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Biomedical subjects

G Carenini

Publications and source records attributed to G Carenini.

At least 19 recordsLinked to original sources

Designing computer-based frameworks that facilitate doctor--patient collaboration.

A current trend in medicine involves establishing collaborative problem solving between patients and physicians in order to involve patients more in their own care. Neither diagnosis nor therapy can be completely successful unless the patient and the doctor understand each other and collaborate with each other in an effort to gauge the other's requests, needs and concerns. This is made even more difficult by the fact that there is often a big difference between the doctors and patients in terms of expectations, vocabulary used, and other factors. For diagnosis of many disorders, a detailed description of the problem and of the patient's history are required. For therapy, patients must understand how and when to take prescribed drugs, what changes to make in diet, exercise, or lifestyle and why they are important. This paper describes a model of asynchronous collaboration between people with very different knowledge of medicine in which a computer framework attempts to mediate between patients and physicians and reduce some of the differences in communication. It allows patients to pace themselves in familiarizing themselves with the relevant domain terms, some of the medical factors underlying the conditions under question, and the justifications and implications of the prescribed treatment plan. It also allows physicians to request more information of patients and gives patients contextual information to help them understand the underlying reasons for the questions. This framework has been partially implemented in the domain of migraines. As described in the paper, not only is the system designed to cooperate with the patient, but using the system also results in better mutual understanding between the doctor and the patient, thus leading to better collaboration between them.

Artificial Intelligence↗

An intelligent interactive system for delivering individualized information to patients.

This paper is a report on the first phase of a long-term, interdisciplinary project whose goal is to increase the overall effectiveness of physicians' time, and thus the quality of health care, by improving the information exchange between physicians and patients in clinical settings. We are focusing on patients with long-term and chronic conditions, initially on migraine patients, who require periodic interaction with their physicians for effective management of their condition. We are using medical informatics to focus on the information needs of patients, as well as of physicians, and to address problems of information exchange. This requires understanding patients' concerns to design an appropriate system, and using state-of-the-art artificial intelligence techniques to build an interactive explanation system. In contrast to many other knowledge-based systems, our system's design is based on empirical data on actual information needs. We used ethnographic techniques to observe explanations actually given in clinic settings, and to conduct interviews with migraine sufferers and physicians. Our system has an extensive knowledge base that contains both general medical terminology and specific knowledge about migraine, such as common trigger factors and symptoms of migraine, the common therapies, and the most common effects and side effects of those therapies. The system consists of two main components: (a) an interactive history-taking module that collects information from patients prior to each visit, builds a patient model, and summarizes the patients' status for their physicians; and (b) an intelligent explanation module that produces an interactive information sheet containing explanations in everyday language that are tailored to individual patients, and responds intelligently to follow-up questions about topics covered in the information sheet.

Anthropology, Cultural↗

Generating patient-specific interactive natural language explanations.

Patient compliance is a significant problem and is strongly correlated with the patients' understanding of their condition and prescribed treatment. Since doctors typically do not have large amounts of time to educate patients, and impersonal, voluminous patient handouts are largely ineffective, we propose the use of a sophisticated computer-based information system to generate tailored, interactive handouts to communicate with patients. Our system uses text planning and user modeling techniques to generate natural language descriptions of migraine, its symptoms, triggering factors and prescriptions. The system is capable of handling follow-up questions requesting further information, and generating responses in the context of previously supplied information--a capability unavailable in previous patient information systems. The system tailors its interaction to: (i) the class of migraine patients, (ii) the individual patient, and (iii) the previous dialogue. Preliminary evaluation of the system indicates that patients find it useful and informative. More extensive evaluation is in progress.

Computer-Assisted Instruction↗

Using the UMLS Semantic Network as a basis for constructing a terminological knowledge base: a preliminary report.

Sharing and reuse of knowledge bases is recognized in Artificial Intelligence and Medical Informatics as beneficial, but difficult. Reusing an existing knowledge base can save considerable time and effort during the knowledge engineering phase, and facilitates integration of systems. However, the degree to which knowledge can be shared among different applications is still mainly an empirical question. In this paper, we describe the preliminary results of our attempt to reuse the UMLS Semantic Network as an ontology for the knowledge base of a patient education system.

