Biomedical subjects

G Cannizzaro

Publications and source records attributed to G Cannizzaro.

At least 37 records · Page 2Linked to original sources

PubMed1986

Effect of single and repeated treatment of chlordiazepoxide and sodium valproate on water intake in the rat and their influence on the antidipsogenic action of naloxone.

The action of single and repeated treatment with chlordiazepoxide (CDP) (5-10 mg/kg i.p.) and sodium valproate (VPA) (100-200 mg/kg i.p.) on water intake of rats adapted to a daily 23-h water deprivation schedule was investigated. The influence exerted by single or repeated treatment of the two drugs on the antidipsogenic effect of naloxone (Nx) (1 mg/kg s.c.) was studied too. Our results show that with single treatment of CDP the dipsogenic effect is lower and not further modified by increasing dose and by the time-course of the session; with repeated treatment the dipsogenic effect is greater and further enhanced by increasing dose and by the time-course of the session. Single or repeated treatment with VPA does not significantly affect the water intake. Single treatment of CDP enhances the antidipsogenic effect of Nx, while CDP, after repeated treatment, reverses the antidipsogenic effect of Nx. With VPA-Nx association, the response is univocal (antidipsogenic effect) independent of the experimental conditions. The results are briefly discussed.

Animals↗

PubMed1985

Results of treatment with sodium sulbenicillin in thirty elderly patients with acute bronchopulmonary infection.

Thirty elderly patients with acute bronchopulmonary infections were treated with intravenous sodium sulbenicillin for up to 20 days at a dose of 4-6 g/day. Clinical results were excellent in 19 cases and good in 10 cases. In one case treatment had to be discontinued due to a dermal side-effect. It is concluded that sulbenicillin is a useful therapy for acute bronchopulmonary infections in the elderly.

Aged↗

PubMed1983

Antidipsogenic action of naloxone under different water deprivation conditions.

Naloxone (1 mg/Kg s.c.), in the light phase of the daily light-dark cycles during the 30 and 60 min of the test, shows an antidipsogenic effect of the same intensity in chronically water-deprived rats which drink more (+ 176% and + 162%) than the acutely water-deprived animals. In chronically water-deprived rats, the time interval from the drug introduction (5, 30, 60 and 90 min) is not critical for the intensity of the antidipsogenic action of naloxone. When water intake is controlled by a 20% variable ratio schedule that does not allow the animals to satisfy, during the session, more than 50% of their thirst, the time interval from the introduction of naloxone is critical. When the rats can drink freely for 30 min in their home-cage after they satisfied their thirst partially by means of bar-pressing, naloxone, paradoxically shows a weaker and not significant antidipsogenic action. The results and the usefulness of the behavioural test are briefly discussed.

Animals↗

PubMed1982

Further assessment of benzodiazepine-tricyclic antidepressant interaction. Effectiveness of combined treatment with ketazolam-nortriptyline on conflict behaviour in rats.

Using Geller and Seifter's conflict behaviour test, ketazolam in rat increases the rate of responses emitted both with and without punishment. Nortriptyline decrease the non-punished component of the schedule without influencing the punished one. With combined treatment, nortriptyline does not modify the effects of ketazolam on punished responses while nortriptyline, 1 h after administration, decreases, though not significantly, the facilitating action of ketazolam. After 24 h it significantly increases the depressant action of this benzodiazepine. The results suggest that with the combination tricyclic anti-depressant-benzodiazepine, as with these two categories of drugs, there is not always an increase in disinhibiting action, while depressant action has characteristics closely dependent on the properties of the benzodiazepine used.

Animals↗

PubMed1977

Influence of the suspension of continued treatment with flurazepam and amobarbital on two discrimination learning schedules.

The authors have studied the effect of the suspension of chronic treatment with flurazepam and amobarbital on the operant behavior of rats that for the first time were in the presence of two fixed-interval discrimination schedules. With the sound discrimination schedule, the responses emitted by the treated animals had charactistics similar to those of control animals. With the temporal discrimination schedule, though it is not possible to distinguish between learning rates, modifications in the intensity of the effect (increases in lever pressing) indicate that, considering the doses, the action of flurazepam is slight and that of amobarbital clear and statistically significant.

Acoustic Stimulation↗

PubMed1973