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Biomedical subjects

G Campus

Publications and source records attributed to G Campus.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Simple renal cysts, biochemical analysis of the cystic fluid, and comparison with blood parameters].

62 specimens of cystic fluid drawn back by ultrasound guided needle-aspiration in 37 males and 25 females were evaluated biochemical analysis including magnesium, calcium, phosphorus, chloride, uric acid, total protein, sugar, urea, creatinine, sodium, potassium, total cholesterol, AST, ALT, ALP, ACP, PAP, alpha-amilasys. In our study Cl, Na and sugar showed similar concentrations in the two fluids. Uric acid, and urea were more concentrated in the cystic fluid while Mg, Ca and total protein were more pronounced in the blood. The results obtained seem to indicate that simple renal cyst could originate from glomerular proximal tubulus part of the nephron as consequence of an obstructive cause.

Female↗
PubMed1991

[Clinical observations about an oligomineral water from the "Funtana Piscamu" of San Leonardo di Siete Fuentes].

In this study we evaluated the effects induced by the administration of a natural oligomineral water "Funtana Piscamo" di San Leonardo di Siete Fuentes on patient with urinary stone disease. Urine from 30 stone formers attending our metabolic stone clinic were compared with freshly voided urine of 20 normal volunteers. A marked increase in urinary magnesium (p less than 0.001) and a change in the urinary Ca/Mg ratio (p less than 0.005) were the most striking features disclosed in patients with stone disease. This natural oligomineral water drawn from "Funtana Piscamu di San Leonardo di Siete Fuentes" seems to have a long-term efficacy in urinary stone prevention.

Adult↗
PubMed1991

Evaluation of efficacy and tolerability of Nilutamide and Buserelin in the treatment of advanced prostate cancer.

Several different medical strategies have been proposed for the treatment of advanced prostatic cancer: androgen withdrawal by surgical castration on indirect suppression of androgen production by estrogen or estrogen-like substances, antiandrogen compounds or LH-RH analogues. The Authors evaluated in detail tolerability and efficacy of a combination therapy of a LHRH analogue (Buserelin) and a pure antiandrogen (Nilutamide) in a group of 15 patients with advanced prostate cancer (stage D) followed over a period of six months.

Aged↗
PubMed1990

[Qualitative analysis of 1447 patients with urinary calculi in the period 1979-1989 in Sardinia].

In this work we have examined the results obtained from the chemical analysis of 1447 urinary stones. The data concerning the frequency are distinguished according to the sex. Then we examined the difference between frequency of pure and mixed calculi in a sample, analyzing the results obtained by a subdivision in two periods of five years each. Our data are compared with those obtained in other regions of our country.

Female↗
PubMed1988

The effect of flutamide on basal and ACTH-stimulated plasma levels of adrenal androgens in patients with advanced prostate cancer.

The effect of flutamide on basal and ACTH-stimulated plasma levels of adrenal androgens was investigated in 6 patients with untreated advanced prostate cancer, aged 52-75 yr. Flutamide was administered (250 mg three times daily) for 10 days; before and after treatment, a synthetic ACTH1-24 stimulation test (250 micrograms im, with blood sampling immediately before and 60 min after the stimulus) was performed. Basal plasma 17OH-pregnenolone (delta 5-17OHP), 170H-progesterone (delta 4-17OHP), androstenedione (A), dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) were unchanged by flutamide treatment. In contrast, basal plasma testosterone (T) concentrations significantly increased (p less than 0.05). The response of cortisol delta 4-17OHP, delta 5-17OHP, A and DHEA to ACTH, as well as the ACTH-stimulated delta 5-17OHP/delta 4-17OHP, delta 5-17OHP/DHEA, delta 4-17OHP/A and DHEA/A ratios, were unchanged by flutamide treatment. These findings indicate that: a) Short-term flutamide administration enhances testicular steroidogenesis, via augmented LH pulse frequency; b) Adrenal steroidogenesis seems to be not affected by the drug, since ACTH-stimulated plasma levels of adrenal androgens and precursors/products ratios were unchanged.

Adrenal Glands↗
PubMed1988

Short term effects of flutamide administration on hypothalamic-pituitary-testicular axis in man.

The effect of short term administration of flutamide on the hypothalamic-pituitary-gonadal axis was studied in six patients with advanced prostate cancer (C2 stage). Flutamide significantly increased LH pulse frequency in all patients (p less than 0.05 by Wilcoxon's test). The FSH pulse analysis disclosed a similar pattern of LH. Plasma IC-T clearly increased following flutamide therapy; mean IC-T values were 2.67 +/- 0.47 ng./ml. and 4.67 +/- 0.62 ng./ml. before and after flutamide administration, respectively (p less than 0.05 by paired Student's t test). Our study demonstrates that flutamide acts in humans as a selective and specific antiandrogen compound.