Algorithms↗

[Trans-1-(4-phenylcyclohexyl)ethylamine derivatives with antidepressant activity. II].

Some derivatives of trans-1-(4-phenylcyclohexyl)ethylamine (A) with a substituent at position 4 of the phenyl group were prepared and tested for antireserpine activity on the CNS. All compounds showed reduced activity compared with that of (A) except the amino derivative (II) which proved more active but at the same time showed increased toxicity and other adverse effects on the CNS.

5-Hydroxytryptophan↗

[Methionine derivatives with liver protecting activity].

Some methionine derivatives with the amine group acylated with an aliphatic group bearing a free, esterified or etherified thiol group in the omega position were prepared and tested for protection against CCl4, paracetamol, ethyl alcohol and ethionine intoxication. Acid (XIV) (MG 28013) (Table I) and some of its alkyl derivatives (XVIII) (MG 28228) and (XIX) (MG 28226) proved to have significant activity in these tests. A more in-depth study on MG 28226 however indicated a slight intolerance when subacute toxicity was examined (90 gg).

Acetaminophen↗

[Synthesis and pharmacologic study of new esters of naproxen with derivatives of N-oxyethylpiperazine].

The preparation of naproxen esters with N,N'-dioxyethylpiperazine and derivatives of N-oxyethylpiperazine with various substituents on the nitrogen is described. Study of analgesic-antiinflammatory properties in comparison with a reference compounds has shown that in most of the new compounds analgesic activity (phenylquinone) is preserved whereas antiinflammatory activity (carrageenin) is generally reduced. The diester with N,N'-dioxyethylpiperazine (MG 28136) proved most interesting, showing clear pharmacological activity and very low toxicity.

Animals↗

[N-acylated derivatives of cyclohexylaniline with potential antiallergic and analgesic-antiinflammatory activity].

Some N-acylated derivatives of cyclohexylaniline were prepared. These can be considered as derived from oxarbazol (A), a carbazolic structure with antiallergic activity, by breaking the bond between carbon atom 4a and 4b. In the new molecule the following groups were introduced: benzoic acid, salicylic acid, acetylsalicylic acid and tetrazol. The synthesized compounds were studied for analgesic, antiedema and antiallergic activity. Some showed analgesic action (phenylquinone) comparable with that of naproxen. Antiinflammatory activity was slight and antiallergic activity nonexistent.

Aniline Compounds↗

Nutritional studies on anti alpha-amylase: I) Influence on the growth rate, blood picture and biochemistry and histological parameters in rats.

Anti-alpha-amylase is a protein characterized by an antienzymatic activity in the sense that it prevents hydrolysis of the alpha--1,4 glycoside bond of starch. Such action could be exploited for reducing the caloric value of the diet. We studied the in-vivo effectiveness of large doses of anti-alpha-amylase extracted from white beans (Phaseolus vulgaris). The growth rate of rats was clearly impaired, the blood pictures and biochemistry showed modifications, and the internal organ histology revealed alterations in the liver and kidney.

Animals↗

Nutritional studies on anti-alpha-amylase: II) Lipid metabolism investigation: fatty acid composition of organs and tissues.

The effect of dietary anti-alpha-amylase on some aspects of lipid metabolism has been studied after having shown that rats fed proteins from legumes containing anti-alpha-amylase (to cover one-third of the protein quota in the diet) failed to absorb carbohydrates contained in starch to the point that the total caloric intake was sharply reduced and their growth stunted. Upon feeding rats anti-alpha-amylase, destruction of fatty deposits was observed. The animals, on the other hand, did not show evidence of important structural pathology.

Animals↗

Nutritional studies on Spirulina maxima.

This study was designed to explore the nutritional value of proteins derived from algal biomasses of genus Spirulina maxima, with a view to the possible use of such proteins in human alimentation. Recently the use of such biomasses has commanded attention both as an alternative source of alimentary protein and as a coadjuvant in diet treatment requiring a reduced caloric intake - this because these substances seem to prolong gastric transit time and so produce a feeling of satiety. Our research was conducted in young growing rats; it provided confirmation of the validity of Spirulina as a protein source in terms of good weight gains by the test animals and freedom from adverse effects; the same research, on the other hand, failed to confirm the effectiveness of these protein materials in reducing caloric intake: throughout the test period, indeed, feed consumption (hence caloric intake) was practically the same in the control lot and in animals receiving Spirulina protein.

