Biomedical subjects
Publications and source records attributed to G Catár.
Cultivation of necroptic material taken by pathologist or obstetrician according to determined indicative groups was performed during the years 1986-1990. Cytogenetical evaluation was feasible in 157 cultivated samples from the total of 252. There were found 32 pathological karyotypes among them.
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Toxoplasma gondii is known to have an affinity to lymphatic tissue. A series of 506 children with chronic tonsillitis were examined serologically for toxoplasmosis by means of CBR, IIR and ELISA. In 7.7% of the children examined low toxoplasma antibody titers were recorded. Isolation experiments performed on tonsillar tissue of the children with the highest toxoplasma antibody titers were negative. Direct microscopic evidence of tissue toxoplasma cysts failed to be established and the cytopathologic picture characteristic of nodal toxoplasmosis was not present in smears of cells aspirated from lymphatic nodes regional to palatine tonsils. The authors assumed that chronic toxoplasma tonsillitis did not occur in the series studied. In our ecological conditions, T. gondii may not be involved in the etiology of chronic tonsillitis, or it may participate to an extent which is epidemiologically negligible. (Tab. 4, Ref. 14).
The oral protozoa Entamoeba gingivalis and Trichomonas tenax do not occur in small children and are rarely found in older ones. In adolescents their occurrence rate keeps increasing with age. They parasitize in an oral cavity changed by inflammation, yet also in a healthy mouth. Their highest occurrence rate has been recorded in adults with periodontosis and atrophy of the periodontium, a somewhat lower one in adults with gingivitis. The authors addressed the question whether the presumed low occurrence rate of oral protozoa in children becomes increased in drug-induced gingivitis after treatment with the antiepileptic 5,5-diphenylhydantoin. Cultivation for oral protozoa was performed in 231 children and adolescents. Of these 59 were epileptics. Drug-induced gingivitis was present in 66% of the epileptics. Drug-induced gingivitis did not increase the occurrence rate of oral protozoa as compared to the findings in the rest of the series studied. (Tab. 9, Ref. 7.).
Toxoplasma gondii is know to have an affinity to lymphatic tissue. The authors studied whether after infection of the child's body T. gondii does or does not determine the chronic course of tonsillitis. In 712 children with chronic tonsillitis serological examinations for toxoplasmosis were carried out by means of RVK, NIR and ELISA. Low titers of toxoplasme antibodies were found in 8.0% of the children examined. In light of the following findings the authors conclude that toxoplasme tonsillitis did not occur in their series: toxoplasma antibodies failed to be increased; their titers in seropositive children were low; toxoplasma was not isolated from tonsillar tissue; no direct microscopic evidence of the parasite could be established in smears of cell aspirate from lymph nodes regional to the palatine tonsils; the same smears failed to present the cytopathologic picture characteristic of nodal toxoplasmosis. In our ecologic conditions T. gondii is presumably not involved in the etiology of chronic tonsillitis, or it may be involved but to an epidemiologically not appreciable extent. (Tab. 10, Ref. 18).
Specimens obtained from 176 eight- to nineteen-year-old subjects were cultured for oral protozoa. Of the given series, 25 subjects (14.2%) had in their mouth only E. gingivalis, 5 (2.9%) had a mixed invasion of E. gingivalis and T. tenax, and 2 subjects (1.1%) had only T. tenax. A total of 32 subjects (18.2%) were infested by oral protozoa. The following conclusions were made: oral protozoa occur also in children and teenagers with a cured or intact dentition; their occurrence rate was higher in 11- to 19-year-old subjects than in the lower age groups; both protozoa can occur simultaneously; their occurrence rate was age dependent (increasing with age) with the rate of E. gingivalis rising significantly more rapidly with age than that of T. tenax; their occurrence was found to be sex dependent with higher rates in boys than in girls. In the light of the high recovery rate (83.3%) of E. gingivalis from dental and periodontal swabs, not only specimens of saliva should be collected but also dental nad periodontal swabs should be taken and cultured when studying the occurrence of oral protozoa in the population. (Tab.4,Fig.2,Ref.7).
The authors analyze a group of pregnant women examined at the Chair of Biology and Parasitology of the Medical Faculty J. A. Komensky's University between 1981 and the end of August 1989. During this period they cultivated cells from 1755 specimens of amniotic fluid. In the article they evaluate the detection rate of pathological conditions during this period.
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Over the years 1986-1988 necroptic material, collected according to 5 established indication groups, was cultured. A total of 202 samples of necroptic material cultured and 122 of these samples were analyzed cytogenetically. Seventeen pathologic karyotypes were diagnosed in the material, namely 7 cases of Down's syndrome, 2 cases of Klinefelter's syndrome, 2 cases of D/D translocation, 1 case of Turner's syndrome, 1 case of gonosomal mosaicism, and 1 case of Patau's syndrome.
The authors analyze ethico-philosophical and socio-legal problems of patients with AIDS in their relation to people they are in frequent contact with, i.e. family, relatives, sexual partners, as well as medical and paramedical staff. They deal with the problem of compulsory notification of the disease on the one hand, and of secrecy compelling for health care workers on the other hand. The potential penojudicial responsibility of subjects infected with AIDS in spreading the infection is being considered, as well as the problem of enforced diagnotic examination and hospitalization. The obligation of the doctor to provide therapeutic and preventive care to each citizen, and thus also to patients with AIDS, is being emphasized.
Over the years 1984-1987, 829 children from the Slovak Socialist Republic, aged from 0 to 15 years, with suspect toxoplasmosis were examined for the presence of toxoplasma antibodies by the serodiagnostic methods RVK, NIR, and ELISA. The percentage of toxoplasma antibodies yielded by the individual methods was as follows: RVK--39.5%; NIR--74.4%; ELISA-IgG--67.7%; ELISA-IgM--60.4%. Based on these results the authors conclude that the child population up to the age of 15 years is an at risk group with an increased possibility of contracting toxoplasmosis by frequent contact with the soil, sand, water, and animals, as well as by consuming not adequately cleaned fruit and vegetables. To protect the child population from toxoplasmosis greater attention is to be given to hygienic, nutritional and serodiagnostic prevention.
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