Aged↗
PubMed1985

Long-term results of surgical treatment for redundant roots of the cauda equina.

Seven patients with redundant roots of the cauda equina were followed 2 1/2-10 years after surgical decompression. Improvement of signs and symptoms occurred in all patients. However, none of them was neurologically intact at the time of the last physical examination, although persistence of minimal neurological signs and/or occasional pain did not prevent a useful occupational activity.

Adult↗
PubMed1984

3H-leucine incorporation into subcellular fractions of human brain tumors.

In vitro incorporation of 3H-leucine into proteins of subcellular fractions of brain tumors has been investigated. Protein-bound radioactivity of nuclei and soluble fraction significantly increased compared to values of the normal brain. Moreover, the study demonstrated that microsomes, the most active fraction in protein synthesis in the normal tissue, always showed lower values than neoplastic nuclei. The pattern of 3H-leucine subcellular uptake obtained in brain tumors might suggest some similarities to that seen in the early phases of brain maturation.

Astrocytoma↗
PubMed1983

Omental transposition or transplantation to the brain and superficial temporal artery--middle cerebral artery anastomosis in preventing experimental cerebral ischaemia.

Transposition of lengthened omentum to the brain surface, transplantation of an omental graft, or superficial temporal artery--middle cerebral artery anastomosis were performed in dogs prior to transcranial occlusion of the ipsilateral middle cerebral artery at its origin, including the bifurcation of the internal carotid artery. Both omentum and by-pass were able to reduce the changes in cerebral blood flow, somatosensory evoked responses, cerebral water and electrolyte content, consequent to the ischaemic insult. In the experimental conditions adopted in this study, the effect of omental transposition in maintaining high levels of flow throughout the entire occluded hemisphere was more marked compared to that resulting from the other methods, while the onset of ischaemic cerebral oedema was affected approximately at the same degree by all procedures. The results point to the role of the transposed omentum in providing an effective collateral circulation to the ischaemic brain.

Animals↗
PubMed1982

Breast reconstruction with dermofat flaps after subcutaneous mastectomy.

Several techniques have been proposed for reconstruction of the breast after mastectomy. The authors present their experience with 19 patients; dermofat flaps were the preferred procedure. The authors discuss their technique of preparing and modeling the flaps, as well as some modifications and the possibility of using silicone prostheses. The limitations of the technique are reduced dimensions of the reconstructed breast, large and sometimes evident scars, and the difficulty or impossibility of performing the procedure on thin patients. The results are deemed positive, and the incidence of complications low. The authors consider the method a valid alternative to the use of prostheses in reconstruction after subcutaneous mastectomy.

Breast↗
PubMedDate not supplied

Socio-economic and behavioural factors related to caries in twelve-year-old Sardinian children.

Our aim was to describe socio-economic and behavioural factors related to caries experience in school children in Sassari, Sardinia (Italy). Four hundred and three 12-year-old schoolchildren were randomly selected and their teeth clinically examined after air drying, under standard light using a plain mirror and WHO community periodontal index for treatment needs (CPITN) ballpoint probe. The clinical DMFS index was recorded following a diagnostic threshold, CPITN following the WHO indications. A questionnaire concerning oral hygiene habits (OHH), the onset of toothbrushing habits (OTH), frequency of dental check-ups (DCU), sweet food and soft drink consumption and socio-economic background factors, i.e. parents' occupational status (SOCFAM) and parents' age, was filled in by children and parent(s)/guardian(s). The caries prevalence was 61.6%. A positive skewness of DMFS was observed. Regarding caries, a significant linear trend (p<0.05) was found among odds ratios at each exposure level in SOCFAM, OHH, OTH and CPITN. A logistic regression model for caries was constructed using related factors. CPITN (gingival conditions) gave a significant contribution in the predictive model (p = 0.01). Gender acted as an effect modifier on CPITN, so logistic regression models were constructed for males and females separately. CPITN was the only statistically significant covariate in males and OHH the only one in females. Our results confirm a high caries prevalence and also a need for preventive and educational programmes for caries in Sardinia.

Age Factors↗
PubMedDate not supplied

[Antibiotic prophylaxis with netilmicin in patients undergoing cystoscopic study].

Thirty adults of either sex, in several cases affected by severe urinary pathology, underwent check cystoscopy. An intramuscular injection of netilmicin 200 mg was administered one hour before the diagnostic procedure as antibiotic prophylaxis. Treated patients were controlled up to three months after cystoscopy, in order to verify the presence of urinary infections. Data obtained proved the efficacy of netilmicin in preventing postcystoscopy urinary infections in 87% of the cases. Safety was very good in all patients.

Adult↗