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G Cascio

Publications and source records attributed to G Cascio.

72 records · Page 4Linked to original sources
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[Physiopathology and clinical aspects of monoclonal IgM gammopathy].

Ten subjects with IgM monoclonal gammopathy were studied with particular references to their clinical pictures. In 7 cases, the M component was W's macroglobulinaemia (MW) and in 3 undetermined monoclonal gammopathy (UMG). Serum IgM was always greater than 2170 mg% in MW and greater than 1120 mg% in UMG. All patients were over 45. Haemorrhage and autoimmune phenomena were noted in 2/10 cases, and liver and spleen enlargement in 7/10, peripheral lymphocytosis in 5/10, marrow lymphoplasmacytosis in 7/10, and plasma hyperviscosity in 7/10. Beta-2-microglobulin (beta-2MG) was higher on average in the 7MW cases than in the 3 UMG. A monoclonal peak was observed casually in 2/10 and after it had been clinically suspected in 3/10. ESR was high in all cases. The clinical and laboratory data are interpreted in the light of the possible pathogenetic mechanism. In addition, stress is laid on their importance in the differentiation of these two forms of IgM monoclonal gammopathy.

Aged↗
PubMedDate not supplied

Humoral immunological parameters in Italian patients with oral lichen planus.

Serum humoral immunological parameters were determined in 25 patients with atrophic-erosive forms of oral lichen planus (OLP) (Group 1), in 28 patients with reticular-plaque-like lesions of OLP (Group 2) and in 21 healthy patients without oral lesions (Group 3). Comparing patients affected by atrophic-erosive forms of OLP (Group 1) with normal controls (Group 3), increased levels of serum IgG approaching the statistical significance were found (Kruskal-Wallis test p = 0.0572). It was also found a significantly higher value of kappa (Kruskal-Wallis test p = 0.0017; Mann-Whitney test with Bonferroni's correction p < 0.001) and lambda (Kruskal-Wallis test p = 0.0346; Mann-Whitney test with Bonferroni's correction p = 0.013) light chains in patients with atrophic-erosive OLP (Group 1) as compared with normal controls (Group 3). However these higher levels were probably caused by strong prevalence of chronic liver diseases (40%), in patients with atrophic-erosive variety of OLP. No one of these patients was affected by autoimmune liver disease. No differences were noted between atrophic-erosive OLP (Group 1) and hyperkeratotic OLP (Group 2). This study does not confirm the suggestion that patients with OLP may have a generalized immunologic disorder and it also add some evidences that the role of humoral immunity in the pathogenesis of OLP is probably secondary to the cell-mediated reaction against basal keratinocytes.

Adult↗
PubMedDate not supplied

Phenotypic analysis of peripheral blood cell immunity in Italian patients with different varieties of oral lichen planus.

Quantitative analysis of peripheral blood lymphocytes was carried out in 25 patients with atrophic-erosive type of oral lichen planus (OLP) (Group 1), in 28 patients with reticular-plaque like lesions of OLP (Group 2) and in 21 healthy patients (Group 3) by using flow cytometry. CD4+ subsets decreased significantly in patients with reticular-plaque like varieties when compared with healthy patients (Group 3) (One way analysis of variance p = 0.039; t-test with Bonferroni correction p < 0.05). Moreover, in patients with hyperkeratosic forms of OLP (Group 2) CD8+ cell populations were significantly higher than in controls (Group 3) (Kruskal-Wallis test p = 0.035; Mann-Whitney test with Bonferroni's correction p < 0.0001) and consequently CD4/CD8 ratio was significantly lower in patients with reticular-plaque like lesions than in controls (Kruskal-Wallis test p = 0.01; Mann-Whitney test with Bonferroni's correction p = 0.013). No statistical differences between patients of Group 1 (atrophic-erosive OLP) and the other two Groups (hyperkeratosic OLP and healthy controls) were detected. 40% of the patients of Group 1 were affected by chronic hepatopathies, most of which were related to hepatitis C virus (HCV), but the data were not substantially modified after adjustment for the patients with chronic liver disease HCV positive. There is no clear evidence that these results indicate the existence of a different pathogenetic mechanism between erosive-atrophic and hyperkeratosic types of OLP. On the other hand, these results and the previously reported immunohistochemical findings suggest that quantitative alterations of peripheral blood lymphocytes in hyperkeratosic varieties of OLP could represent a shift of CD4+ cells from the vascular to the oral mucosa compartment.

Adult↗