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G C Ward

Publications and source records attributed to G C Ward.

4 recordsLinked to original sources

The protein-encoding gene T-urf13 is not edited in maize mitochondria.

RNA editing of T-urf13, a gene specific to the mitochondria of cytoplasmic male-sterile, type-T (cms-T) maize, and an adjacent, cotranscribed gene orf221, have been studied by cDNA sequencing. No editing was detected in 22 cDNA clones. This is the only report of a polypeptide-encoding gene in higher-plant mitochondria that is not edited. T-urf13 may not be edited because it is derived largely from the coding and flanking regions, which are rarely edited, of a ribosomal RNA gene. orf221 is edited; however, the similarity between the predicted amino acid sequences of orf221 in cms-T and normal cytoplasms is not increased.

Amino Acid Sequence

Legal standards of causation in chemical exposure litigation.

A discussion of the legal process that resolves disputes involving the questions of causation of exposure to chemical substances is presented. Toxicologists and pharmacologists called upon to testify in private litigation of whether or not exposure to a particular chemical caused an illness will have a clearer view of the law's notion of causation by the examples cited. The trends in the law on this subject are reviewed and ways are offered for scientists to influence future chemical exposure litigation.

Chemical Industry

Drug abuse in anesthesia training programs. A survey: 1970 through 1980.

Experience at our institution with drug dependence among anesthesia residents, coupled with a lack of published data, prompted us to survey US anesthesia training programs. Two hundred eighty-nine programs were surveyed, 247 (85.5%) responded, and 184 (74%) of these programs had at least one suspected incident of drug dependence to report. Three hundred thirty-four confirmed persons were reported, including a substantial number of instructors. Meperidine and fentanyl were the most frequently mentioned drugs. Behavior changes were frequently noted by staff personnel, and in general such changes led directly to detection. After confirmation of abuse, the majority of impaired anesthetists were referred for psychiatric care, with few in need of actual detoxification. Detailed follow-up was available for about 40% of the total; 71 persons were offered a return to their original place of employment, while 30 persons died of drug overdose. Chemical impairment may be more common than usually thought in anesthesia, perhaps in part because of drug availability.

Alcoholism

Nursing case study.

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Breast Neoplasms