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G Cerone

Publications and source records attributed to G Cerone.

30 records · Page 2Linked to original sources
PubMedDate not supplied

Poly-hormonal evaluationof pulsatile adenohypophysis incretory activity during sleep in normal, experimental and pathologic conditions.

Secretory patterns of some anterior pituitary hormones were recorded during sleep, and related to EEG-phases. The same observations were carried out in conditions in which the normal sleep course was intentionall (i.e., repeated arousals, administration of tryptophan) or pathologically (i.e. chronic schizophrenia) modified. Plasma gonadotropins (lh, fsh), growth hormone and ACTH were assayed. In basal conditions, the well-known peak of HGH, which corresponds to the delta phase of sleep, was confirmed. This peak is strictly linked to the number and duration of stage 4 sleep, and follows it in its experimental and/or pathological disturbances. The secretion of ACTH, on the other hand, seems to be completely independent from the morphology of sleep. The secretion of this hormone is typically phasic; along with this phasic secretion, a background secretion is detectable, which increases steadily during the sleep span, with maximal values in the early morning hours. Gonadotropin secretion is pulsatile, episodic and completely independent from the sleep phases, in basal as well as in experimental and pathologic conditions.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

Parkinsonian tremor: a neuropharmacological study.

In the Parkinsonian syndrome tremor is the symptom which still eludes pharmacological therapy. The authors report the results of nine cases of Parkinsonian tremor in which agonist and antagonist drugs acting on the receptors were employed. These were dopaminergics, acetylcholinergics, serotoninergics, histaminics, and alpha- and beta-adrenergics. The data obtained demonstrate the involvement of all the neurotransmitters studied, some directly through quantitative modifications, others indirectly through their involvement in reciprocal functional equilibria. A sytem of equilibria is hypothesized in which the histamine: serotonin ratio is given greater emphasis. (Acta neurol belg., 1977, 77, 213-229).

Acetylcholine↗
PubMedDate not supplied

[Radiculopathy and the organization of health services: applicability verification of a technic for analyzing time factors in diagnostic procedures].

The PERT is a SPR (Reticular Programation System) based on statistic-mathematic models. Since some years they are applied to productive processes to increase the efficiency and effectiveness. They all have a same base structure which is the net that is composed by the logical succession of the event and the activity which has the part of the project. Determining the minimum time (to), the maximum one (tp) and the more frequent time (tm) of each activity and applying the statistic method PERT, one gets the probable duration (te) of every activity and the critical path of the net is placed in evidence. This is formed by the chain of those activities whose duration determines the total duration of the project. The Authors have desired to verify the applicability of SPR even to the "medical industry" and, more precisely, to the diagnostic process for the verification of radiculoneuropathy. Such pathology affects a large part of the active population. The diagnostic process in this case comprises besides an accurate neurological and clinical examination of the patient, also the x-ray exam, the electromyography, the Computed Tomography (CT) and the Magnetic Resonance Imaging (MR) exam. These last two investigations gives an increase of diagnostic accuracy. With the collaboration of the physicians of the diagnostic Service, the Authors have measured in every step of the diagnostic procedure the waiting time of 48 patients with low back pain. Applying the PERT method, it has been possible to put in evidence in the net the critical activities. They are such that their duration time determines the probable duration of the whole diagnostic process. Such duration in this case it corresponds to 91 days with a standard deviation of 33 days. The delay of any critical activity causes a lealy of the whole route. This delay influences negatively on the patient's health. Besides it determines an economic damage to the system because a relation cost/time exists. The systems of reticular programmation have as objective not only the one of improving the programmation and the control of the processes, but also the attainment of an optimum cost/time ratio, varying in a way that the total cost of the realization of the process is minimum. They represent a useful criterion to direct Quality Assurance (Q.A) in the local political sanitary context, within the bounds of organization of technical - scientific quality. An accurate application of the Q.A. should modify besides the duration of the critical activities.

Adult↗
PubMedDate not supplied

[Computerized axial tomography and electromyography in vertebral and spinal cord pathology].

Fifty patients with lumbar spinal disease, 47 of them with disk herniation, were studied preoperatively using both electromyography and computerized tomography (CT), in order to verify the mutual diagnostic significance and accuracy of these techniques. Electromyographic studies provided correct informations regarding the level of the lesion in 41 patients with 1 mistaken level and 8 false negatives, without indicating the nature of involved pathologies. The specific nature of the lesions was correctly indicated by CT studies in 43 patients with 4 incorrect diagnoses and 3 false negatives, without defining the functional loss produced by the lesions. Using electromyography and CT together, first electromyographic studies to establish the spinal level to investigate principally with CT, the diagnostic accuracy can improve because of the decrease of the false negatives.

Adult↗
PubMedDate not supplied

The 24-h pattern of human prolactin and growth hormone in healthy elderly subjects.

Determination of plasma prolactin concentration every 2 h in twelve healthy elderly subjects, aged between 62 and 78, indicates that the secretory rhythm is not modified with age and that it remains synchronized with the sleep-wake cycle. The increase of awake time during the night in old age does not change substantially the rise of nocturnal prolactin levels. The 24-h profile of growth hormone is characterized by a frequent decrease or absence of sleep-related peaks in elderly subjects. This reduction of growth hormone nocturnal secretion does not seem secondary to an alteration in sleep structure.

Aged↗