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G Canepari

Publications and source records attributed to G Canepari.

6 recordsLinked to original sources
PubMedDate not supplied

[Steroids, interferon-alpha and ribavirin treatment of cryoglobulinemic glomerulonephritis concurrent with HCV infection].

The treatment of mixed cryoglobulinemia concurrent with HCV infection is still under debate. We report the case of a patient referred to our unit for a membranoproliferative glomerulonephritis associated with HCV infection. A nephrotic syndrome and a slight reduction of glomerular filtration rate were present. We treated him with alpha-interferon for six months and prednisone for two months. We achieved a remission of the nephrotic syndrome without any significant reduction of the viral load. One year after the therapy had been suspended, the nephrotic syndrome relapsed and subsequently responded to a combined treatment with interferon ribavirin and prednisone. HCV-RNA became suddenly and persistently negative.

Adult↗
PubMedDate not supplied

[Continuous renal replacement therapies (CRRT)].

Several techniques are currently available in the continuous renal replacement therapy (CRRT) spectrum, adhering to different clinical conditions and illness severity. Commercially available machines have become more user-friendly, even for non-dialysis staff however, nephrologists need specific knowledge to give an adequate prescription that must be different from chronic hemodialysis. Competence and experience in the technical possibilities of CRRT lead to an individual ultra-filtration and treatment dose prescription. Clearances of solutes with different molecular weight can be modulated by coupling (combining) diffusion and convection, and by changing the fluid infusion rate. In addition, CRRT has an important impact on metabolism with its cooling effect, removal of nourishing substances and modification of electrolytic and acid-base balance. In septic patients standard CRRT has no specific indications in the absence of acute renal failure. Other extracorporeal therapies, such as high volume hemofiltration coupled with plasma filtration-adsorption (CPFA), have been developed aiming for a major influence on sepsis evolution. The versatility of CRRT has great value not only in adapting the treatment schedule to clinical conditions, but also in performing extracorporeal therapies in a wide array of logistical circumstances.

Acute Kidney Injury↗