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Biomedical subjects

G Carlin

Publications and source records attributed to G Carlin.

At least 37 records · Page 2Linked to original sources
PubMed1985

Peroxidation of liposomes promoted by human polymorphonuclear leucocytes.

Human polymorphonuclear leucocytes were found to promote peroxidation of phospholipid liposomes upon stimulation by phorbol myristate acetate. Peroxidation required the presence of either pyrophosphate-chelated or ADP-chelated iron, whereas iron chelated to EDTA or ATP had no effect. Peroxidation was also catalyzed by ferritin, but not by transferrin. Superoxide dismutase abolished the peroxidation, whereas catalase and apparently also the hydroxyl radical scavenger dimethyl sulphoxide were inactive, indicating that the peroxidation was mediated by superoxide radicals but not by hydrogen peroxide or hydroxyl radicals. Xanthine oxidase-promoted peroxidation was studied for comparison and showed similar characteristics except that transferrin catalyzed the peroxidation. Peroxidation of membrane lipids may be a mechanism whereby granulocytes cause tissue damage in inflammation. The drugs paracetamol, gentisic acid and 5-aminosalicylic acid inhibited lipid peroxidation, probably through their ability to react with the superoxide anion.

Cytochrome c Group↗
PubMed1982

Fibrinolysis inhibition after a major standardized trauma.

The present investigation on 20 patients after total hip replacement surgery has confirmed that the posttraumatic increase of the fibrinolysis inhibition activity (FIA) in serum and plasminogen-depleted serum is due to the primary fibrinolysis inhibitor (PFI, alpha 2-antiplasmin). This protein exists in at least two forms and it was indicated that PFI alpha with affinity to immobilized plasminogen, is mainly responsible for the posttraumatic variations of the FIA in plasminogen-depleted serum. PFI beta, the major part of the PFI-related antigen, which has none or low such affinity, displayed weak FIA and relatively small increase after the surgical trauma. It was established that the posttraumatic increase of the FIA was not derived from the low molecular weight fraction in serum of those patients.

Aged↗
PubMed1981

Delayed elimination of fibrin from the lungs in rats given alpha 2-antiplasmin.

Injection of human alpha 2-antiplasmin resulted in delayed elimination of fibrin from the lungs in rats with thrombin-induced intravascular coagulation. The amount of alpha 2-antiplasmin injected was chosen so as to simulate the posttraumatic increase of this inhibitor in man. By injecting trace amounts only of radiolabelled alpha 2- antiplasmin a specific uptake of this protein in the lungs was noted after the thrombin-induced coagulation. The results may indicate that the posttraumatic increase in alpha 2-antiplasmin is of significance for the delayed elimination of fibrin seen in patients following trauma.

Animals↗
PubMed1980

Effect of dextran on fibrinolysis inhibition activity in the blood after major surgery.

Patients undergoing total hip replacement surgery were given 500 ml of 6% dextran 70 or 5% albumin by intravenous infusion on the third postoperative day when the post-traumatic fibrinolysis inhibition has reached its maximum. The large increase in the fibrinolysis inhibition activity measured by a clot-lysis system was counteracted by the infusion of dextran, whereas the albumin infusion had no such effect. The plasma concentration of antiplasmin (chromogenic substrate assay) and the immunologically determined plasma levels of the primary fibrinolysis inhibitor (alpha2-antiplasmin), alpha2-macroglobulin, alpha2-antitrypsin and plasminogen were not changed after the infusion of dextran. It is hypothesized that dextran exerts its effects partly by interfering with the interaction between the primary fibrinolysis inhibitor, fibrin and plasmin(ogen) and by enhancing the activation rate of plasminogen. This observed effect of dextran may be of importance in the prevention of deep venous thrombosis and pulmonary embolic complications, as well as pulmonary microembolism.

Aged↗
PubMed1980

Urokinase-induced fibrin clot lysis and its inhibition by plasma.

The kinetics of the urokinase-induced plasmin digestion of fibrin clots has been studied. Some theoretical aspects on the kinetics of the underlying enzyme reactions are presented. It is shown that the clot-lysis time may be used to measure the relative amounts of fibrinolysis inhibitors in plasma.

Antifibrinolytic Agents↗
PubMed1979

Severity and prognosis after early excisions from one to twenty percent of the body surface area.

The authors review 101 small and medium early excisions with immediate grafting. They study several parameters concerning the severity of the burn, the time and the duration of the surgical procedure, the blood losses, the effect on the protidemia during the shock period, the duration of the hospital care, the septicemic risk, the mortality, and the functional and cosmetic results. They come to the conclusion that, under 15% of the body surface area, early excision can be done at one single operation with hardly any risk, and that it is better to perform it as soon as possible (before 12 hours if possible). With a good splinting and a daily rehabilitation, the cosmetic and functional results are very satisfactory.

Blood Volume↗
PubMed1979

Effect of infusion of dextran 70 on fibrinolysis inhibition activity in human serum.

The effect of dextran on fibrinolysis inhibition activity was studied in the serum of normal (uninjured) persons and of post-traumatic patients. An intravenous infusion of 500 ml dextran 70 significantly decreased the fibrinolysis inhibition activity in the serum in both groups. The decrease was greater in the trauma group. Treatment with dextran in the post-traumatic phase may therefore diminish the risk of development of complication due to thromboembolism.

Adolescent↗