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Biomedical subjects

G Canale

Publications and source records attributed to G Canale.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Modification of vestibular function after radiation therapy for head and neck tumors].

The effect of radiation on the vestibular apparatus of animals and man have not been widely investigate. Referred symptoms are disequilibrium and spontaneous nystagmus in animals while histological features are intralabyrinthic haemorrhage, edema of the endolymphatic spaces and alterations of sensory hair cells. A group of 20 patients with head and neck cancer located in different sites (nasal cavity, oropharynx, oral cavity, parotid gland) underwent to vestibular investigations before and 3-6 months after radiation therapy. Ten patients (50%) showed an alteration of the vestibular function of peripheral origin after radiation treatment. Complications appeared from a few weeks up to several months following termination of radiotherapy. The slow development of the lesion permitted central compensation. Few patients had symptoms and vestibular symptomatology was always of secondary importance with respect to the initial pathology.

Adult↗
PubMedDate not supplied

[Relations between pure-tone audiometry and cortical evoked auditory potentials].

Slow vertex response (SVR) audiometry is presently one of the methods of choice in objective auditory threshold assessment. The aim of this study was to evaluate, as objectively possible, the relationship existing between the thresholds of SVR and or pure tone audiometry (PTA). The study was carried out on twenty subjects with hearing losses of various degrees and types. While mean differences between SVR and PTA thresholds ranged between 6 to 13 dB, in some cases values over 30 dB were found. No statistically significant intra- and interindividual discrepancies were found, even though in some cases the thresholds were given different in evaluations by different examiners. No statistically significant difference in SVR versus PTA thresholds was found in patients with sensory-neural and conductive hearing loss, while in subjects with normal hearing the difference between the thresholds was greater. Our results suggest that SVR is a reliable technique in objective threshold evaluation but that in single cases its threshold cannot be directly compared to that of pure tone audiometry.

Audiometry, Pure-Tone↗
PubMedDate not supplied

[Modified Semont's maneuver in the treatment of benign paroxysmal positional vertigo].

Benign paroxysmal positional vertigo (BPPV) is one of the most frequent causes of vertigo. It is characterized by a peripheral balance impairment which occurs during specific movements or positions of the head. The etiology of BPPV is not clear although recent studies by Harada have given more weight to the otolithic theory. The present author has found frequent otoconia attached to the dark cell area around the crista of the semicircular canals. The treatment of BPPV is based on functional re-education of the patient (Semont maneuvers, the Brandt Daroff technique, Norre's V.H.T). The present study involves 62 patients affected by BPPV. The Hallpike maneuver was employed to define the affected side and then the modified Semont maneuver was performed. Recovery was obtained in all patients. The cure rate proved to be 82% after the first examination. The modified Semont maneuver is easier to perform than the traditional maneuver and has given excellent therapeutic results.

Adolescent↗
PubMedDate not supplied

[Ewing's sarcoma in preschool children. Description of 6 cases].

Ewing's sarcoma (ES) is rarely diagnosed in the pre-school age; these few cases however present a number of difficult diagnostic and therapeutic problems. The Authors describe a series of six such cases aged less than 4 years diagnosed in the period 1974-1987. Standard treatment was modified with the purpose to reduce acute toxicity and late sequelae. These modifications are described in details. Four/6 patients are presently alive disease-free from 29 to 87 months from diagnosis (median, 34 months). Two patients died from acute toxicity. The Authors suggest that young children with ES may be treated successfully with proper adjustments of current protocols. Increased aggressiveness of chemotherapy regimens may compensate for reduced radiotherapy; however, the high susceptibility to infection of youngsters has to be taken into account and makes mandatory a careful monitoring during phases of profound myelodepression.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

[2 cases of osteomyelitis in acute leukemia in the induction phase of treatment].

Whereas children with Acute Leukemia are highly susceptible to infectious complications, the occurrence of acute osteomyelitis is extremely rare in these patients. The authors describe two such cases in children at onset of an acute lymphoblastic and of a myelomonocytic leukemia, respectively. In the former case, the clinical course has been characterized by the progressive involvement of several joints and bones. A citrobacter Freundii was isolated in the synovial fluid of an involved knee. This complication was successfully treated with proper antimicrobic agents and surgical toilet, while the patient was vigorously treated for her leukemia, achieving a complete remission. The latter case developed a right humerus osteomyelitis from an Enterobacter. The patient failed to respond to antibiotics, and his leukemia also turned refractory to antiblastic therapy. The difficulty in the differential diagnosis among the X-graphic aspects of leukemic, inflammatory and degenerative disease of bones are discussed by the authors. Some pathogenetic hypothesis of leukemic osteomyelitis are also presented.

Acute Disease↗