and chronic in nature. The administration of known antitubercular drugs reverses this phenomenon. The resistant cases revealed an increase in gamma-globulin fraction at almost the same level as observed in the untreated cases.

Adolescent↗