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Biomedical subjects

G C Zografos

Publications and source records attributed to G C Zografos.

12 recordsLinked to original sources
PubMed1994

Adrenal adenocarcinoma: a review of 53 cases.

PROBLEM: Fifty-three patients (30 men, 23 women) with histologically proven adrenal carcinoma were reviewed. Nineteen (36%) had endocrine manifestations from functioning tumors. Arteriography was positive in 95% (19/20), CT scan in 94% (17/18), and ultrasound in 92% (12/13). Seventy-six percent of the patients, at the time of diagnosis, were stage III and IV. Most common metastatic sites were the liver, lymph nodes, bone, and lungs. Local recurrence developed in 39% of cases (15/38). METHOD: Forty-one patients underwent an operation. Complete surgical removal of all gross tumor was achieved in 24 patients. RESULT: The overall median survival time was 8 months, and the estimated 5-year survival rate 19%. There were significant differences in survival between the various stages (P = 0.01) and between the group of patients who underwent complete excision of the tumor and those with incomplete resection (P = 0.002). CONCLUSIONS: Complete surgical excision offers the best prospect for long-term survival in localized adrenal carcinoma.

Adrenal Cortex Neoplasms↗
PubMed1994

Regional chemotherapy in the canine liver.

Using a fluorometric assay, mean drug levels of Adriamycin were significantly higher in the normal canine liver following bolus injection of this drug via the hepatic artery or portal vein as compared to hepatic tissue levels following systemic intravenous administration (P < 0.001). However, the variations in tissue levels observed after hepatic artery (+/- 16.8 mcg/gm tissue) or portal vein (+/- 21.1 mcg/gm) infusion were significantly wider than those observed after systemic (+/- 1.3 mcg/gm) administration (P = 0.03). Using C14-labeled drugs, regional infusion of Adriamycin through the hepatic artery or portal vein resulted in significantly higher mean drug levels in the liver than after systemic intravenous administration, but the difference was more pronounced with bolus infusion of the drug than 1-hour infusion. 5-FU bolus or 1-hour infusion in the hepatic artery resulted in significantly higher mean drug levels in the liver compared to peripheral intravenous administration, but this was not so with the 3-hour infusion. The above experiments confirm previous studies that regional chemotherapy results in higher drug levels in the regional tissues compared to systemic administration. They also: (1) demonstrate the spotty drug distribution in the regional tissues after regional administration, a potentially correctable problem, and (2) suggest that the advantage of intra-arterial infusion may be more pronounced within a certain range of infusion times.

Animals↗
PubMed1994

Staging and grading in the survival of adrenal carcinomas.

In 53 patients with histologically proven adrenal cortical carcinomas the most common metastatic sites, at the time of diagnosis, were the liver, lymph nodes, bone and lungs, and during the course of the disease, the lungs. At the time of diagnosis six (11%) of our patients were in Stage S1, seven (13%) in S2, 11 (21%) in S3 and 29 (55%) in S4. Histologic grading (G) in 43 patients showed G1 grade in 11 (26%), G2 in seven (16%) and G3 in 25 patients (58%). Median survival in months (estimated 5-year survival rate) for the various stages were: S1 46 (33%), S2 84 (57%), S3 eight (18%) and S4 seven (7% at 2 years) (P = 0.01). Median survival in months (estimated 5-year survival rate) for the various grades were: G1 46 (46%), G2 24 (43%), G3 five (4% at 2 years) (P = 0.003). In this series, tumor stage (P = 0.01) and grade (P = 0.003) were predictors of survival and the two were closely correlated (P = 0.02).

Adrenal Cortex Neoplasms↗
PubMed1993

Desmoid tumors of the trunk and extremity.

BACKGROUND: Twenty-six patients with desmoid tumors of the extremities (n = 20) or trunk (n = 6) have been treated since 1977. Nine of these were referred with primary tumors and 17 with recurrent tumors. METHODS: The tumor was removed in all patients, and 10 received adjuvant radiation. Five patients (19%) developed local recurrence; one of them was lost to follow-up, and the remaining four patients had the recurrence controlled with surgical resection or resection plus adjuvant radiation. RESULTS: All 25 patients who have been followed are alive and disease-free at a mean follow-up of 84 months (median, 81 months). None with extremity tumors (n = 20) required an amputation. The estimated survival rate for the entire group is 95% at 42 months. CONCLUSIONS: Desmoid tumor of the trunk or extremities treated with surgical resection, supplemented selectively by adjuvant radiation, can be controlled locally in the majority (96%) of patients.

Abdominal Neoplasms↗
PubMed1992

Claviculectomy for the exposure and en bloc resection of adjacent tumors.

Claviculectomy has been described for primary or metastatic tumors of the clavicle. In 11 patients, claviculectomy was used as a technical expedient for the exposure and en bloc resection of large, underlying nodal metastases from melanoma (7 patients) and soft tissue tumors (4 patients). There were no wound complications. Three patients developed moderate edema of the arm. There was little limitation at the shoulder, and the use of the upper extremity has been essentially normal. Claviculectomy is well tolerated, provides good exposure of the underlying neurovascular structures, and, in some patients, provides a method of limb salvage for underlying tumors in preference to forequarter amputation.

Axilla↗
PubMed1992

Laser Doppler flowmetry in evaluation of cutaneous wound blood flow using various suturing techniques.

Measurements of blood flow on either sides of abdominal incisions and of uninjured control skin in 63 patients with three kinds of suturing techniques (clips in 21 patients, mattress in 21 patients, and subcuticular suture in 21 patients) on the 1st and 5th postoperative day were made, using an infrared laser Doppler flowmeter. There was a significantly higher flow on the 1st versus the 5th postoperative day. There is statistically higher blood flow in wounds sutured with subcuticular sutures in comparison with the two other groups. The method may allow the relationship of blood flow to wound healing to be evaluated.

Abdominal Muscles↗
PubMed1990

Evaluation of blood flow in human rectal tumours using a laser Doppler flowmeter.

A TSI laser Doppler flowmeter was used via a rigid sigmoidoscope in 20 consecutive patients with rectal carcinoma. Blood flow and velocity was evaluated at the tumour centre, tumour edge and adjacent normal mucosa; blood flow in the centre of the tumour was significantly higher than in normal mucosa (P = 0.05) and the tumour edge (P = 0.037). Two patients with ulcerated lesions had much lower blood flow in the centre of the ulcerative lesion.

Blood Flow Velocity↗