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Biomedical subjects

G C Serra

Publications and source records attributed to G C Serra.

At least 19 recordsLinked to original sources
PubMed2000

[Neuronal dysplasia of the colon. A case report].

A clinical case of Neuronal Intestinal Dysplasia (NID) is reported. This is an important pathology which is part of congenital alterations of bowel's innervation. This disease consists of two forms (A and B) which occur during different ages causing problems in intestinal motility with consequent various symptoms. Actually NID is diagnosed easier than in the past because histopathological techniques are very refined and permit to distinguish NID from cases once classified as Hirschsprung's disease. Histology can show an increase of Ach and Ldh activity in cholinergic fibers of lamina propria and of circular layer of intestinal wall. In this report a chronic status of constipation refractory to medical therapy has been treated with a total colectomy and an ileo-rectal anastomosis, resulting in a complete resolution of symptoms.

Abdominal Pain↗
PubMed1996

[Extrahepatic gastrinoma. Report of a clinical case].

Gastrinoma is a rare neoplasia producing gastrina, the hormone responsible of the clinic manifestations related to Zollinger-Ellison syndrome. The localization of gastrinoma is pancreatic or extrapancreatic (usually in Stabile and Passaro triangle). We present a case report concerning an extra-pancreatic gastrinoma not localized in this area and included in a lymph node. This is an extremely infrequent localization (2.4%). There are two different opinions about this localization. Some authors think that this is always a secondary lesion of a small primary neoplasia usually asymptomatic. Other authors think that there are primary lymph nodal gastrinomas that could be safely removed with excision of lymph node. The infrequent localisation of this case induced us to report this experience in order to contribute to the comprehension of this pathology.

Diagnosis, Differential↗
PubMed1993

[Refractory ascites: a fifteen-year experience with the peritoneovenous shunt].

The authors consider the various causes of ascites and they also develop the concept of refractory ascites. They consider the various possibilities of medical and dietary therapy whose failure constitutes the basis for a surgical approach. In the latter case it is being considered the Peritoneo Venous Shunt (PVS) that employs different types of valves. In the light of their personal experience, matured over a period of 15 years, in which 75 valves were positioned in 64 patients and precisely: 55 valves of Le Veen, 15 Hakim and 5 Denver, it is emphasized that the best results, as for as mortality and morbidity goes, were obtained through careful attention in the preoperative stage and during surgery itself with the privileged use of a Le Veen's valve. For such motives, since in a high percentage of these patients there persists a poor prognosis a year away from the onset of refractory ascites, a PVS seems proposable anyway and even though this will not alter the pathological outcome, there's a clear improvement in the quality of life without precluding any other surgical approach. Finally, the authors outline the possibilities offered by the Transjugular Intrahepatic Portosystemic Shunt (TIPS), as a new original approach for the resolution of refractory ascites.

Adult↗
PubMed1991

[Rhabdomyosarcoma. Presentation of a case with abdominal localization].

The Authors report a case of rhabdomyosarcoma observed in a 17-year-old boy. They emphasize that this rare form has an extremely rapid evolution, and in this case was also in an unusual site and of abnormal size. The difficulty of an early diagnosis and the impossibility of radical surgery are also underlined.

Abdomen↗
PubMed1990

[Carcinoma of the parathyroid glands. Apropos of a case associated with thyroid struma].

The paper reports a case of carcinoma of the parathyroid associated with thyroid struma and underlines the difficulties of intraoperative diagnosis and the surgical approach which should be adopted on the basis of this finding. Often the diagnosis of the malignant nature of the neoplasia is based on the possible appearance of local or distant recurrence rather than histological examination.

Adenoma↗
PubMed1990

[Insular carcinoma of the thyroid gland. Observation of a clinical case].

We present a case report about a patient affected by an "insular" thyroid carcinoma, a poorly differentiated carcinoma, situated morphologically and biologically in an intermediate position between the well-differentiated (papillary and follicular) and the totally undifferentiated thyroid tumors. We believe that its separation from other types of thyroid cancer will lead to a more accurate estimate of its prognosis and a more aggressive therapeutic approach.

Adenocarcinoma↗
PubMed1982

[Surgical treatment of endocrine tumors of the pancreas].

Following a brief review of the literature dealing with the rarity of this disease, and the diagnostic progress made to date, the surgical techniques applicable to the various locations of the neoplasia are described. Personal experience with 8 insuloma patients is reported.

Adenoma↗
PubMed1980

[Immune complex monitoring in Echinococcus infections].

In two patients with hepatic echinococcosis, we studied the in vivo interaction between circulating immune complexes and polymorphonuclear neutrophil surface receptors according to our previously described technique and quantitated the amount of circulating immune complexes by the C1q binding assay. Both tests were positive prior to surgical removal of the cysts, to gradually become negative to weeks later, and are persistently negative at two months after complete asportation. The application of the two tests may be of value in assessing surgical radicality and consequently the prompt disappearance of circulating parasite antigens. In particular, failure of these two tests two turn negative or the occurrence of further, new positivities may suggest either uncomplete eradication of the cyst or reinfection. These immunologic techniques appear to provide a better monitoring of echinococcosis than all the other well-known immunological tests which detect specific immunoglobulins present in serum for a long time and therefore unable to indicate the persistence or the new appearance of the parasite antigens.

Adult↗