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Biomedical subjects

G Celle

Publications and source records attributed to G Celle.

18 recordsLinked to original sources
PubMed1992

Duration of acid suppression in H2-antagonist nonresponders.

We monitored 24-hour gastric acidity in 16 resistant duodenal ulcer patients treated with ranitidine 300 mg hora somni (9 cases) and famotidine 40 mg hora somni (7 cases) for 3 months. Data obtained in these patients were compared with those of a group of unselected duodenal ulcer patients who responded to a 4-week course of the same H2-antagonist regimens. In the time window 22.00-07.59 h there was a reduced effectiveness of ranitidine in nonresponder patients in terms of both mean pH levels (4.8 +/- 0.9 vs. 5.6 +/- 0.7, p < 0.04) and the mean duration of the antisecretory effect defined as the time spent in minutes above pH 3.0 (403 +/- 73 vs. 490 +/- 59, p < 0.02). Also, the action of famotidine was diminished in nonresponder patients in the same time interval as regards both pH values (4.1 +/- 1.6 vs. 5.7 +/- 0.6, p < 0.03) and the duration in minutes (329 +/- 163 vs. 473 +/- 45, p < 0.05). The analysis of all individual nonresponder patients shows that there was a certain variability in the duration of acid suppression: the majority of them had an adequate nocturnal acid inhibition, while in some cases of both the ranitidine and the famotidine subgroups, acid inhibition lasted only few hours or did not occur at all. At present, it is not possible to distinguish with certainty two different subsets of H2-antagonist nonresponders because of the small size of the population studied.(ABSTRACT TRUNCATED AT 250 WORDS)

Drug Tolerance↗
PubMed1979

[Persistent chronic hepatitis. Anatomical and functional study].

A functional study was made of 40 patients with bioptically diagnosed CPH. Fractional BSF clearance was the most frequently altered test and its correlation with the anatomical damage was significant. In particular, the fractional uptake clearance (K1) gave a pointer to both the presence of liver damage and its type. Elimination clearance (K2) may also be useful, especially in the differentiation of histological pictures on the borderline between CAH and CPH. In the evaluation of CPH, therefore, BSF clearance is of marked assistance both in rounding out the histological diagnosis, and in cutting down the need for control biopsies.

Adult↗
PubMed1977

Toxic and immunodepressive effects of L-asparaginase from E. coli and from Erwinia carotovora following chronic administration in rats.

The effects of the administration of L-asparaginase from E. coli and Erwinia carotovora were studied in rats treated for 90 days with 800 or 3200 IU/kg body weight. The studies included overall toxicity on the liver, pancreas, and enteric mucosa as evaluated by both opitcal and electron microscopic examination, biochemical findings, behaviour of IgM-hemolysin producing cells, and antias-paraginase antibody production. The toxic effect and the immunodepressive activity appeared rather early, tending later to decrease. No sex correlation or clear cut dose correlation were observed. However, slight differences in toxicity between the two types of L-ASN-ase were present.

Animals↗
PubMedDate not supplied

[Experimental study of the relationships between activation of erythropoiesis and hematotoxicity of some antitumoral agents (author's transl)].

The changes in the blood toxicity of some antitumoral chemotherapeutic agents in the presence of erythropoiesis activation by bleeding are evaluated. The general toxicity seems to be unaffected but the damage to erythropoiesis proved, in absolute terms, to be more severe in the bled animals. The recovery of hematopoiesis was slower after some drug than others. These results are discussed in the light of present knowledge of hematopoietic kinetics and of the relationships between antiblastic drugs and staminal hematopoietic compartments.

Animals↗
PubMedDate not supplied

Chronic treatment with azathioprine and cyclophosphamide in rats: structural and functional effects on small intestine and liver.

A report is presented of the effects upon the liver and enteric mucosa of rats treated chronically with azathioprine (AZA) and cyclophosphamide (CY) in equiactive doses three times greater. The groups treated either with equiactive doses of AZA and CY or with doses three times greater of AZA and CY presented limited and moderate morphological alteration in the liver and in the mucosa of the small intestine, while all rats treated with high dose of CY died in the first phase of the experiment.

Animals↗