Animals↗

Nutritional studies on maltitol. Part 2: Effect on lipid metabolism and fatty acid composition of different rat tissues.

This study has been designed to investigate the possible metabolic consequences of maltitol feeding (replacing 1/3 of the dietary carbohydrates) on the fatty acid composition in various body compartments of the rat. The detailed biochemical analysis of the lipid composition rules out the possible interference of this disaccharide on the lipid metabolism, at least with the dosage and duration of treatment used in the experiment.

Adipose Tissue↗

Nutritional studies on maltitol. Part 1: Acceptability, energetic yield, effects on growth and blood biochemical parameters.

Maltitol is a disaccharide molecule with special physico-chemical characteristics due to a glycosidic bond which is not easily split by the natural disaccharidases. The present study was designed to evaluate the effects of a prolonged feeding with maltitol on growing rats. Acceptability, caloric yield, intestinal absorption and metabolic effects have been determined.

Animals↗

[Heterocyclic compounds with potential anti-inflammatory activity containing a 4-aminophenylalkanoic acid residue. V. Derivatives of 2,4-dihydro-3H-pyrazole-3-one].

The synthesis and pharmacological study of some derivatives of 2,4-dihydro-3H-pyrazol-3-one of general formula (I) are described. The compound in which R = C6H5 and R' = CH3 [2-(4- carboxymethylphenyl )-4-phenyl-5-methyl-2,4- dihydropyrazol -3-one] (MG 18949) proved to have antipyretic activity equal to that of ibuprofen and aminopyrine.

Analgesics↗

[Derivatives of 4-phenylcyclohexylethylamine with antidepressive activity].

Several new derivatives of trans-1-(4-phenylcyclohexyl)-ethylamine (M.G. 6669) have been synthesized with various substituents at the alpha-carbon and/or at the amine nitrogen atom. All compounds were evaluated for a potential antidepressant activity taking M.G. 6669 as reference. They turned out to be less active than the reference substance. Pharmacological evaluation of M.G. 6669 itself was broadened during this work. The good antidepressant properties of this compound were confirmed, accompanied however by some toxic phenomena.

Aggression↗

[Heterocyclic compounds containing a 4-aminophenylalkanoic acid group with potential antiinflammatory activity. II. 2-Substituted morpholine derivatives].

Derivatives of 4-aminophenylalkanoic acids where the amino groups is part of a 3-morpholinone or a 2-morpholine ring, substituted in position 2 with a methyl, phenyl, 2-thienyl or (2-cyclohexyl)phenoxymethyl residue are described. Pharmacological evaluation aimed at evidencing analgesic and anti-inflammatory activity gave no noteworthy results.

Animals↗

[Heterocyclic compounds containing the residue of a 4-aminophenylalkanoic acid with potential anti-inflammatory activity. IV. Derivatives of 2-phenyl-2H-indazole].

Numerous derivatives of 2-phenyl-2H-indazole were prepared. The compounds were of general formula I: where R is an acid, neutral or basic radical and R1, R2, R3 represent various functional groups, hydrogen atom or chlorine. The compounds were examined for analgesic-antiinflammatory properties and in some cases as inhibitors of platelets aggregation. Among the compounds where R is an alkanoic acid residue, the only compound showing interesting activity was M.G. 18755 [R = CH(CH3) COOH; R1, R2, R3 = H] and its lysine salt (M.G. 18334), which in various tests showed activity greater than that of ibuprofen. The homologous butyric derivative (M.G. 18860) showed a good anti-aggregatin activity.

Animals↗

[2-(2-Thienyl)morpholines with CNS activity].

The synthesis and pharmacological investigation of 2-(2-thienyl)morpholine and some of its derivatives substituted on the nitrogen are described. The non-substituted compound showed interesting antidepressive properties with a pharmacological profile similar to that of imipramine.

5-Hydroxytryptophan↗