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Biomedical subjects

G Carrera

Publications and source records attributed to G Carrera.

At least 73 records · Page 4Linked to original sources
PubMed1979

Studies of absorption, distribution and excretion of 2,6-xylidide of 2-pyridone-3-carboxylic acid (isonixine).

The absorption, tissue distribution and excretion of 14C-labelled 2,6-xylidide of 2-pyridone-3-carboxylic acid (isonixine) have been investigated in the rat after intragastric and intraduodenal administration. Isonixine was rapidly absorbed from the gastro-intestinal tract. The half-life of absorption was 3.15 h. The product was soon distributed in the whole organism. The radioactive metabolites were excreted rapidly, the major route being the urinary tract (85% in 72 h). There was no evidence of long-term storage of isonixine in the body. These results were confirmed by autoradiographic studies in the mouse after oral administration.

Anilides↗
PubMed1977

Tannic acid and oxidized tannic acid on the functional state of rat intestinal epithelium.

Diets containing tannic acid at the level of 3% of dry matter were fed to rats in order to ascertain the origin of fecal nitrogen and the effect of tannic acid on the intestinal mucosa. At the same time in order to explain the effect of oxidation of tannins, we administered diets containing oxidized tannic acid or tannic acid associated with an antioxidizer (sodium sulfite) at the level of 1% of dry matter. The increased excretion of sialic acid and glucosamine during ingestion of tannic acid indicated that the excess of fecal nitrogen mainly corresponds to the mucus hypersecretion observed by histology. Fecal analysis revealed perturbations in movements of water and ions. The study of the metabolic activity of isolated enterocytes and the activity of some enzymes in a homogenate of these cells showed an inhibition of oxygen consumption and succinic dehydrogenase activity. Addition of reducing agent (sodium sulfite) to the diet had little effect on the action of tannic acid; but previous oxidation of the tannin reduced the effects observed, particularly in the case of fecal nitrogen loss.

Animals↗
PubMed1976

[Nutritional effects in the rat of oxythioquinox (morestan) as a function of its concentration and of the lipid content of the diet].

Of two groups of rats, one received a normal diet and the other a high fat diet for 5 weeks. The effects of oxythioquinox, administred at diet concentration of 200, 400 and 800 mg/kg, of fresh food are studied on weight gain, food and calorie intake and on the weight and composition of various organs. Growth, food and calorie intake are diminished in relation to oxythioquinox concentration in the diet. There exist an interaction between the fat content of the diet and the toxicity of oxythioquinox. The decrease of the efficiency of calorie by oxythioquinox indicates a perturbation of the rats metabolism. An increase in the weight of the liver is observed with a significant interaction between the fat concentration and the oxythioquinox with the results expressed in weight of organ per 100 g body weight. There is an increase in the degree of the water content of the animals liver with normal fat diet. In the case of a high fat diet there is an increase of cholesterol and fatty acid content. In all case, the variations are more strongly marked in relation to the oxythioquinox concentration of the diet and at the same concentration, the high fat diet is more effective that the normal diet. There is an interaction between the lipids in the diet and the oxythioquinox and this interaction indicates, an accentuation of the effects of oxythioquinox by lipids of the diet.

Animals↗
PubMedDate not supplied

Mast cells in the testis, epididymis and accessory glands of the rat: effects of neonatal steroid treatment.

Mast cells in the testis of control adult rats were found almost exclusively around subcapsular blood vessels. Discrete mast cells were distributed throughout the stroma of the epididymis and sex accessory glands. In neonatally estrogen-treated rats, a greater number of mast cells was present in the testicular interstitium, whereas no significant increase in the number of mast cells per square millimeter of stroma was found for the epididymis and sex accessory glands, despite stromal proliferation. On the other hand, androgen-treated rats did not have increased mast cell numbers in any organ. These results indicate that the increase in mast cell numbers was estrogen-dependent, specifically related to the testis and did not seem to be a consequence of the increase in the connective interstitial tissue.

Animals↗
PubMedDate not supplied

[Toxicokinetics of a thioquinoxaline component: the oxythioquinox (author's transl)].

The absorption and distribution of Morestan 35S in the organism of the rat were studied after administration by stomach tube. It was shown that Morestan, in vivo and in vitro, forms a complex with plasma proteins and particularly with albumins. Most of the plasma Morestan is distributed like this. After intravenous admininstration, the constant of elimination, K13, and the biological half-life determination show that plasma Morestan 35S is eliminated very slowly. The K12 and K21 constants indicate that there is an equilibrium between the plasma compartment and a peripheral compartment. After intragastric administration, the increase of radioactivity in epididymal adipose tissue, indicate that the peripheral compartment should include the adipose tissue.

Administration, Oral↗
PubMedDate not supplied

Oxythioquinox-induced hepatomegaly.

Oxythioquinox, administered in solution in the dietary lipids at 400 mg/kg fresh food for 21 days, caused liver hypertrophy with severe steatosis. The levels of liver triglycerides increased 40-fold, phospholipids 2-fold and cholesterol 7-fold respectively. The steatosis was thought to be due to the effect of oxythioquinox on cell energy metabolism. The results demonstrate the variation of oxythioquinox toxicity with its degree of solubilisation in the vehicle of administration.

Animals↗
PubMedDate not supplied

[Toxicity of oxythioquinox (Morestan) administered in a lipid solution].

Administered to rats by stomach tubing oxythioquinox (Morestan) toxicity is very strongly increased after solubilisation in olive oil. The oxythioquinox DL50, in this case, is 500 mg/kg although we can reach 2.8 g/kg in aqueous suspensions. When it is administered (1 g/kg) in aqueous suspension, the decrease in body weight is the same as these observed with a 5 fold lower dose in oil. Conversion rate feed and weight of differents organs decrease when animals are daily submitted to oxythioquinox in oil, during 16 days, compared with animals treated with an equivalent dose in aqueous suspension. Potentiation, in oil solutions, of the decrease of oxythioquinox intestinal transit, promoting its absorption, could explain the increase of oxythioquinox toxicity in oil solution.

Administration, Oral↗