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G C Sharma

Publications and source records attributed to G C Sharma.

At least 19 recordsLinked to original sources
PubMed2004

A computational solution of mathematical model for oxygen transport in peripheral nerve.

Time-dependent transport of oxygen in a peripheral nerve by simulating oxygen release, diffusion, chemical reactions and consumption in capillaries and surrounding peripheral nerve tissue using Krogh cylinder symmetry has been studied. Radial diffusion of oxygen is from a capillary to a surrounding cylinder tissue and axial diffusion to arterial distance to veins. A monoexponential or bioexponential function characterizes the approach of the oxygen tension to a new value. The time-dependent transport of oxygen in peripheral nerve with forward and backward reactions has been considered in this mathematical model which makes it different from earlier-studied models. A numerical technique has been used to find the solution.

Blood Flow Velocity↗
PubMed1996

A mathematical model for concentration of blood affecting erythrocyte sedimentation.

The rate at which red blood cells fall in vitro is used as a common clinical test for a number of pathological conditions. But this test becomes unreliable when one finds flaws in the model under consideration and these doubts raise the issue of aggregation of the red blood cells in concentration whose mathematical analysis is relatively unknown. However Huang et al. (Biorheology 8, 157-163, 1971) made some efforts and their model resembles certain moving boundary problems. In the present work the modifications to this model have been suggested so far as the concentration of the blood is concerned, it being one of the important factors to decide ESR (Erythrocyte Sedimentation Rate). In the equation for nutrient concentration, to be more realistic, we have taken account of transfer of nutrient to the tissue from the blood. The exact solution has been obtained using Laplace transform. A finite element technique has been suggested which provides results closer to that of the exact solution. Our results for the blood concentration may be useful for conducting the ESR tests. A special case for an emergent patient when nutrient concentration falls down considerably and glucose is provided to improve the condition, has been shown graphically.

Blood Glucose↗
PubMed1987

Effect of organic vehicles on the pharmacokinetics of aminophylline administered intravenously to goats.

Aminophylline dissolved in water, propylene glycol, or dimethyl sulfoxide was administered intravenously to goats in a randomized cross-over experiment. Model-dependent and model-independent pharmacokinetic parameters for theophylline were compared on the basis of the solvent used in the dosage form administered. No difference was found in any pharmacokinetic parameter. Thus, we found no evidence for the possibility that the organic solvents studied would confound pharmacokinetic investigations of theophylline and similar lipophilic drugs.

Aminophylline↗
PubMed1987

Disposition of fenbendazole in the goat.

The disposition of fenbendazole was studied in goats after oral or IV administration. Plasma concentration vs time profiles were determined for fenbendazole and all of its metabolites. The total excretion of the drug and its metabolites in urine and feces was also measured for 6 days. A biliary cannula was inserted in 1 goat to study the excretion of fenbendazole and its metabolites into the bile. Fenbendazole was converted to its sulfoxide (oxfendazole), and the sulfone, primary amine, and p-hydroxylated metabolites. The active metabolite, oxfendazole, appeared in plasma, but only trace amounts were found in feces or urine. The major excretory metabolite was p-hydroxyfenbendazole.

Administration, Oral↗
PubMed1980

Chest injury.

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Adolescent↗
PubMed1978

Isolation of antitumor polysaccharide fractions from Yucca glauca Nutt. (Lilliaceae).

An aqueous alcoholic extract of fresh flowers of Yucca glauca Nutt. showed striking antitumor activity against B16 melanoma in mice. Systematic fractionation of the extract by means of solvent extraction and gel permeation chromatography led to separation of two galactose containing polysaccharide fractions with marked inhibitory activity against B16 melanoma in mice. The extraction, fractionation, purification and preliminary characterization of the active polysaccharide fractions are described. The materials showed no activity against L1210 or P388 leukemias in mice. The implications of the findings for searches for both natural and synthetic anticancer agents are discussed.

Animals↗